1. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

    EMBO Journal 35(13):1368 (2016) PMID 27145933 PMCID PMC4864280

    In hypoxic cells, dysfunctional mitochondria are selectively removed by a specialized autophagic process called mitophagy. The ER-mitochondrial contact site (MAM) is essential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein FUNDC1 interacts with LC3 ...
  2. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells.

    Molecular Medicine Reports 14(1):159 (2016) PMID 27176768 PMCID PMC4918616

    Diosmetin (Dio) is a major active component of flavonoid compounds. A previous study demonstrated that Dio exhibited anticancer activity and induced apoptosis in HepG2 human hepatoma cells via cytochrome P450, family 1-catalyzed metabolism. The present study observed that cell proliferation of H...
  3. Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP-2 and MMP-9.

    Molecular Medicine Reports 13(3):2401 (2016) PMID 26847170 PMCID PMC4768952

    Hepatocellular carcinoma (HCC) is one of the most malignant types of tumor worldwide with a high rate of mortality. Diosmetin (DIOS) exhibits various activities, including anticancer activities. However, the role of DIOS in the metastasis of HCC, and its underlying molecular mechanism, remain to...
  4. Smoking attitudes between smokers and non-smoker secondary school students in three geographic areas of China: a cross-sectional survey based on social cognitive theory

    The Lancet 386:S78 (2015)

    Background According to a 2014 China youth tobacco report, nearly 7% of junior secondary school students are using tobacco products and 30% of junior secondary school boys have tried tobacco products. The attitudes of secondary school students to smoking give insight into the...
  5. Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells.

    Molecular Medicine Reports 11(4):2459 (2015) PMID 25515619 PMCID PMC4337473

    Resveratrol, a non‑flavone polyphenol compound, has a chemopreventive and chemotherapeutic effect against the progression of multiple types of cancer, including lung cancer. However, the molecular mechanism underlying the effects of resveratrol on cancer remain to be elucidated. In the present s...
  6. Dihydromyricetin induces mouse hepatoma Hepal-6 cell apoptosis via the transforming growth factor-β pathway.

    Molecular Medicine Reports 11(3):1609 (2015) PMID 25376731 PMCID PMC4270327

    Dihydromyricetin (DHM) is a flavonoid compound which possesses potent antitumor activity. In the present study, it was demonstrated that DHM significantly inhibited proliferation and induced apoptosis in mouse hepatocellular carcinoma Hepal‑6 cells. Transforming growth factor β (TGF‑β) is recogn...
  7. Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma.

    Oncotarget 6(6):3669 (2015) PMID 25668819 PMCID PMC4414145

    The Notch signaling pathway plays a role in cell proliferation, differentiation. Emerging data have revealed aberrant Notch3 expression in hepatocellular carcinoma (HCC). However, whether Notch3 plays a role in tumorigenesis or tumor progression is unclear. In this study, we found that over 71.8...
  8. Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis.

    Molecular Medicine Reports 11(1):400 (2015) PMID 25333673

    Resveratrol (Res), a natural plant extract, is an effective inducer of cell apoptosis and cell cycle arrest in multiple carcinoma cell types, which has been demonstrated by its ability to inhibit the proliferation of multiple human tumor cells in vitro. Although Res possesses chemopreventive pro...
  9. Dihydromyricetin Enhances the Chemo-Sensitivity of Nedaplatin via Regulation of the p53/Bcl-2 Pathway in Hepatocellular Carcinoma Cells.

    PLoS ONE 10(4):e0124994 (2015) PMID 25915649 PMCID PMC4411137

    Chemotherapy is an effective weapon in the battle against cancer. Nedaplatin (NDP) is an improved platinum-containing drug with lower cytotoxicity than other similar drugs. However, the repeated use of NDP results in substantial hepatocyte damage as well as drug resistance in hepatocellular carc...
  10. ERRATUM: A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells.

    Scientific reports 5:7940 (2015) PMID 25588977 PMCID PMC4295101

  11. Evaluation of anti-smoking television advertising on tobacco control among urban community population in Chongqing, China.

    Tobacco Induced Diseases 13(1):31 (2015) PMID 26339225 PMCID PMC4558728

    China is the largest producer and consumer of tobacco in the world. Considering the constantly growing urban proportion, persuasive tobacco control measures are important in urban communities. Television, as one of the most pervasive mass media, can be used for this purpose. The anti-smoking adv...
  12. Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S‑phase cell cycle arrest and apoptosis through caspase/cyclin‑CDK pathways.

    Molecular Medicine Reports 10(4):1697 (2014) PMID 25050564 PMCID PMC4148380

    The present study compared the effect of resveratrol on HCT116 and Caco-2 human colon cancer cells. Annexin V/propidium iodide staining, MTT assay and western blot analysis revealed that resveratrol induced cycle arrest in the two cell lines, which was evidenced by cell cycle analysis and change...
  13. Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells.

    Oncology Reports 31(6):2713 (2014) PMID 24789439

    Dihydromyricetin (DHM) exhibits multiple pharmacological activities; however, the role of DHM in anti-melanoma activities and the underlying molecular mechanisms are unclear. The aim of the present study was to evaluate the effects of DHM on cell proliferation, cell cycle distribution and apopto...
  14. Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways.

    Food and Chemical Toxicology 66:7 (2014) PMID 24444546

    Dihydromyricetin (DHM), a bioactive flavonoid compound extracted from the stems and leaves of Ampelopsis grossedentata, has oxidation resistance, anti-tumor and free radical scavenging capabilities. In this study, we found that DHM-induced autophagy inhibited the cell proliferation in HepG2 cell...
  15. Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism.

    Scientific reports 4:4628 (2014) PMID 24717393 PMCID PMC3982169

    The development of antitumor chemotherapy drugs remains a key goal for oncologists, and natural products provide a vast resource for anti-cancer drug discovery. In the current study, we found that the flavonoid dihydromyricetin (DHM) exhibited antitumor activity against liver cancer cells, inclu...
  16. A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells.

    Scientific reports 4:7041 (2014) PMID 25391369 PMCID PMC4229672

    Reactive oxygen species (ROS) and cellular oxidant stress are considered inducers of carcinogenesis. However, the association of ROS with cancer is both complex and, at times, paradoxical. We assessed the effects of dihydromyricetin (DHM) on the induction of ROS accumulation and on the activatio...
  17. Oroxylin A accelerates liver regeneration in CCl₄-induced acute liver injury mice.

    PLoS ONE 8(8):e71612 (2013) PMID 23951204 PMCID PMC3738530

    Based on the previous research that oroxylin A can suppress inflammation, we investigated the hepatoprotective role of oroxylin A against CCl₄-induced liver damage in mice and then studied the possible alteration of the activities of cytokine signaling participating in liver regeneration. Wild t...
  18. Dihydromyricetin reduced Bcl-2 expression via p53 in human hepatoma HepG2 cells.

    PLoS ONE 8(11):e76886 (2013) PMID 24223706 PMCID PMC3817187

    Dihydromyricetin (DHM) is a major active ingredient of flavonoids compounds. It exhibited anticancer activity and induced apoptosis in human hepatocellular carcinoma HepG2 cells according to our previous data. In this study, we investigated whether p53 is involved in DHM-triggered viability inhi...
  19. Oxidative stress and liver disease.

    Hepatology Research 42(8):741 (2012) PMID 22489668

    In humans, oxidative stress and antioxidant defenses are the sum of a complicated network of enzymatic and non-enzymatic processes. Depending on the stage and severity of diseases, a patient's antioxidant armamentarium may increase as an appropriate response to an oxidant challenge, whereas othe...
  20. rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure.

    Laboratory Investigation 90(12):1737 (2010) PMID 20644519

    Acute liver failure (ALF) is a life-threatening disease that has proven difficult to cure. In Western countries, acetaminophen (APAP) poisoning is the most common cause of ALF. However, the mode of cell death in APAP-induced ALF cases is controversial. Previous studies have shown that administra...