1. The fine-scale genetic structure of the British population.

    Nature 519(7543):309 (2015) PMID 25788095

    Fine-scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype-based statistical methods to analyse genome-wide single nucleotide polymorphism (SNP) data from a c...
  2. Unravelling the hidden ancestry of American admixed populations.

    Nature Communications 6:6596 (2015) PMID 25803618 PMCID PMC4374169

    The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variet...
  3. Hand trauma: A prospective study of its epidemiology, infection rates and functional outcomes with consideration of the role of early hand therapy and prophylactic antibiotics

    International Journal of Surgery 12:S72 (2014)

  4. Hand trauma: A prospective study of its epidemiology, infection rates and functional outcomes with consideration of the role of early hand therapy and prophylactic antibiotics

    International Journal of Surgery 12:S72 (2014)

  5. The use of coleman fat grafting in the OMFS trauma patient

    British Journal of Oral and Maxillofacial Surgery 52(8):e59 (2014)

  6. Nanotechnology biomimetic cartilage regenerative scaffolds.

    Archives of Plastic Surgery 41(3):231 (2014) PMID 24883273 PMCID PMC4037768

    Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechno...
  7. Nanotechnology biomimetic cartilage regenerative scaffolds.

    Archives of Plastic Surgery 41(3):231 (2014) PMID 24883273 PMCID PMC4037768

    Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechno...
  8. A genetic atlas of human admixture history.

    Science 343(6172):747 (2014) PMID 24531965 PMCID PMC4209567

    Modern genetic data combined with appropriate statistical methods have the potential to contribute substantially to our understanding of human history. We have developed an approach that exploits the genomic structure of admixed populations to date and characterize historical mixture events at f...
  9. A genetic atlas of human admixture history.

    Science 343(6172):747 (2014) PMID 24531965 PMCID PMC4209567

    Modern genetic data combined with appropriate statistical methods have the potential to contribute substantially to our understanding of human history. We have developed an approach that exploits the genomic structure of admixed populations to date and characterize historical mixture events at f...
  10. Combination studies of platinum(II)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin.

    Metallomics 6(1):126 (2014) PMID 24084749

    With current chemotherapeutic treatment regimes often limited by adverse side effects, the synergistic combination of complexes with anticancer activity appears to offer a promising strategy for effective cancer treatment. This work investigates the anti-proliferative activity using a combinatio...
  11. Combination studies of platinum(II)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin.

    Metallomics 6(1):126 (2014) PMID 24084749

    With current chemotherapeutic treatment regimes often limited by adverse side effects, the synergistic combination of complexes with anticancer activity appears to offer a promising strategy for effective cancer treatment. This work investigates the anti-proliferative activity using a combinatio...
  12. Latent Transforming Growth Factor-beta1 Functionalised Electrospun Scaffolds Promote Human Cartilage Differentiation: Towards an Engineered Cartilage Construct.

    Archives of Plastic Surgery 40(6):676 (2013) PMID 24286039 PMCID PMC3840173

    To overcome the potential drawbacks of a short half-life and dose-related adverse effects of using active transforming growth factor-beta 1 for cartilage engineering, a cell-mediated latent growth factor activation strategy was developed incorporating latent transforming growth factor-β1 (LTGF) ...
  13. Latent Transforming Growth Factor-beta1 Functionalised Electrospun Scaffolds Promote Human Cartilage Differentiation: Towards an Engineered Cartilage Construct.

    Archives of Plastic Surgery 40(6):676 (2013) PMID 24286039 PMCID PMC3840173

    To overcome the potential drawbacks of a short half-life and dose-related adverse effects of using active transforming growth factor-beta 1 for cartilage engineering, a cell-mediated latent growth factor activation strategy was developed incorporating latent transforming growth factor-β1 (LTGF) ...
  14. The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells.

    Metallomics 5(8):1061 (2013) PMID 23784536

    56MESS has been shown to be cytotoxic but the mode of this action is unclear. In order to probe the mechanism of action for 56MESS, MDCK cells were utilised to investigate the effect on treated cells. IC50 values for 56MESS and cisplatin in the MDCK cell line, determined by a SRB assay, were 0.2...
  15. The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells.

    Metallomics 5(8):1061 (2013) PMID 23784536

    56MESS has been shown to be cytotoxic but the mode of this action is unclear. In order to probe the mechanism of action for 56MESS, MDCK cells were utilised to investigate the effect on treated cells. IC50 values for 56MESS and cisplatin in the MDCK cell line, determined by a SRB assay, were 0.2...
  16. Great ape genetic diversity and population history.

    Nature 499(7459):471 (2013) PMID 23823723 PMCID PMC3822165

    Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape...
  17. Great ape genetic diversity and population history.

    Nature 499(7459):471 (2013) PMID 23823723 PMCID PMC3822165

    Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape...
  18. Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane.

    Dalton Transactions (Print Edition) 42(4):918 (2013) PMID 23018340

    Twelve metallointercalators of the type [Pt(I(L))(A(L))](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and I(L) is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-ph...
  19. Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane.

    Dalton Transactions (Print Edition) 42(4):918 (2013) PMID 23018340

    Twelve metallointercalators of the type [Pt(I(L))(A(L))](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and I(L) is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-ph...
  20. Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane.

    Dalton Transactions (Print Edition) 42(4):918 (2013) PMID 23018340

    Twelve metallointercalators of the type [Pt(I(L))(A(L))](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and I(L) is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-ph...