1. Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.

    Experimental Animals 64(2):121 (2015) PMID 25736479 PMCID PMC4427726

    Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfis...
  2. Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats

    Archives of Oral Biology 59(12):1368 (2014)

    • TMJ hypofunction leads to OA-like changes under mechanical loading. • Masticatory stimulation in growing period is essential for normal TMJ development. ...
  3. Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats.

    Archives of Oral Biology 59(12):1368 (2014) PMID 25201702

    Temporomandibular joint (TMJ) hypofunction secondary to feeding a liquid diet in the growing period leads to morphological hypoplasia. However, few studies have evaluated the results of mechanical loading on the hypoplastic TMJ. This study investigated whether TMJ hypofunction in rats causes ost...
  4. Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats.

    Archives of Oral Biology 59(12):1368 (2014) PMID 25201702

    Temporomandibular joint (TMJ) hypofunction secondary to feeding a liquid diet in the growing period leads to morphological hypoplasia. However, few studies have evaluated the results of mechanical loading on the hypoplastic TMJ. This study investigated whether TMJ hypofunction in rats causes ost...
  5. Distribution of matrix proteins in perichondrium and periosteum during the incorporation of Meckel's cartilage into ossifying mandible in midterm human fetuses: an immunohistochemical study.

    Anatomical Record. Part A: Advances in Integrat... 297(7):1208 (2014) PMID 24700703

    Immunohistochemical localization of versican and tenascin-C were performed; the periosteum of ossifying mandible and the perichondrium of Meckel's cartilage, of vertebral cartilage, and of mandibular condylar cartilage were examined in midterm human fetuses. Versican immunoreactivity was restric...
  6. Distribution of matrix proteins in perichondrium and periosteum during the incorporation of Meckel's cartilage into ossifying mandible in midterm human fetuses: an immunohistochemical study.

    Anatomical Record. Part A: Advances in Integrat... 297(7):1208 (2014) PMID 24700703

    Immunohistochemical localization of versican and tenascin-C were performed; the periosteum of ossifying mandible and the perichondrium of Meckel's cartilage, of vertebral cartilage, and of mandibular condylar cartilage were examined in midterm human fetuses. Versican immunoreactivity was restric...
  7. Distribution of matrix proteins in perichondrium and periosteum during the incorporation of Meckel's cartilage into ossifying mandible in midterm human fetuses: an immunohistochemical study.

    Anatomical Record. Part A: Advances in Integrat... 297(7):1208 (2014) PMID 24700703

    Immunohistochemical localization of versican and tenascin-C were performed; the periosteum of ossifying mandible and the perichondrium of Meckel's cartilage, of vertebral cartilage, and of mandibular condylar cartilage were examined in midterm human fetuses. Versican immunoreactivity was restric...
  8. Expression of carbonic anhydrase IX in human fetal joints, ligaments and tendons: a potential marker of mechanical stress in fetal development?

    Anatomy & Cell Biology 46(4):272 (2013) PMID 24386600 PMCID PMC3875845

    Carbonic anhydrase type IX (CA9) is known to express in the fetal joint cartilage to maintain pH against hypoxia. Using paraffin-embedded histology of 10 human fetuses at 10-16 weeks of gestation with an aid of immunohistochemistry of the intermediate filaments, matrix components (collagen types...
  9. Expression of carbonic anhydrase IX in human fetal joints, ligaments and tendons: a potential marker of mechanical stress in fetal development?

    Anatomy & Cell Biology 46(4):272 (2013) PMID 24386600 PMCID PMC3875845

    Carbonic anhydrase type IX (CA9) is known to express in the fetal joint cartilage to maintain pH against hypoxia. Using paraffin-embedded histology of 10 human fetuses at 10-16 weeks of gestation with an aid of immunohistochemistry of the intermediate filaments, matrix components (collagen types...
  10. Coexistence of Elastic Fibers with Hyaluronic Acid in the Human Urethral Sphincter Complex: A Histological Study

    The Journal of Urology 190(4):1313 (2013)

    Purpose To promote the prevention and treatment of urethral sphincteric dysfunction, we examined the distribution of elastic fibers around the urethral sphincter complex and the histological localization of hyaluronic acid in relation to elastic fiber architecture.
  11. Coexistence of elastic fibers with hyaluronic acid in the human urethral sphincter complex: a histological study.

    The Journal of Urology 190(4):1313 (2013) PMID 23583858

    To promote the prevention and treatment of urethral sphincteric dysfunction, we examined the distribution of elastic fibers around the urethral sphincter complex and the histological localization of hyaluronic acid in relation to elastic fiber architecture. Using elastica-Masson staining as well...
  12. Expression of hyaluronan (hyaluronic acid) in the developing laminar architecture of the human fetal brain

    Annals of Anatomy - Anatomischer Anzeiger 195(5):424 (2013)

    Hyaluronan (also called hyaluronic acid or HA) plays a key role in the morphogenesis of the brain, but little is known about its expression in the human fetal neocortex. Using immunohistochemical methods, we assayed the expression of HA, glial fibrillary acidic protein, vimentin, nesti...
  13. Coexistence of Elastic Fibers with Hyaluronic Acid in the Human Urethral Sphincter Complex: A Histological Study

    The Journal of Urology 190(4):1313 (2013) PMID 23583858

    Purpose To promote the prevention and treatment of urethral sphincteric dysfunction, we examined the distribution of elastic fibers around the urethral sphincter complex and the histological localization of hyaluronic acid in relation to elastic fiber architecture.
  14. Fetal development of the elastic-fiber-mediated enthesis in the human middle ear

    Annals of Anatomy - Anatomischer Anzeiger 195(5):441 (2013)

    In the human middle ear, the annular ligament of the incudostapedial joint and the insertions of the tensor tympani and stapedius muscles contain abundant elastic fibers; i.e., the elastic-fiber-mediated entheses. Hyaluronan also coexists with the elastic fibers. In the present study u...
  15. Expression of hyaluronan (hyaluronic acid) in the developing laminar architecture of the human fetal brain.

    Annals of Anatomy - Anatomischer Anzeiger 195(5):424 (2013) PMID 23981810

    Hyaluronan (also called hyaluronic acid or HA) plays a key role in the morphogenesis of the brain, but little is known about its expression in the human fetal neocortex. Using immunohistochemical methods, we assayed the expression of HA, glial fibrillary acidic protein, vimentin, nestin, and pro...
  16. Fetal development of the elastic-fiber-mediated enthesis in the human middle ear.

    Annals of Anatomy - Anatomischer Anzeiger 195(5):441 (2013) PMID 23706648

    In the human middle ear, the annular ligament of the incudostapedial joint and the insertions of the tensor tympani and stapedius muscles contain abundant elastic fibers; i.e., the elastic-fiber-mediated entheses. Hyaluronan also coexists with the elastic fibers. In the present study using immun...
  17. Expression of hyaluronan (hyaluronic acid) in the developing laminar architecture of the human fetal brain.

    Annals of Anatomy - Anatomischer Anzeiger 195(5):424 (2013) PMID 23981810

    Hyaluronan (also called hyaluronic acid or HA) plays a key role in the morphogenesis of the brain, but little is known about its expression in the human fetal neocortex. Using immunohistochemical methods, we assayed the expression of HA, glial fibrillary acidic protein, vimentin, nestin, and pro...
  18. Fetal development of the elastic-fiber-mediated enthesis in the human middle ear.

    Annals of Anatomy - Anatomischer Anzeiger 195(5):441 (2013) PMID 23706648

    In the human middle ear, the annular ligament of the incudostapedial joint and the insertions of the tensor tympani and stapedius muscles contain abundant elastic fibers; i.e., the elastic-fiber-mediated entheses. Hyaluronan also coexists with the elastic fibers. In the present study using immun...
  19. Dense distribution of macrophages in flexor aspects of the hand and foot of mid-term human fetuses.

    Anatomy & Cell Biology 45(4):259 (2012) PMID 23301193 PMCID PMC3531589

    In the developing human musculoskeletal system, cell death with macrophage accumulation occurs in the thigh muscle and interdigital area. To comprehensively clarify the distribution of macrophages, we immunohistochemically examined 16 pairs of upper and lower extremities without the hip joint (l...
  20. Dense distribution of macrophages in flexor aspects of the hand and foot of mid-term human fetuses.

    Anatomy & Cell Biology 45(4):259 (2012) PMID 23301193 PMCID PMC3531589

    In the developing human musculoskeletal system, cell death with macrophage accumulation occurs in the thigh muscle and interdigital area. To comprehensively clarify the distribution of macrophages, we immunohistochemically examined 16 pairs of upper and lower extremities without the hip joint (l...