1. Development of Connectivity in a Motoneuronal Network in Drosophila Larvae

    Current Biology 25(5):568 (2015) PMID 25702582 PMCID PMC4353686

    Background Much of our understanding of how neural networks develop is based on studies of sensory systems, revealing often highly stereotyped patterns of connections, particularly as these diverge from the presynaptic terminals of sensory neurons. We know considerably less a...
  2. Development of connectivity in a motoneuronal network in Drosophila larvae.

    Current Biology 25(5):568 (2015) PMID 25702582

    Much of our understanding of how neural networks develop is based on studies of sensory systems, revealing often highly stereotyped patterns of connections, particularly as these diverge from the presynaptic terminals of sensory neurons. We know considerably less about the wiring strategies of m...
  3. Development of connectivity in a motoneuronal network in Drosophila larvae

    Current Biology (2014)

    Background: Much of our understanding of how neural networks develop is based on studies of sensory systems, revealing often highly stereotyped patterns of connections, particularly as these diverge from the presynaptic terminals of sensory neurons. We know considerably less about the ...
  4. An epigenetic way to forget those painful moments

    Trends in Neurosciences (2014)

    Traumatic experience can be overwhelming, thus erasing associated memories is desirable. While exposure-based and reconsolidation methods have been developed for recently acquired associations, treatments to modify more distant memories are rare. Focusing on HDAC2 inhibition during rec...
  5. An epigenetic way to forget those painful moments

    Trends in Neurosciences (2014)

    Traumatic experience can be overwhelming, thus erasing associated memories is desirable. While exposure-based and reconsolidation methods have been developed for recently acquired associations, treatments to modify more distant memories are rare. Focusing on HDAC2 inhibition during rec...
  6. An epigenetic way to forget those painful moments

    Trends in Neurosciences (2014)

    Traumatic experience can be overwhelming, thus erasing associated memories is desirable. While exposure-based and reconsolidation methods have been developed for recently acquired associations, treatments to modify more distant memories are rare. Focusing on HDAC2 inhibition during rec...
  7. Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.

    PLoS Genetics 9(4):e1003452 (2013) PMID 23637622 PMCID PMC3630106

    Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neur...
  8. Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.

    PLoS Genetics 9(4):e1003452 (2013) PMID 23637622 PMCID PMC3630106

    Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neur...
  9. Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe.

    PLoS Biology 10(10):e1001400 (2012) PMID 23055825 PMCID PMC3462790

    Olfactory neuropiles across different phyla organize into glomerular structures where afferents from a single olfactory receptor class synapse with uniglomerular projecting interneurons. In adult Drosophila, olfactory projection interneurons, partially instructed by the larval olfactory system l...
  10. Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe.

    PLoS Biology 10(10):e1001400 (2012) PMID 23055825 PMCID PMC3462790

    Olfactory neuropiles across different phyla organize into glomerular structures where afferents from a single olfactory receptor class synapse with uniglomerular projecting interneurons. In adult Drosophila, olfactory projection interneurons, partially instructed by the larval olfactory system l...
  11. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster.

    Genetics 178(4):1895 (2008) PMID 18430923 PMCID PMC2323784

    The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis that these mechanisms are singular, we examined the learning phenotypes of 10 new strains. Five of...
  12. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster.

    Genetics 178(4):1895 (2008) PMID 18430923 PMCID PMC2323784

    The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis that these mechanisms are singular, we examined the learning phenotypes of 10 new strains. Five of...
  13. Gateway cloning vectors for the LexA-based binary expression system in Drosophila.

    Fly 2(4):236 (2008) PMID 18776741 PMCID PMC2913122

    Studies on the formation of connections in the developing nervous system are greatly aided by methods that permit the differential visualisation and manipulation of pre- and postsynaptic partner neurons. This has been facilitated by the advent of the LexA-based, GAL4/UAS-independent, binary expr...
  14. Genetic dissociation of acquisition and memory strength in the heat-box spatial learning paradigm in Drosophila.

    Learning & Memory 13(1):72 (2006) PMID 16418434 PMCID PMC1360135

    Memories can have different strengths, largely dependent on the intensity of reinforcers encountered. The relationship between reinforcement and memory strength is evident in asymptotic memory curves, with the level of the asymptote related to the intensity of the reinforcer. Although this is li...
  15. An epigenetic way to forget those painful moments

    Trends in Neurosciences (1986)

    Traumatic experience can be overwhelming, thus erasing associated memories is desirable. While exposure-based and reconsolidation methods have been developed for recently acquired associations, treatments to modify more distant memories are rare. Focusing on HDAC2 inhibition during rec...