1. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice.

    Phytomedicine 21(12):1638 (2014) PMID 25442271

    Cigarette smoking is the primary cause of chronic obstructive pulmonary disease (COPD), which is mediated by lung infiltration with inflammatory cells, enhanced oxidative stress, and tissue destruction. Anti-malarial drug artesunate has been shown to possess anti-inflammatory and anti-oxidative ...
  2. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice.

    Phytomedicine 21(12):1638 (2014) PMID 25442271

    Cigarette smoking is the primary cause of chronic obstructive pulmonary disease (COPD), which is mediated by lung infiltration with inflammatory cells, enhanced oxidative stress, and tissue destruction. Anti-malarial drug artesunate has been shown to possess anti-inflammatory and anti-oxidative ...
  3. Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes.

    Neuroreport 25(12):881 (2014) PMID 24949817

    Andrographolide is a bioactive molecule isolated from Andrographis paniculata with anticancer and anti-inflammatory activities. In this study, we tested the effects of andrographolide on astrocyte-mediated neuroinflammatory responses. Cultured rat primary astrocytes were treated with proinflamma...
  4. Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes.

    Neuroreport 25(12):881 (2014) PMID 24949817

    Andrographolide is a bioactive molecule isolated from Andrographis paniculata with anticancer and anti-inflammatory activities. In this study, we tested the effects of andrographolide on astrocyte-mediated neuroinflammatory responses. Cultured rat primary astrocytes were treated with proinflamma...
  5. Artemisinins: pharmacological actions beyond anti-malarial.

    Pharmacology & Therapeutics 142(1):126 (2014) PMID 24316259

    Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally derived from Artemisia annua L. The anti-malarial action of artemisinins involves the formation of free radicals via cleavage of the endoperoxide bond in its structure, which mediate eradication of the Pl...
  6. The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation.

    American Journal of Respiratory Cell and Molecu... 50(2):451 (2014) PMID 24066853

    Airway smooth muscle (ASM) cell hyperplasia contributes to airway wall remodeling (AWR) in asthma. Glucocorticoids, which are used as first-line therapy for the treatment of inflammation in asthma, have limited impact on AWR, and protracted usage of high doses of glucocorticoids is associated wi...
  7. Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation.

    Journal of Immunology 191(5):2691 (2013) PMID 23918989

    Persistent activation of NF-κB has been associated with the development of asthma. Receptor-interacting protein 2 (Rip2) is a transcriptional product of NF-κB activation. It is an adaptor protein with serine/threonine kinase activity and has been shown to positively regulate NF-κB activity. We i...
  8. Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models.

    Phytomedicine 20(10):853 (2013) PMID 23632085

    Allergy is an acquired hypersensitivity reaction of the immune system mediated by cross-linking of the allergen-specific IgE-bound high-affinity IgE receptors, leading to immediate mast cell degranulation. Rottlerin is an active molecule isolated from Mallotus philippinensis, a medicinal plant u...
  9. Metabolomics reveals altered metabolic pathways in experimental asthma.

    American Journal of Respiratory Cell and Molecu... 48(2):204 (2013) PMID 23144334

    Metabolomics refers to the comprehensive analysis of metabolites in biological systems, and has been employed to study patients with asthma based on their urinary metabolite profile. We hypothesize that airway allergic asthma would affect metabolism in the lungs, and could be detected in broncho...
  10. Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma.

    Free Radical Biology and Medicine 53(3):498 (2012) PMID 22634146

    Oxidative stress is a critical pathophysiological factor in the development of allergic airway inflammation, resulting in oxidative damage to lipids, proteins, and DNA. Our recent report revealed potent anti-inflammatory effects of the antimalarial drug artesunate in experimental allergic asthma...
  11. Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat.

    Shock 37(6):592 (2012) PMID 22392145

    Recent evidence suggests that cell therapy such as the injection of bone marrow-derived mononuclear cells (BMMNCs) can exert protective effects in various conditions associated with ischemia-reperfusion injury. Here, we investigate the effects of BMMNCs on the organ injury/dysfunction induced by...
  12. Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function.

    Journal of Allergy and Clinical Immunology 129(6):1611 (2012) PMID 22385629

    Previous studies have shown that CD8 T cells can both prevent and cause allergic responses. However, the underlying mechanisms remain to be elucidated. We aim to investigate the potential of CD8 T cells with different IFN-γ expressions to modulate the elicitation of allergic inflammation followi...
  13. Transcription factor E3, a major regulator of mast cell–mediated allergic response

    Journal of Allergy and Clinical Immunology 129(5):1357 (2012)

    Background Microphthalmia transcription factor, an MiT transcription family member closely related to transcription factor E3 (TFE3), is essential for mast cell development and survival. TFE3 was previously reported to play a role in the functions of B and T cells; however, i...
  14. Transcription factor E3, a major regulator of mast cell-mediated allergic response.

    Journal of Allergy and Clinical Immunology 129(5):1357 (2012) PMID 22360977

    Microphthalmia transcription factor, an MiT transcription family member closely related to transcription factor E3 (TFE3), is essential for mast cell development and survival. TFE3 was previously reported to play a role in the functions of B and T cells; however, its role in mast cells has not y...
  15. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.

    European Journal of Pharmacology 679(1-3):109 (2012) PMID 22290391

    Persistent activation of nuclear factor-κB (NF-κB) has been associated with the development of asthma. Fisetin (3,7,3',4'-tetrahydroxyflavone), a naturally occurring bioactive flavonol, has been shown to inhibit NF-κB activity. We hypothesized that fisetin may attenuate allergic asthma via negat...
  16. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.

    Clinical and Experimental Pharmacology and Phys... 39(3):300 (2012) PMID 22017767

    1. Andrographis paniculata (Burm. f) Nees, commonly known as 'king of bitters', is a herbaceous plant belonging to the Family Acanthaceae. It has been widely used for centuries in Asian countries like China, India, Thailand and Malaysia for the treatment of sore throat, flu and upper respiratory...
  17. Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.

    Journal of Natural Products 74(6):1484 (2011) PMID 21598983

    Our group recently reported novel anti-inflammatory effects of andrographolide (2), a bioactive molecule isolated from Andrographis paniculata, in a mouse asthma model. However, 2 has been shown to possess cytotoxic activity. 14-Deoxy-11,12-didehydroandrographolide (1) is an analogue of 2 that c...
  18. Sphingosine kinase and sphingosine 1-phosphate in asthma.

    Bioscience Reports 31(2):145 (2011) PMID 21091442

    Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade. Sphingolipid metabolites, such as cer...
  19. A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells.

    Journal Of Cellular Physiology 226(2):397 (2011) PMID 20665705

    Airway epithelium functions not only as a physical barrier, but also a regulator of lung inflammation. IFN-γ plays a critical role in airway inflammation associated with respiratory viral infection. We investigated differential protein profiling in IFN-γ-stimulated normal human bronchial epithel...
  20. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.

    PLoS ONE 6(6):e20932 (2011) PMID 21695271 PMCID PMC3111464

    Phosphoinositide 3-kinase (PI3K)/Akt pathway is linked to the development of asthma. Anti-malarial drug artesunate is a semi-synthetic derivative of artemisinin, the principal active component of a medicinal plant Artemisia annua, and has been shown to inhibit PI3K/Akt activity. We hypothesized ...