1. Matricellular protein CCN3 mitigates abdominal aortic aneurysm.

    Journal of Clinical Investigation 126(5):2012 (2016) PMID 27135882 PMCID PMC4855942

  2. Matricellular protein CCN3 mitigates abdominal aortic aneurysm.

    Journal of Clinical Investigation 126(4):1282 (2016) PMID 26974158 PMCID PMC4811126

    Abdominal aortic aneurysm (AAA) is a major cause of morbidity and mortality; however, the mechanisms that are involved in disease initiation and progression are incompletely understood. Extracellular matrix proteins play an integral role in modulating vascular homeostasis in health and disease. ...
  3. What Do We Learn from the Molecular Self-Assembly Process?

    Chemical Record 15(6):1144 (2015) PMID 26310610

    What Do We Learn from the Molecular Self-Assembly Process? Copyright © 2015 The Chemical Society of Japan and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
  4. Self-Assembly Process of Dodecanuclear Pt(II)-Linked Cyclic Hexagon.

    Journal of the American Chemical Society 137(24):7664 (2015) PMID 26038883

    The self-assembly process of a Pt(II)-linked hexagonal macrocycle consisting of six linear dinuclear Pt(II) units and six organic ditopic bent ligands was investigated. The process was monitored by (1)H NMR, and the intermediates in the self-assembly were analyzed by the n-k analysis. It was fou...
  5. Reduced NOV/CCN3 Expression Limits Inflammation and Interstitial Renal Fibrosis after Obstructive Nephropathy in Mice.

    PLoS ONE 10(9):e0137876 (2015) PMID 26367310 PMCID PMC4569074

    The main hallmark of chronic kidney disease (CKD) is excessive inflammation leading to interstitial tissue fibrosis. It has been recently reported that NOV/CCN3 could be involved in kidney damage but its role in the progression of nephropathies is poorly known. NOV/CCN3 is a secreted multifuncti...
  6. Mesityllithium and p-(dimethylamino)phenyllithium for the selective alternate trilithiation of the hexaphenylbenzene framework.

    Chemical Communications 50(72):10420 (2014) PMID 25046148

    We report mesityllithium and p-(dimethylamino)phenyllithium as new valuable lithiating reagents, which realize Br/Li exchange reaction of bromoarenes at relatively high temperature in THF. With these reagents, we established the general and practical protocols for the selective alternate trilith...
  7. Selective alternate derivatization of the hexaphenylbenzene framework through a thermodynamically controlled halogen dance.

    Organic Letters 16(3):1024 (2014) PMID 24450929

    We report a practical synthetic protocol and mechanistic details for the selective alternate derivatization of the hexaphenylbenzene (HPB) framework through a thermodynamically controlled halogen dance. The stability of the alternately trilithiated species of HPB is interpreted by the through-sp...
  8. CCN3 protein participates in bone regeneration as an inhibitory factor.

    Journal of Biological Chemistry 288(27):19973 (2013) PMID 23653360 PMCID PMC3707697

    CCN3, a member of the CCN protein family, inhibits osteoblast differentiation in vitro. However, the role of CCN3 in bone regeneration has not been well elucidated. In this study, we investigated the role of CCN3 in bone regeneration. We identified the Ccn3 gene by microarray analysis as a highl...
  9. In-water truly monodisperse aggregation of gear-shaped amphiphiles based on hydrophobic surface engineering.

    Journal of the American Chemical Society 132(38):13223 (2010) PMID 20815344

    Exactly six gear-shaped amphiphiles self-assemble into a highly stable, water-soluble, box-shaped capsule, in which indented hydrophobic surfaces of the components mesh with each other like gears. A water-soluble, tetrahedron-shaped capsule was also constructed from four gear-shaped amphiphiles ...
  10. A synthetic approach to a molecular crank mechanism: toward intramolecular motion transformation between rotation and translation.

    Dalton Transactions (Print Edition) 39(17):4107 (2010) PMID 20390173

    A molecular crank mechanism that enables transformation between rotational and translational motions was designed and synthesized. This molecule consists of a molecular ball bearing as the rotational part in which two disk-shaped rotors can rotate relative to each other through ligand exchange a...
  11. CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.

    Arteriosclerosis, Thrombosis, and Vascular Biology 30(4):675 (2010) PMID 20139355

    CCN3 belongs to the CCN family, which constitutes multifunctional secreted proteins that act as matrix cellular regulators. We investigated the pathophysiological roles of CCN3 in the vessels. We examined the effects of CCN3 on the proliferation and migration of rat vascular smooth muscle cells ...
  12. Site-selective ligand exchange on a heteroleptic Ti(IV) complex towards stepwise multicomponent self-assembly.

    Chemistry: A European Journal 16(11):3318 (2010) PMID 20187047

    A series of heteroleptic [Ti1(2)X](-) complexes have been selectively constructed from a mixture of Ti(IV) ions, a pyridyl catechol ligand (H(2)1; H(2)1=4-(3-pyridyl)catechol), and various bidentate ligands (HX) in the presence of a weak base, in addition to a previously reported [Ti1(2)(acac)](...
  13. The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex.

    European Neuropsychopharmacology 20(3):176 (2010) PMID 19836928

    Using the RNA arbitrarily-primed PCR and the competitive RT-PCR, we have isolated the neocortical transcripts that are upregulated and unchanged in the adult and infant rats, respectively, after a systemic injection of an N-methyl-d-aspartate (NMDA) receptor antagonist phencyclidine (PCP), and f...
  14. A molecular double ball bearing: an Ag(I)-Pt(II) dodecanuclear quadruple-decker complex with three rotors.

    Angewandte Chemie. International edition in Eng... 49(9):1669 (2010) PMID 20120001

  15. Site-selective internal cross-linking between mercury(II)-centered vertices of an octahedral mercury(II) capsule by a rod-shaped ditopic ligand.

    Angewandte Chemie. International edition in Eng... 49(1):138 (2010) PMID 19943313

  16. Template-directed synthesis of a covalent organic capsule based on a 3 nm-sized metallocapsule.

    Journal of the American Chemical Society 131(33):11646 (2009) PMID 19645469

    A 4 nm-sized covalent organic capsule having 24 pyridyl groups was synthesized in extremely high yield (43% in three steps) using an octahedron-shaped metallocapsule as a template molecule. The entity was fully characterized by NMR and MALDI-TOF MS measurements. N-Methylation of the 24 pyridyl g...
  17. Alternate arrangements of two different metals at chemically-equivalent binding sites on a circle.

    Journal of the American Chemical Society 131(13):4592 (2009) PMID 19296580

    Two different metal ions, monovalent M(+) (M = Ag, Cu) and divalent Hg(2+), were alternately arranged on a circle with a diameter of 1.5 nm in such a way that six metal ions were put between two disk-shaped hexamonodentate template ligands (L), thereby forming the sandwich-shaped hexanuclear com...
  18. FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.

    Nature Genetics 41(3):289 (2009) PMID 19219044 PMCID PMC2676118

    The spontaneous dominant mouse mutant, Elbow knee synostosis (Eks), shows elbow and knee joint synosotsis, and premature fusion of cranial sutures. Here we identify a missense mutation in the Fgf9 gene that is responsible for the Eks mutation. Through investigation of the pathogenic mechanisms o...
  19. T1783Kif26a-Deficient Mice Develop Megacolon Associated with Dysfunction of Enteric Neuronal Cells in the Colon

    Gastroenterology 136(5):A (2009)

  20. Induced-fit formation of a tetrameric organic capsule consisting of hexagram-shaped amphiphile molecules.

    Angewandte Chemie. International edition in Eng... 48(38):7006 (2009) PMID 19701954