1. Primary malignant pulmonary tumors in children: a review of the national cancer data base.

    Journal of Pediatric Surgery 50(6):1004 (2015) PMID 25812444

    The purpose is to delineate the clinical and pathological characteristics of rare primary malignant pulmonary tumors in children. Utilizing the National Cancer Data Base (NCDB), we analyzed all children (≤ 18 years) with a primary malignant pulmonary tumor from 1998 to 2011 to identify factors a...
  2. Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?

    Journal of Pediatric Surgery 50(6):1009 (2015) PMID 25819020

    Treatment of pediatric papillary thyroid cancer (p-PTC) often follows adult guidelines, including total thyroidectomy for tumors >1cm. This study examined the association between operation type and overall survival (OS) for tumors >1cm in size in the pediatric population. Patients ≤ 21 years of ...
  3. Congenital left paraduodenal hernia causing chronic abdominal pain and abdominal catastrophe.

    Pediatrics 135(4):e1067 (2015) PMID 25802350

    Paraduodenal hernias are the most common type of congenital internal hernia. Because of its overall rare incidence, this entity is often overlooked during initial assessment of the patient. Lack of specific diagnostic criteria also makes diagnosis exceedingly difficult, and the resulting diagnos...
  4. Focal nodular hyperplasia in children: An institutional experience with review of the literature

    Journal of Pediatric Surgery 50(3):382 (2015)

    Background Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We present a review of all children with a tissue diagnosis of FNH at our institution, describe the diagnostic modalities, and provi...
  5. Focal nodular hyperplasia in children: An institutional experience with review of the literature.

    Journal of Pediatric Surgery 50(3):382 (2015) PMID 25746693

    Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We present a review of all children with a tissue diagnosis of FNH at our institution, describe the diagnostic modalities, and provide recommendations for diagnosi...
  6. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling.

    Apoptosis 20(1):50 (2015) PMID 25425103

    High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR in...
  7. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling.

    Apoptosis 20(1):50 (2015) PMID 25425103

    High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR in...
  8. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling.

    Apoptosis 20(1):50 (2015) PMID 25425103

    High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR in...
  9. Parathyroid carcinoma in more than 1,000 patients: A population-level analysis.

    Surgery 156(6):1622 (2014) PMID 25456964

    Parathyroid carcinoma (PC) is a rare malignancy with a moderate prognosis. The staging system, prognostic indicators, and optimal surgical management are still under debate. This large cohort explores prognostic factors for PC. 1,022 cases of PC in the 1998-2011 National Cancer Data Base that un...
  10. Parathyroid carcinoma in more than 1,000 patients: A population-level analysis.

    Surgery 156(6):1622 (2014) PMID 25456964

    Parathyroid carcinoma (PC) is a rare malignancy with a moderate prognosis. The staging system, prognostic indicators, and optimal surgical management are still under debate. This large cohort explores prognostic factors for PC. 1,022 cases of PC in the 1998-2011 National Cancer Data Base that un...
  11. Parathyroid carcinoma in more than 1,000 patients: A population-level analysis.

    Surgery 156(6):1622 (2014) PMID 25456964

    Parathyroid carcinoma (PC) is a rare malignancy with a moderate prognosis. The staging system, prognostic indicators, and optimal surgical management are still under debate. This large cohort explores prognostic factors for PC. 1,022 cases of PC in the 1998-2011 National Cancer Data Base that un...
  12. Resource utilization after gastrostomy tube placement: defining areas of improvement for future quality improvement projects.

    Journal of Pediatric Surgery 49(11):1598 (2014) PMID 25475801

    Gastrostomy tube (GT) placement is a frequent procedure at a tertiary care children's hospital. Because of underlying patient illness and the nature of the device, patients often require multiple visits to the emergency room for GT-related concerns. We hypothesized that the majority of our patie...
  13. Resource utilization after gastrostomy tube placement: Defining areas of improvement for future quality improvement projects.

    Journal of Pediatric Surgery 49(11):1598 (2014) PMID 25475801

    Gastrostomy tube (GT) placement is a frequent procedure at a tertiary care children's hospital. Because of underlying patient illness and the nature of the device, patients often require multiple visits to the emergency room for GT-related concerns. We hypothesized that the majority of our patie...
  14. Resource utilization after gastrostomy tube placement: defining areas of improvement for future quality improvement projects.

    Journal of Pediatric Surgery 49(11):1598 (2014) PMID 25475801

    Gastrostomy tube (GT) placement is a frequent procedure at a tertiary care children's hospital. Because of underlying patient illness and the nature of the device, patients often require multiple visits to the emergency room for GT-related concerns. We hypothesized that the majority of our patie...
  15. Relapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging.

    Pediatric Radiology 44(10):1275 (2014) PMID 24839140

    Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk of radiation-induced cancer. The purpose of this study was to determine the utility of surveillance CT scans compared to serum alpha-fetoprotein (AFP...
  16. Relapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging.

    Pediatric Radiology 44(10):1275 (2014) PMID 24839140

    Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk of radiation-induced cancer. The purpose of this study was to determine the utility of surveillance CT scans compared to serum alpha-fetoprotein (AFP...
  17. Identifying and reducing early complications of surgical central lines in infants and toddlers.

    Journal of Surgical Research 190(1):246 (2014) PMID 24811915

    Hospitalized infants>1 y old often require central venous catheters (CVC) for prolonged therapy. There are limited data describing the complication profile for this young population. The purpose of this study was to review outcomes associated with CVC insertion in this high-risk group and compar...
  18. Identifying and reducing early complications of surgical central lines in infants and toddlers.

    Journal of Surgical Research 190(1):246 (2014) PMID 24811915

    Hospitalized infants>1 y old often require central venous catheters (CVC) for prolonged therapy. There are limited data describing the complication profile for this young population. The purpose of this study was to review outcomes associated with CVC insertion in this high-risk group and compar...
  19. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy.

    Apoptosis 18(10):1224 (2013) PMID 23700229 PMCID PMC3778057

    Treatment failure in high risk neuroblastoma is largely due to development of chemoresistance. NF-κB activation is one of the resistance mechanisms for cancer cells to escape from chemotherapy-induced cell-death. TAK1 is an essential component in genotoxic stresses-induced NF-κB activation; howe...
  20. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy.

    Apoptosis 18(10):1224 (2013) PMID 23700229 PMCID PMC3778057

    Treatment failure in high risk neuroblastoma is largely due to development of chemoresistance. NF-κB activation is one of the resistance mechanisms for cancer cells to escape from chemotherapy-induced cell-death. TAK1 is an essential component in genotoxic stresses-induced NF-κB activation; howe...