Steady Increase In Prices For Oral Anticancer Drugs After Market Launch Suggests A Lack Of Competitive Pressure.
Health Affairs 35(5):805 (2016)
The cost of treating cancer has risen to unprecedented heights, putting tremendous financial pressure on patients, payers, and society. Previous studies have documented the rising prices of cancer drugs at launch, but less critical attention has been paid to the cost of these drugs after launch....
The Clinical and Economic Impacts of Skeletal-Related Events Among Medicare Enrollees With Prostate Cancer Metastatic to Bone.
Oncologist 21(3):320 (2016)
Approximately 40% of men diagnosed with metastatic prostate cancer experience one or more skeletal-related events (SREs), defined as a pathological fracture, spinal cord compression, or surgery or radiotherapy to the bone. Accurate assessment of their effect on survival, health care resource uti...
Advanced Imaging and Receipt of Guideline Concordant Care in Women with Early Stage Breast Cancer.
International Journal of Breast Cancer 2016:2182985 (2016)
Objective. It is unknown whether advanced imaging (AI) is associated with higher quality breast cancer (BC) care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washing...
Role of Health Services Research in Producing High-Value Rehabilitation Care.
Physical Therapy 95(12):1703 (2015)
The concept of value is receiving greater attention in rehabilitation and the broader health care environment. The overall purpose of this article is to present a framework to help clinicians, researchers, educators, and policy makers better understand the role of health services research in dev...
Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis: A Systematic Review and Meta-analysis.
Annals of Internal Medicine 163(5):373 (2015)
Use of epidural corticosteroid injections is increasing.
To review evidence on the benefits and harms of epidural corticosteroid injections in adults with radicular low back pain or spinal stenosis of any duration.
Ovid MEDLINE (through May 2015), Cochrane Central Register of Controlled Trials, ...
Private sector risk-sharing agreements in the United States: trends, barriers, and prospects.
The American journal of managed care 21(9):632 (2015)
Risk-sharing agreements (RSAs) between drug manufacturers and payers link coverage and reimbursement to real-world performance or utilization of medical products. These arrangements have garnered considerable attention in recent years. However, greater use outside the United States raises questi...
The Authors Respond.
Journal of managed care & specialty pharmacy 21(9):844 (2015)
Sedative Hypnotic Medication Use and the Risk of Motor Vehicle Crash.
American Journal of Public Health 105(8):e64 (2015)
We sought to estimate the association between sedative hypnotic use and motor vehicle crash risk.
We conducted a new user cohort study of 409 171 adults in an integrated health care system. Health plan data were linked to driver license and collision records. Participants were aged 21 years or o...
Projected Clinical, Resource Use, and Fiscal Impacts of Implementing Low-Dose Computed Tomography Lung Cancer Screening in Medicare.
Journal of Oncology Practice 11(4):267 (2015)
The Centers for Medicare and Medicaid Services (CMS) recently issued a national coverage determination that provides reimbursement for low-dose computed tomography (CT) lung cancer screening for enrollees age 55 to 77 years with ≥ 30-pack-year smoking history who currently smoke or quit in the l...
A multifaceted hospitalist quality improvement intervention: Decreased frequency of common labs.
Journal Of Hospital Medicine 10(6):390 (2015)
Common labs such as a daily complete blood count or a daily basic metabolic panel represent possible waste and have been targeted by professional societies and the Choosing Wisely campaign for critical evaluation. We undertook a multifaceted quality-improvement (QI) intervention in a large commu...
Imaging Techniques for the Diagnosis of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.
Annals of Internal Medicine 162(10):697 (2015)
Several imaging modalities are available for diagnosis of hepatocellular carcinoma (HCC).
To evaluate the test performance of imaging modalities for HCC.
MEDLINE (1998 to December 2014), the Cochrane Library Database, Scopus, and reference lists.
Studies on test performance of ultrasonography, c...
Design, implementation, and first-year outcomes of a value-based drug formulary.
Journal of managed care & specialty pharmacy 21(4):269 (2015)
Value-based insurance design attempts to align drug copayment tier with value rather than cost. Previous implementations of value-based insurance design have lowered copayments for drugs indicated for select "high value" conditions and have found modest improvements in medication adherence. Howe...
Association of early imaging for back pain with clinical outcomes in older adults.
JAMA 313(11):1143 (2015)
In contrast to the recommendations for younger adults, many guidelines allow for older adults with back pain to undergo imaging without waiting 4 to 6 weeks. However, early imaging may precipitate interventions that do not improve outcomes.
To compare function and pain at the 12-month follow-up ...
Cost-effectiveness analysis alongside clinical trials II-An ISPOR Good Research Practices Task Force report.
Value in Health 18(2):161 (2015)
Clinical trials evaluating medicines, medical devices, and procedures now commonly assess the economic value of these interventions. The growing number of prospective clinical/economic trials reflects both widespread interest in economic information for new technologies and the regulatory and re...
Economic evaluation of tocilizumab monotherapy compared to adalimumab monotherapy in the treatment of severe active rheumatoid arthritis.
Value in Health 18(2):173 (2015)
To estimate the cost-effectiveness of tocilizumab (TCZ) monotherapy (Mono) versus adalimumab (ADA) Mono from the US payer perspective in patients with rheumatoid arthritis for whom methotrexate is inappropriate.
We compared TCZ Mono (8 mg/kg monthly) with ADA Mono (40 mg every other week), using...
The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.
Annals of Internal Medicine 162(4):276 (2015)
Increases in prescriptions of opioid medications for chronic pain have been accompanied by increases in opioid overdoses, abuse, and other harms and uncertainty about long-term effectiveness.
To evaluate evidence on the effectiveness and harms of long-term (>3 months) opioid therapy for chronic ...
Comparative effectiveness of imaging modalities to determine metastatic breast cancer treatment response.
The Breast 24(1):3 (2015)
We performed a systematic review to address the comparative effectiveness of different imaging modalities in evaluating treatment response among metastatic breast cancer patients. We searched seven multidisciplinary electronic databases for relevant publications (January 2003-December 2013) and ...
Cost-effectiveness: the authors reply.
Health Affairs 34(1):188 (2015)
Evaluating treatments and corresponding costs of prostate cancer patients treated within an inpatient or hospital-based outpatient setting.
Future Oncology 11(3):439 (2015)
To describe treatments and cost of care for prostate cancer (PCa) in hospital-based outpatient and inpatient settings.
Hospital encounters associated with PCa (ICD-9 codes 185, 233.4) and PCa-related treatment in a hospital claims database were included.
There were 211,440 encounters for PCa bet...
Health care costs among renal cancer patients using pazopanib and sunitinib.
Journal of managed care & specialty pharmacy 21(1):37 (2015)
Pazopanib was noninferior to sunitinib in progression-free survival in a phase III, open-label, randomized clinical trial comparing the efficacy and safety of the 2 drugs for treatment of patients with advanced renal cell carcinoma (RCC). A secondary analysis of this trial conducted on patient-r...