1. Rapid genotype imputation from sequence without reference panels.

    Nature Genetics 48(8):965 (2016) PMID 27376236 PMCID PMC4966640

    Inexpensive genotyping methods are essential for genetic studies requiring large sample sizes. In human studies, array-based microarrays and high-density haplotype reference panels allow efficient genotype imputation for this purpose. However, these resources are typically unavailable in non-hum...
  2. Anastomosis Lapse Index (ALI): A Validated End Product Assessment Tool for Simulation Microsurgery Training.

    Journal of Reconstructive Microsurgery 32(3):233 (2016) PMID 26645156

    Over the last decade, simulation has become a principal training method in microsurgery. With an increasing move toward the use of nonliving models, there is a need to develop methods for assessment of microvascular anastomosis skill acquisition substituting traditional patency rate. The authors...
  3. The Kalash Genetic Isolate? The Evidence for Recent Admixture.

    The American Journal of Human Genetics 98(2):396 (2016) PMID 26849116 PMCID PMC4746362

  4. Free-Tissue Transfer for the Reconstruction of War-Related Extremity Injuries: A Systematic Review of Current Practice.

    Military Medicine 181(1):27 (2016) PMID 26741474

    Extremity injuries in combat zones have devastating sequelae. The increasing survival of war-zone casualties, combined with rapid advances in microsurgery, means that there is a growing role for free-tissue reconstruction. We systematically reviewed the current practices in microsurgical reconst...
  5. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

    Current Biology 25(21):2878 (2015)

  6. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.

    Current Biology 25(19):2518 (2015) PMID 26387712 PMCID PMC4714572

    Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-...
  7. Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference.

    PLoS Genetics 11(8):e1005397 (2015) PMID 26291793 PMCID PMC4546361

    The Ari peoples of Ethiopia are comprised of different occupational groups that can be distinguished genetically, with Ari Cultivators and the socially marginalised Ari Blacksmiths recently shown to have a similar level of genetic differentiation between them (FST ≈ 0.023 - 0.04) as that observe...
  8. The fine-scale genetic structure of the British population.

    Nature 519(7543):309 (2015) PMID 25788095 PMCID PMC4632200

    Fine-scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype-based statistical methods to analyse genome-wide single nucleotide polymorphism (SNP) data from a c...
  9. Unravelling the hidden ancestry of American admixed populations.

    Nature Communications 6:6596 (2015) PMID 25803618 PMCID PMC4374169

    The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variet...
  10. Hand trauma: A prospective study of its epidemiology, infection rates and functional outcomes with consideration of the role of early hand therapy and prophylactic antibiotics

    International Journal of Surgery 12:S72 (2014)

  11. The use of coleman fat grafting in the OMFS trauma patient

    British Journal of Oral and Maxillofacial Surgery 52(8):e59 (2014)

  12. Nanotechnology biomimetic cartilage regenerative scaffolds.

    Archives of Plastic Surgery 41(3):231 (2014) PMID 24883273 PMCID PMC4037768

    Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechno...
  13. A genetic atlas of human admixture history.

    Science 343(6172):747 (2014) PMID 24531965 PMCID PMC4209567

    Modern genetic data combined with appropriate statistical methods have the potential to contribute substantially to our understanding of human history. We have developed an approach that exploits the genomic structure of admixed populations to date and characterize historical mixture events at f...
  14. Combination studies of platinum(II)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin.

    Metallomics 6(1):126 (2014) PMID 24084749

    With current chemotherapeutic treatment regimes often limited by adverse side effects, the synergistic combination of complexes with anticancer activity appears to offer a promising strategy for effective cancer treatment. This work investigates the anti-proliferative activity using a combinatio...
  15. Latent Transforming Growth Factor-beta1 Functionalised Electrospun Scaffolds Promote Human Cartilage Differentiation: Towards an Engineered Cartilage Construct.

    Archives of Plastic Surgery 40(6):676 (2013) PMID 24286039 PMCID PMC3840173

    To overcome the potential drawbacks of a short half-life and dose-related adverse effects of using active transforming growth factor-beta 1 for cartilage engineering, a cell-mediated latent growth factor activation strategy was developed incorporating latent transforming growth factor-β1 (LTGF) ...
  16. The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells.

    Metallomics 5(8):1061 (2013) PMID 23784536

    56MESS has been shown to be cytotoxic but the mode of this action is unclear. In order to probe the mechanism of action for 56MESS, MDCK cells were utilised to investigate the effect on treated cells. IC50 values for 56MESS and cisplatin in the MDCK cell line, determined by a SRB assay, were 0.2...
  17. Great ape genetic diversity and population history.

    Nature 499(7459):471 (2013) PMID 23823723 PMCID PMC3822165

    Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape...
  18. Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane.

    Dalton Transactions (Print Edition) 42(4):918 (2013) PMID 23018340

    Twelve metallointercalators of the type [Pt(I(L))(A(L))](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and I(L) is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-ph...
  19. Trauma’12 Winning Abstract – End Product Assessment in Microsurgery Simulation Training – A New Insider View

    Annals of Medicine and Surgery 2(1):36 (2013)

    Background There are various assessment methods that allow the evaluation of skills acquisition in microsurgery simulation training such as global rating scores and check lists. The present scoring systems are used to analyse the process of conducting an anastomosis. This pap...
  20. Bayesian refinement of association signals for 14 loci in 3 common diseases.

    Nature Genetics 44(12):1294 (2012) PMID 23104008 PMCID PMC3791416

    To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes t...