1. Liver is liver and blood is blood, and finally the twain have met.

    Journal of Hepatology 65(2):245 (2016) PMID 27221221

  2. Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation.

    Blood 128(2):297 (2016) PMID 27247137 PMCID PMC4946205

    The ability of cord blood transplantation (CBT) to prevent relapse depends partly on donor natural killer (NK) cell alloreactivity. NK effector function depends on specific killer-cell immunoglobulin-like receptors (KIR) and HLA interactions. Thus, it is important to identify optimal combination...
  3. Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.

    Stem Cells and Development 25(10):774 (2016) PMID 26979751 PMCID PMC4870609

    The remarkable functional plasticity of professional antigen-presenting cells (APCs) allows the adaptive immune system to respond specifically to an incredibly diverse array of potential pathogenic insults; nonetheless, the specific molecular effectors and mechanisms that underpin this plasticit...
  4. Daring to learn from humanized mice.

    Blood 125(25):3829 (2015) PMID 26089378

  5. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.

    Nature 510(7503):157 (2014) PMID 24759321 PMCID PMC4127885

    The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbours specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17-producing γδ T (γδT17) cells, the aberrant ac...
  6. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12.

    Immunology 140(1):98 (2013) PMID 23659714 PMCID PMC3809710

    Natural killer (NK) cell-mediated contact sensitivity was recently described in mice. Here, we confirm NK cell-mediated contact sensitivity (CS) in SCID and RAG1(-/-) mice but not in SCIDbeige mice, which have non-functional NK cells that lack NK cell granules. NK cell-mediated CS was transferre...
  7. Natural killer cell memory.

    Nature Immunology 12(6):500 (2011) PMID 21739673

    Natural killer (NK) cells are bone marrow–derived granular lymphocytes that have a key role in immune defense against viral and bacterial infections and malignancies. NK cells are traditionally defined as cells of the innate immune response because they lack RAG recombinase–dependent clonal anti...
  8. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

    Nature Immunology 11(12):1127 (2010) PMID 20972432 PMCID PMC2982944

    Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular st...
  9. Adaptive immune responses mediated by natural killer cells.

    Immunological Reviews 235(1):286 (2010) PMID 20536570 PMCID PMC2911633

    Adaptive immunity has traditionally been considered a unique feature of vertebrate physiology. Unlike innate immune responses, which remain essentially unchanged upon exposure to a recurrent challenge with the same stimulus, adaptive immune cells possess the ability to learn and remember. Thus, ...
  10. Regulatory T cells and autoimmune disease.

    Immunological Reviews 204:195 (2005) PMID 15790360

    Although T-cell clones bearing T-cell receptors with high affinity for self-peptide major histocompatibility complex (MHC) products are generally eliminated in the thymus (recessive tolerance), the peripheral T-cell repertoire remains strongly biased toward self-peptide MHC complexes and include...
  11. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes.

    Nature Immunology 6(1):65 (2005) PMID 15608642

    Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to...
  12. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.

    PNAS 101(28):10398 (2004) PMID 15235129 PMCID PMC478583

    Although there is considerable evidence that a subpopulation of regulatory CD4(+)CD25+ T cells can suppress the response of autoreactive T cells, the underlying molecular mechanism is not understood. We find that transmission of a suppressive signal by CD4CD25+ regulatory cells requires engageme...