1. Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness.

    PNAS 112(25):7839 (2015) PMID 26056284 PMCID PMC4485103

    In unconscious status (e.g., deep sleep and anesthetic unconsciousness) where cognitive functions are not generated there is still a significant level of brain activity present. Indeed, the electrophysiology of the unconscious brain is characterized by well-defined thalamocortical rhythmicity. H...
  2. Enhanced synaptic transmission at the squid giant synapse by artificial seawater based on physically modified saline.

    Frontiers in Synaptic Neuroscience 6:2 (2014) PMID 24575037 PMCID PMC3921564

    Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission. This was determined by examining the postsynaptic response to single and repetitive presynaptic spike activa...
  3. Enhanced synaptic transmission at the squid giant synapse by artificial seawater based on physically modified saline.

    Frontiers in Synaptic Neuroscience 6:2 (2014) PMID 24575037 PMCID PMC3921564

    Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission. This was determined by examining the postsynaptic response to single and repetitive presynaptic spike activa...
  4. Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA.

    Frontiers in Synaptic Neuroscience 3:3 (2011) PMID 21629767 PMCID PMC3099362

    Filamentous tau inclusions are hallmarks of Alzheimer's disease and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau-mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. We have evaluated the effects of human ta...
  5. Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA.

    Frontiers in Synaptic Neuroscience 3:3 (2011) PMID 21629767 PMCID PMC3099362

    Filamentous tau inclusions are hallmarks of Alzheimer's disease and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau-mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. We have evaluated the effects of human ta...
  6. Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.

    Journal of Physiology 588(Pt 16):3031 (2010) PMID 20547676 PMCID PMC2956943

    The role of P/Q- and T-type calcium channels in the rhythmic oscillatory behaviour of inferior olive (IO) neurons was investigated in mutant mice. Mice lacking either the CaV2.1 gene of the pore-forming alpha1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-forming alpha1G ...
  7. Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.

    Journal of Physiology 588(Pt 16):3031 (2010) PMID 20547676 PMCID PMC2956943

    The role of P/Q- and T-type calcium channels in the rhythmic oscillatory behaviour of inferior olive (IO) neurons was investigated in mutant mice. Mice lacking either the CaV2.1 gene of the pore-forming alpha1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-forming alpha1G ...
  8. Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive.

    PNAS 107(23):10731 (2010) PMID 20498062 PMCID PMC2890811

    The rhythmic motor pathway activation by pacemaker neurons or circuits in the brain has been proposed as the mechanism for the timing of motor coordination, and the abnormal potentiation of this mechanism may lead to a pathological tremor. Here, we show that the potentiation of Ca(V)3.1 T-type C...
  9. Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive.

    PNAS 107(23):10731 (2010) PMID 20498062 PMCID PMC2890811

    The rhythmic motor pathway activation by pacemaker neurons or circuits in the brain has been proposed as the mechanism for the timing of motor coordination, and the abnormal potentiation of this mechanism may lead to a pathological tremor. Here, we show that the potentiation of Ca(V)3.1 T-type C...
  10. Role of Rab27 in synaptic transmission at the squid giant synapse.

    PNAS 105(41):16003 (2008) PMID 18840683 PMCID PMC2562534

    Small GTPase Rab is a member of a large family of Ras-related proteins, highly conserved in eukaryotic cells, and thought to regulate specific type(s) and/or specific step(s) in intracellular membrane trafficking. Given our interest in synaptic transmission, we addressed the possibility that Rab...
  11. Role of Rab27 in synaptic transmission at the squid giant synapse.

    PNAS 105(41):16003 (2008) PMID 18840683 PMCID PMC2562534

    Small GTPase Rab is a member of a large family of Ras-related proteins, highly conserved in eukaryotic cells, and thought to regulate specific type(s) and/or specific step(s) in intracellular membrane trafficking. Given our interest in synaptic transmission, we addressed the possibility that Rab...
  12. Attenuated neuropathic pain in Cav3.1 null mice.

    Molecules and Cells 25(2):242 (2008) PMID 18414012

    To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (alpha1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increas...
  13. Attenuated neuropathic pain in Cav3.1 null mice.

    Molecules and Cells 25(2):242 (2008) PMID 18414012

    To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (alpha1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increas...
  14. T-type Ca2+channels as therapeutic targets in the nervous system

    Current Opinion in Pharmacology 8(1):33 (2008) PMID 18203662

    Low-voltage-activated calcium channels, also known as T-type calcium channels, are widely expressed in various types of neurons. In contrast to high-voltage-activated calcium channels which can be activated by a strong depolarization of membrane potential, T-type channels can be activated b...
  15. T-type Ca2+channels as therapeutic targets in the nervous system

    Current Opinion in Pharmacology 8(1):33 (2008) PMID 18203662

    Low-voltage-activated calcium channels, also known as T-type calcium channels, are widely expressed in various types of neurons. In contrast to high-voltage-activated calcium channels which can be activated by a strong depolarization of membrane potential, T-type channels can be activated b...
  16. T-type Ca2+channels as therapeutic targets in the nervous system

    Current Opinion in Pharmacology 8(1):33 (2008) PMID 18203662

    Low-voltage-activated calcium channels, also known as T-type calcium channels, are widely expressed in various types of neurons. In contrast to high-voltage-activated calcium channels which can be activated by a strong depolarization of membrane potential, T-type channels can be activated b...
  17. T-type Ca2+channels as therapeutic targets in the nervous system

    Current Opinion in Pharmacology 8(1):33 (2008) PMID 18203662

    Low-voltage-activated calcium channels, also known as T-type calcium channels, are widely expressed in various types of neurons. In contrast to high-voltage-activated calcium channels which can be activated by a strong depolarization of membrane potential, T-type channels can be activated b...
  18. Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice.

    PNAS 104(45):17819 (2007) PMID 17968008 PMCID PMC2077027

    Thalamocortical in vivo and in vitro function was studied in mice lacking P/Q-type calcium channels (Cav2.1), in which N-type calcium channels (Cav2.2) supported central synaptic transmission. Unexpectedly, in vitro patch recordings from thalamic neurons demonstrated no gamma-band subthreshold o...
  19. Chapter 14 Functional Diversity of Voltage‐Dependent Ca2+Channels in Nociception: Recent Progress in Genetic Studies

    Current Topics in Membranes 57:415 (2006)

    This chapter reviews the behavioral consequences in mice lacking diverse subunits of voltage‐dependent Ca2+ channels (VDCCs) in response to various types of painful stimuli and compares these phenotypes with the data obtained from pharmacology‐based approaches. These collective studies...
  20. Chapter 14 Functional Diversity of Voltage‐Dependent Ca2+Channels in Nociception: Recent Progress in Genetic Studies

    Current Topics in Membranes 57:415 (2006)

    This chapter reviews the behavioral consequences in mice lacking diverse subunits of voltage‐dependent Ca2+ channels (VDCCs) in response to various types of painful stimuli and compares these phenotypes with the data obtained from pharmacology‐based approaches. These collective studies...