1. Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters.

    PNAS 112(8):2343 (2015) PMID 25675492 PMCID PMC4345556

    Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-...
  2. Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters.

    PNAS 112(8):2343 (2015) PMID 25675492 PMCID PMC4345556

    Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-...
  3. Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice.

    American Journal of Physiology - Gastrointestin... 306(5):G445 (2014) PMID 24407593 PMCID PMC3949022

    Intestinal intussusception (ISS) commonly causes intestinal obstruction in children. One mechanism that has been proposed to cause ISS is inflammation-induced alteration of intestinal motility. We investigated whether innate inflammatory factors or altered motility is required for induction of I...
  4. Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice.

    American Journal of Physiology - Gastrointestin... 306(5):G445 (2014) PMID 24407593 PMCID PMC3949022

    Intestinal intussusception (ISS) commonly causes intestinal obstruction in children. One mechanism that has been proposed to cause ISS is inflammation-induced alteration of intestinal motility. We investigated whether innate inflammatory factors or altered motility is required for induction of I...
  5. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.

    Molecular Neurodegeneration 9:28 (2014) PMID 25108425 PMCID PMC4132280

    Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology, Aβ is known to undergo active transport across the blood-brain barrier and cerebral amyloid angiopathy (CAA) is a prominent f...
  6. In vivo axonal transport deficits in a mouse model of fronto-temporal dementia

    NeuroImage: Clinical 4:711 (2014)

    Background Axonal transport is vital for neurons and deficits in this process have been previously reported in a few mouse models of Alzheimer's disease prior to the appearance of plaques and tangles. However, it remains to be determined whether axonal transport is defective ...
  7. Use of magnetization transfer contrast MRI to detect early molecular pathology in Alzheimer's disease.

    Magnetic Resonance in Medicine 71(1):333 (2014) PMID 23413044

    The purpose of this study was to determine if magnetization transfer contrast (MTC) imaging could be used to detect early macromolecular accumulation in a mouse model of early Alzheimer's disease. We obtained MTC images at 9.4 T at three different age points in the Tg2576 mouse model of Alzheime...
  8. Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells.

    Nanomedicine 9(8):1209 (2014) PMID 24063415 PMCID PMC4051872

    We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indoc...
  9. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.

    Molecular Neurodegeneration 9:28 (2014) PMID 25108425 PMCID PMC4132280

    Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology, Aβ is known to undergo active transport across the blood-brain barrier and cerebral amyloid angiopathy (CAA) is a prominent f...
  10. Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.

    FASEB Journal 28(1):364 (2014) PMID 24081904

    A major limitation of exogenous vitamin D3 administration for the treatment of prostate cancer is the marginal, if any, clinical efficacy. We dissected the basis for the resistance to the vitamin D3 antitumor properties and specifically examined the effect of its major catabolic enzyme, CYP24A1,...
  11. In vivo axonal transport deficits in a mouse model of fronto-temporal dementia.

    NeuroImage: Clinical 4:711 (2014) PMID 24936422 PMCID PMC4053640

    Axonal transport is vital for neurons and deficits in this process have been previously reported in a few mouse models of Alzheimer's disease prior to the appearance of plaques and tangles. However, it remains to be determined whether axonal transport is defective prior to the onset of neurodege...
  12. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.

    Molecular Neurodegeneration 9:28 (2014) PMID 25108425 PMCID PMC4132280

    Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology, Aβ is known to undergo active transport across the blood-brain barrier and cerebral amyloid angiopathy (CAA) is a prominent f...
  13. Use of magnetization transfer contrast MRI to detect early molecular pathology in Alzheimer's disease.

    Magnetic Resonance in Medicine 71(1):333 (2014) PMID 23413044

    The purpose of this study was to determine if magnetization transfer contrast (MTC) imaging could be used to detect early macromolecular accumulation in a mouse model of early Alzheimer's disease. We obtained MTC images at 9.4 T at three different age points in the Tg2576 mouse model of Alzheime...
  14. Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells.

    Nanomedicine 9(8):1209 (2014) PMID 24063415 PMCID PMC4051872

    We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indoc...
  15. Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.

    FASEB Journal 28(1):364 (2014) PMID 24081904

    A major limitation of exogenous vitamin D3 administration for the treatment of prostate cancer is the marginal, if any, clinical efficacy. We dissected the basis for the resistance to the vitamin D3 antitumor properties and specifically examined the effect of its major catabolic enzyme, CYP24A1,...
  16. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development.

    Human Molecular Genetics 22(5):879 (2013) PMID 23184148 PMCID PMC3606008

    Mutations in ZIC3 cause human X-linked heterotaxy and isolated cardiovascular malformations. A mouse model with targeted deletion of Zic3 demonstrates an early role for Zic3 in gastrulation, CNS, cardiac and left-right axial development. The observation of multiple malformations in Zic3(null) mi...
  17. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development.

    Human Molecular Genetics 22(5):879 (2013) PMID 23184148 PMCID PMC3606008

    Mutations in ZIC3 cause human X-linked heterotaxy and isolated cardiovascular malformations. A mouse model with targeted deletion of Zic3 demonstrates an early role for Zic3 in gastrulation, CNS, cardiac and left-right axial development. The observation of multiple malformations in Zic3(null) mi...
  18. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

    Journal of Neuroscience 33(4):1651 (2013) PMID 23345237 PMCID PMC3711605

    Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a component of some degenerative neurological disorders such as Alzheimer's disease (AD). Recently, the microtubule-binding protein tau has been implicated in the regulation of network synchronization. Genetic remov...
  19. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

    Journal of Neuroscience 33(4):1651 (2013) PMID 23345237 PMCID PMC3711605

    Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a component of some degenerative neurological disorders such as Alzheimer's disease (AD). Recently, the microtubule-binding protein tau has been implicated in the regulation of network synchronization. Genetic remov...
  20. Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury.

    ACS Nano 6(9):8007 (2012) PMID 22866916 PMCID PMC3458163

    Injury to the neurovasculature is a feature of brain injury and must be addressed to maximize opportunity for improvement. Cerebrovascular dysfunction, manifested by reduction in cerebral blood flow (CBF), is a key factor that worsens outcome after traumatic brain injury (TBI), most notably unde...