1. Gold Tailored Photosensitive Elastin-like Polymer: Synthesis of Temperature, pH and UV-vis Sensitive Probes.

    Macromolecular Rapid Communications 31(6):568 (2010) PMID 21590944

    Here, we describe a procedure to manufacture smart hybrid probes that exhibit tunable optical properties as a function of multiple environmental variations. Initially, we achieved a one-pot synthesis of gold-PREP (photo-responsive elastin-like polymer) conjugate Gold-AzoGlu15 via reduction of au...
  2. Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.

    Journal of Cell Science 123(Pt 1):62 (2010) PMID 20016067

    Cerebellar granular neuronal precursors (CGNPs) proliferate in response to the mitogenic activity of Sonic hedgehog (Shh), and this proliferation is negatively regulated by activation of cAMP-dependent protein kinase (PKA). In the basal state, the PKA catalytic subunits (C-PKA) are inactive beca...
  3. One-pot synthesis of pH and temperature sensitive gold clusters mediated by a recombinant elastin-like polymer

    European Polymer Journal 46(4):643 (2010)

  4. Expression of the proneural gene encoding Mash1 suppresses MYCN mitotic activity.

    Journal of Cell Science 122(Pt 5):595 (2009) PMID 19208763

    Murine Mash1 (Ascl1) is a member of the basic helix-loop-helix family of transcription factors and has been described to promote differentiation in some neural precursors. The process of differentiation is coordinated with a concomitant cell-cycle arrest, but the molecular mechanism of this proc...
  5. Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.

    Journal of Biological Chemistry 282(51):37170 (2007) PMID 17951258

    Nmyc is a potent regulator of cell cycle in cerebellar granular neuron precursors (CGNPs) and has been proposed to be the main effector of Shh (Sonic hedgehog) proliferative activity. Nmyc ectopic expression is sufficient to promote cell autonomous proliferation and can lead to tumorigenesis. Bo...
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  6. Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling.

    Development 131(13):3159 (2004) PMID 15197161

    During development of the cerebellum, sonic hedgehog (Shh) is directly responsible for the proliferation of granule cell precursors in the external germinal layer. We have looked for signals able to regulate a switch from the Shh-mediated proliferative response to one that directs differentiatio...