1. PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: perspectives in the diagnosis of pancreatic cancer.

    Digestive and Liver Disease 47(2):138 (2015) PMID 25454709

    Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to ve...
  2. Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.

    Hepatology 60(4):1324 (2014) PMID 24925797

    The activation of the biliary stem-cell signaling pathway hairy and enhancer of split 1/pancreatic duodenal homeobox-1 (Hes-1/PDX-1) in mature cholangiocytes determines cell proliferation. Neurogenin-3 (Ngn-3) is required for pancreas development and ductal cell neogenesis. PDX-1-dependent activ...
  3. VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: the ALICE-1 study.

    International Journal of Cancer 135(5):1247 (2014) PMID 24510746

    Although new treatment modalities changed the global approach to hepatocellular carcinoma (HCC), this disease still represents a medical challenge. Currently, the therapeutic stronghold is sorafenib, a tyrosine kinase inhibitor (TKI) directed against the vascular endothelial growth factor (VEGF)...
  4. Role of NADPH oxidases in liver fibrosis.

    Antioxidants and Redox Signaling 20(17):2854 (2014) PMID 24040957 PMCID PMC4026397

    Hepatic fibrosis is the common pathophysiologic process resulting from chronic liver injury, characterized by the accumulation of an excessive extracellular matrix. Multiple lines of evidence indicate that oxidative stress plays a pivotal role in the pathogenesis of liver fibrosis. Nicotinamide ...
  5. Role of NADPH oxidases in liver fibrosis.

    Antioxidants and Redox Signaling 20(17):2854 (2014) PMID 24040957 PMCID PMC4026397

    Hepatic fibrosis is the common pathophysiologic process resulting from chronic liver injury, characterized by the accumulation of an excessive extracellular matrix. Multiple lines of evidence indicate that oxidative stress plays a pivotal role in the pathogenesis of liver fibrosis. Nicotinamide ...
  6. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice.

    Hepatology 59(5):1738 (2014) PMID 23959503

    Nonalcoholic fatty liver disease (NAFLD) may lead to hepatic fibrosis. Dietary habits affect gut microbiota composition, whereas endotoxins produced by Gram-negative bacteria stimulate hepatic fibrogenesis. However, the mechanisms of action and the potential effect of microbiota in the liver are...
  7. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.

    Nature Communications 5:4451 (2014) PMID 25043713 PMCID PMC4107319

    Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are suppressed. Here we report the discovery of a sig...
  8. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.

    Nature Communications 5:4451 (2014) PMID 25043713 PMCID PMC4107319

    Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are suppressed. Here we report the discovery of a sig...
  9. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.

    Nature Communications 5:4451 (2014) PMID 25043713 PMCID PMC4107319

    Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are suppressed. Here we report the discovery of a sig...
  10. The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management.

    BMC Cancer 14:110 (2014) PMID 24552144 PMCID PMC3930857

    In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of tumour hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is an important predictive factor in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoem...
  11. HCC development is associated to peripheral insulin resistance in a mouse model of NASH.

    PLoS ONE 9(5):e97136 (2014) PMID 24853141 PMCID PMC4031080

    NAFLD is the most common liver disease worldwide but it is the potential evolution to NASH and eventually to hepatocellular carcinoma (HCC), even in the absence of cirrhosis, that makes NAFLD of such clinical importance. we aimed to create a mouse model reproducing the pathological spectrum of N...
  12. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.

    Hepatology 58(4):1461 (2013) PMID 23553591 PMCID PMC3848418

    Although it is well established that hepatic macrophages play a crucial role in the development of liver fibrosis, the underlying mechanisms remain largely elusive. Moreover, it is not known whether other mononuclear phagocytes such as dendritic cells (DCs) contribute to hepatic stellate cell (H...
  13. Semaphorin 7A Contributes to TGF-β–Mediated Liver Fibrogenesis

    The American Journal of Pathology 183(3):820 (2013)

    Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis. Liver injury was induced in vivo by carbon tetrachloride i.p. injection or...
  14. Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.

    The American Journal of Pathology 183(3):820 (2013) PMID 23850082

    Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis. Liver injury was induced in vivo by carbon tetrachloride i.p. injection or bile duct...
  15. New insights in hepatocellular carcinoma: from bench to bedside.

    Annals of translational medicine 1(2):15 (2013) PMID 25332959 PMCID PMC4200632

    Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocyte. The liver is one of the main targets for different metastatic foci, but it represents an important and frequent locus of degeneration in the cou...
  16. Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma

    Digestive and Liver Disease 45(6):450 (2013)

    Hepatocellular carcinoma and cholangiocarcinoma are primary liver cancers, both represent a growing challenge for clinicians due to their increasing morbidity and mortality. In the last few years a number of in vivo models of hepatocellular carcinoma and cholangiocarcinoma ha...
  17. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma.

    Digestive and Liver Disease 45(6):450 (2013) PMID 23177172 PMCID PMC3716909

    Hepatocellular carcinoma and cholangiocarcinoma are primary liver cancers, both represent a growing challenge for clinicians due to their increasing morbidity and mortality. In the last few years a number of in vivo models of hepatocellular carcinoma and cholangiocarcinoma have been developed. T...
  18. 198 PDX-1 mRNA Expression in Endoscopic Ultrasound-Guided Fine Needle Cytoaspirate As a New Marker for the Diagnosis of Pancreatic Cancer

    Gastrointestinal Endoscopy 77(5):AB135 (2013)

  19. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis.

    Journal of Hepatology 58(4):750 (2013) PMID 23207146

    Cholangiocyte proliferation plays a role in the progression of cholangiopathies, in particular in primary sclerosing cholangitis. The mechanisms regulating cholangiocyte proliferation are still undefined. Pancreatic Duodenal Homeobox protein 1 (PDX-1) is expressed by reactive cholangiocytes. In ...
  20. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: Possible implications for sclerosing cholangitis

    Journal of Hepatology 58(4):750 (2013)

    Background & Aims Cholangiocyte proliferation plays a role in the progression of cholangiopathies, in particular in primary sclerosing cholangitis. The mechanisms regulating cholangiocyte proliferation are still undefined. Pancreatic Duodenal Homeobox protein 1 (PDX-1) is exp...