1. Natural selection in a postglacial range expansion: the case of the colour cline in the European barn owl.

    Molecular Ecology 23(22):5508 (2014) PMID 25294501

    Gradients of variation--or clines--have always intrigued biologists. Classically, they have been interpreted as the outcomes of antagonistic interactions between selection and gene flow. Alternatively, clines may also establish neutrally with isolation by distance (IBD) or secondary contact betw...
  2. Natural selection in a postglacial range expansion: the case of the colour cline in the European barn owl.

    Molecular Ecology 23(22):5508 (2014) PMID 25294501

    Gradients of variation-or clines-have always intrigued biologists. Classically, they have been interpreted as the outcomes of antagonistic interactions between selection and gene flow. Alternatively, clines may also establish neutrally with isolation by distance (IBD) or secondary contact betwee...
  3. Natural selection in a postglacial range expansion: the case of the colour cline in the European barn owl.

    Molecular Ecology 23(22):5508 (2014) PMID 25294501

    Gradients of variation--or clines--have always intrigued biologists. Classically, they have been interpreted as the outcomes of antagonistic interactions between selection and gene flow. Alternatively, clines may also establish neutrally with isolation by distance (IBD) or secondary contact betw...
  4. Regulation of 11β-hydroxysteroid dehydrogenase type 2 by microRNA.

    Hypertension 64(4):860 (2014) PMID 24980668

    The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is selectively expressed in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid receptor. A diminished activity causes salt-sensitive hypertension. The mechanism of the variable and distinct 11β-hy...
  5. Wheat alleles introgress into selfing wild relatives: empirical estimates from approximate Bayesian computation in Aegilops triuncialis.

    Molecular Ecology 23(20):5089 (2014) PMID 25223217

    Extensive gene flow between wheat (Triticum sp.) and several wild relatives of the genus Aegilops has recently been detected despite notoriously high levels of selfing in these species. Here, we assess and model the spread of wheat alleles into natural populations of the barbed goatgrass (Aegilo...
  6. Regulation of 11β-hydroxysteroid dehydrogenase type 2 by microRNA.

    Hypertension 64(4):860 (2014) PMID 24980668

    The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is selectively expressed in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid receptor. A diminished activity causes salt-sensitive hypertension. The mechanism of the variable and distinct 11β-hy...
  7. Wheat alleles introgress into selfing wild relatives: empirical estimates from approximate Bayesian computation in Aegilops triuncialis.

    Molecular Ecology 23(20):5089 (2014) PMID 25223217

    Extensive gene flow between wheat (Triticum sp.) and several wild relatives of the genus Aegilops has recently been detected despite notoriously high levels of selfing in these species. Here, we assess and model the spread of wheat alleles into natural populations of the barbed goatgrass (Aegilo...
  8. Sex-chromosome turnovers: the hot-potato model.

    American Naturalist 183(1):140 (2014) PMID 24334743

    Sex-determining systems often undergo high rates of turnover but for reasons that remain largely obscure. Two recent evolutionary models assign key roles, respectively, to sex-antagonistic (SA) mutations occurring on autosomes and to deleterious mutations accumulating on sex chromosomes. These t...
  9. Genome-wide prediction methods in highly diverse and heterozygous species: proof-of-concept through simulation in grapevine.

    PLoS ONE 9(11):e110436 (2014) PMID 25365338 PMCID PMC4217727

    Nowadays, genome-wide association studies (GWAS) and genomic selection (GS) methods which use genome-wide marker data for phenotype prediction are of much potential interest in plant breeding. However, to our knowledge, no studies have been performed yet on the predictive ability of these method...
  10. Sex-chromosome turnovers: the hot-potato model.

    American Naturalist 183(1):140 (2014) PMID 24334743

    Sex-determining systems often undergo high rates of turnover but for reasons that remain largely obscure. Two recent evolutionary models assign key roles, respectively, to sex-antagonistic (SA) mutations occurring on autosomes and to deleterious mutations accumulating on sex chromosomes. These t...
  11. Independent polled mutations leading to complex gene expression differences in cattle.

    PLoS ONE 9(3):e93435 (2014) PMID 24671182 PMCID PMC3966897

    The molecular regulation of horn growth in ruminants is still poorly understood. To investigate this process, we collected 1019 hornless (polled) animals from different cattle breeds. High-density SNP genotyping confirmed the presence of two different polled associated haplotypes in Simmental an...
  12. Independent polled mutations leading to complex gene expression differences in cattle.

    PLoS ONE 9(3):e93435 (2014) PMID 24671182 PMCID PMC3966897

    The molecular regulation of horn growth in ruminants is still poorly understood. To investigate this process, we collected 1019 hornless (polled) animals from different cattle breeds. High-density SNP genotyping confirmed the presence of two different polled associated haplotypes in Simmental an...
  13. Genome-Wide Prediction Methods in Highly Diverse and Heterozygous Species: Proof-of-Concept through Simulation in Grapevine.

    PLoS ONE 9(11):e110436 (2014) PMID 25365338 PMCID PMC4217727

    Nowadays, genome-wide association studies (GWAS) and genomic selection (GS) methods which use genome-wide marker data for phenotype prediction are of much potential interest in plant breeding. However, to our knowledge, no studies have been performed yet on the predictive ability of these method...
  14. Genome-wide prediction methods in highly diverse and heterozygous species: proof-of-concept through simulation in grapevine.

    PLoS ONE 9(11):e110436 (2014) PMID 25365338 PMCID PMC4217727

    Nowadays, genome-wide association studies (GWAS) and genomic selection (GS) methods which use genome-wide marker data for phenotype prediction are of much potential interest in plant breeding. However, to our knowledge, no studies have been performed yet on the predictive ability of these method...
  15. Sex-chromosome turnovers induced by deleterious mutation load.

    Evolution 67(3):635 (2013) PMID 23461315

    In sharp contrast with mammals and birds, many cold-blooded vertebrates present homomorphic sex chromosomes. Empirical evidence supports a role for frequent turnovers, which replace nonrecombining sex chromosomes before they have time to decay. Three main mechanisms have been proposed for such t...
  16. Sex-chromosome turnovers induced by deleterious mutation load.

    Evolution 67(3):635 (2013) PMID 23461315

    In sharp contrast with mammals and birds, many cold-blooded vertebrates present homomorphic sex chromosomes. Empirical evidence supports a role for frequent turnovers, which replace nonrecombining sex chromosomes before they have time to decay. Three main mechanisms have been proposed for such t...
  17. The balanced lethal system of crested newts: a ghost of sex chromosomes past?

    American Naturalist 180(6):E174 (2012) PMID 23149410

    Balanced lethal systems are more than biological curiosities: as theory predicts, they should quickly be eliminated through the joint forces of recombination and selection. That such systems might become fixed in natural populations poses a challenge to evolutionary theory. Here we address the c...
  18. The balanced lethal system of crested newts: a ghost of sex chromosomes past?

    American Naturalist 180(6):E174 (2012) PMID 23149410

    Balanced lethal systems are more than biological curiosities: as theory predicts, they should quickly be eliminated through the joint forces of recombination and selection. That such systems might become fixed in natural populations poses a challenge to evolutionary theory. Here we address the c...
  19. The evolution of XY recombination: sexually antagonistic selection versus deleterious mutation load.

    Evolution 66(10):3155 (2012) PMID 23025605

    Recombination arrest between X and Y chromosomes, driven by sexually antagonistic genes, is expected to induce their progressive differentiation. However, in contrast to birds and mammals (which display the predicted pattern), most cold-blooded vertebrates have homomorphic sex chromosomes. Two m...
  20. The evolution of XY recombination: sexually antagonistic selection versus deleterious mutation load.

    Evolution 66(10):3155 (2012) PMID 23025605

    Recombination arrest between X and Y chromosomes, driven by sexually antagonistic genes, is expected to induce their progressive differentiation. However, in contrast to birds and mammals (which display the predicted pattern), most cold-blooded vertebrates have homomorphic sex chromosomes. Two m...