Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Journal of Hepatology 65(2):325 (2016)
Pediatric liver cancer is a rare but serious disease whose incidence is rising, and for which the therapeutic options are limited. Development of more targeted, less toxic therapies is hindered by the lack of an experimental animal model that captures the heterogeneity and metastatic capability ...
Colorectal carcinoma in pediatric patients: A comparison with adult tumors, treatment and outcomes from the National Cancer Database.
Journal of Pediatric Surgery 51(7):1061 (2016)
Pediatric colorectal cancer (CRC) is rare. Comparison with adult CRC tumors, management, and outcomes may identify opportunities for improvement in pediatric CRC care.
CRC patients in the National Cancer Data Base from 1998 to 2011, were grouped into Pediatric (≤21years), early onset adult (22-5...
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature.
Journal of Pediatric Hematology/Oncology 38(4):261 (2016)
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive pediatric malignancy. The purpose of this study was to review the clinical, radiologic, and pathologic features and outcome of children with UESL at our institution, in the United Network of Organ Sharing database an...
Relapsed hepatoblastoma confined to the lung is effectively treated with pulmonary metastasectomy.
Journal of Pediatric Surgery 51(4):525 (2016)
In children diagnosed with hepatoblastoma (HB), the lungs are the most common site of metastasis at both initial presentation and relapse. Previous studies have encouraged pulmonary metastasectomy to achieve a disease-free state after resection of the primary hepatic lesion. However, there is no...
Primitive Myxoid Mesenchymal Tumor of Infancy Involving Chest Wall in an Infant: A Case Report and Clinicopathologic Correlation.
Pediatric and Developmental Pathology 19(3):244 (2016)
Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare mesenchymal tumor of early childhood characterized by aggressive local infiltration of surrounding structures, rare metastases, and poor response to chemotherapy. Surgery alone appears to be the most effective treatment given the la...
Intraoperative ultrasound for liver tumor resection in children.
Journal of Surgical Research 198(2):418 (2015)
Primary hepatic neoplasms in children are rare tumors. All malignant and medically refractive benign primary pediatric liver tumors ultimately require surgical resection for cure. Accurate preoperative imaging including multidetector helical computerized tomography or magnetic resonance imaging ...
Management of appendiceal carcinoid tumors in children.
Journal of Surgical Research 198(2):384 (2015)
Appendiceal carcinoid tumors, also know as well-differentiated neuroendocrine neoplasms, are rare lesions detected incidentally after appendectomy in children. There are limited data about the natural history of these tumors, and guidelines regarding family counseling and need for additional sur...
Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?
Journal of Pediatric Surgery 50(6):1009 (2015)
Treatment of pediatric papillary thyroid cancer (p-PTC) often follows adult guidelines, including total thyroidectomy for tumors >1cm. This study examined the association between operation type and overall survival (OS) for tumors >1cm in size in the pediatric population.
Patients ≤ 21 years of ...
Primary malignant pulmonary tumors in children: a review of the national cancer data base.
Journal of Pediatric Surgery 50(6):1004 (2015)
The purpose is to delineate the clinical and pathological characteristics of rare primary malignant pulmonary tumors in children.
Utilizing the National Cancer Data Base (NCDB), we analyzed all children (≤ 18 years) with a primary malignant pulmonary tumor from 1998 to 2011 to identify factors a...
Congenital left paraduodenal hernia causing chronic abdominal pain and abdominal catastrophe.
Pediatrics 135(4):e1067 (2015)
Paraduodenal hernias are the most common type of congenital internal hernia. Because of its overall rare incidence, this entity is often overlooked during initial assessment of the patient. Lack of specific diagnostic criteria also makes diagnosis exceedingly difficult, and the resulting diagnos...
Focal nodular hyperplasia in children: an institutional experience with review of the literature.
Journal of Pediatric Surgery 50(3):382 (2015)
Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We present a review of all children with a tissue diagnosis of FNH at our institution, describe the diagnostic modalities, and provide recommendations for diagnosi...
mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling.
Apoptosis 20(1):50 (2015)
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR in...
Parathyroid carcinoma in more than 1,000 patients: A population-level analysis.
Surgery 156(6):1622 (2014)
Parathyroid carcinoma (PC) is a rare malignancy with a moderate prognosis. The staging system, prognostic indicators, and optimal surgical management are still under debate. This large cohort explores prognostic factors for PC.
1,022 cases of PC in the 1998-2011 National Cancer Data Base that un...
Resource utilization after gastrostomy tube placement: defining areas of improvement for future quality improvement projects.
Journal of Pediatric Surgery 49(11):1598 (2014)
Gastrostomy tube (GT) placement is a frequent procedure at a tertiary care children's hospital. Because of underlying patient illness and the nature of the device, patients often require multiple visits to the emergency room for GT-related concerns. We hypothesized that the majority of our patie...
Relapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging.
Pediatric Radiology 44(10):1275 (2014)
Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk of radiation-induced cancer.
The purpose of this study was to determine the utility of surveillance CT scans compared to serum alpha-fetoprotein (AFP...
Identifying and reducing early complications of surgical central lines in infants and toddlers.
Journal of Surgical Research 190(1):246 (2014)
Hospitalized infants>1 y old often require central venous catheters (CVC) for prolonged therapy. There are limited data describing the complication profile for this young population. The purpose of this study was to review outcomes associated with CVC insertion in this high-risk group and compar...
TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy.
Apoptosis 18(10):1224 (2013)
Treatment failure in high risk neuroblastoma is largely due to development of chemoresistance. NF-κB activation is one of the resistance mechanisms for cancer cells to escape from chemotherapy-induced cell-death. TAK1 is an essential component in genotoxic stresses-induced NF-κB activation; howe...
Cytogenetic analysis in the diagnosis and management of lipoblastomas: results from a single institution.
Journal of Surgical Research 184(1):341 (2013)
Lipoblastomas are rare, benign, soft tissue tumors that occur primarily in young children. Treatment includes complete excision and surveillance for recurrence. Lipoblastomas can be indistinguishable from other benign lipomatous tumors and liposarcomas. Cytogenetic analysis can provide the defin...
Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature.
Journal of Pediatric Surgery 48(2):436 (2013)
Non-Hodgkin's Lymphoma (NHL) is the most common intestinal malignancy in children, and Burkitt's lymphoma is the most frequently encountered histologic subtype. In pediatric patients, intestinal involvement of the lymphoma is a common finding. As over half of these intestinal tumors are unresect...
Primary malignant pancreatic neoplasms in children and adolescents: a 20 year experience.
Journal of Pediatric Surgery 47(12):2199 (2012)
Malignant pancreatic neoplasms in children and adolescents are rare. The clinical presentation, pathologic characteristics, management, and outcomes at two institutions are discussed.
We retrospectively reviewed all pediatric patients (age <= 18 years) treated for malignant pancreatic neoplasms ...