1. Sleep Stage Coordination of Respiration and Swallowing: A Preliminary Study.

    Dysphagia 31(4):579 (2016) PMID 27338262

    Swallowing is an important physiological response that protects the airway. Although aspiration during sleep may cause aspiration pneumonia, the mechanisms responsible have not yet been elucidated. We evaluated the coordination between respiration and swallowing by infusing water into the pharyn...
  2. Endoscopy evaluation to predict oral appliance outcomes in obstructive sleep apnoea.

    European Respiratory Journal 47(5):1410 (2016) PMID 26743482

    The objective of this study was to determine the utility of nasoendoscopy of the upper airway as a predictor of the efficacy of oral appliance treatment in obstructive sleep apnoea (OSA).A total of 61 consecutive patients with moderate-to-severe polysomnographically diagnosed OSA were recruited ...
  3. Cryptochrome-dependent circadian periods in the arcuate nucleus.

    Neuroscience Letters 610:123 (2016) PMID 26542738

    The circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus is responsible for controlling behavioral activity rhythms, such as a free running rhythm in constant darkness. Rodents have several circadian oscillators in other brain regions including the arcuate nucleus (ARC). ...
  4. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland.

    Developmental Dynamics 244(3):488 (2015) PMID 25410786

    The rodent salivary gland is not fully developed at birth and the cellular definitive differentiation takes place postnatally. However, little is known about its molecular mechanism. Here we provide the loss-of-function genetic evidence that Runx signaling affects postnatal development of the su...
  5. Erratum to: Videoendoscopic diagnosis for predicting the response to oral appliance therapy in severe obstructive sleep apnea.

    Sleep and Breathing 19(1):419 (2015) PMID 24906543

  6. Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells.

    BioMed Research International 2015:293570 (2015) PMID 26185754 PMCID PMC4491559

    This report describes our initial attempt to regenerate salivary glands using induced pluripotent stem (iPS) cells in vivo and in vitro. Glandular tissues that were similar to the adult submandibular glands (SMGs) and sublingual glands could be partially produced by the transplantation of iPS ce...
  7. Melatonin inhibits embryonic salivary gland branching morphogenesis by regulating both epithelial cell adhesion and morphology.

    PLoS ONE 10(4):e0119960 (2015) PMID 25876057 PMCID PMC4398443

    Many organs, including salivary glands, lung, and kidney, are formed by epithelial branching during embryonic development. Branching morphogenesis occurs via either local outgrowths or the formation of clefts that subdivide epithelia into buds. This process is promoted by various factors, but th...
  8. Peptide-modified Substrate for Modulating Gland Tissue Growth and Morphology In Vitro.

    Scientific reports 5:11468 (2015) PMID 26098225 PMCID PMC4476418

    In vitro fabricated biological tissue would be a valuable tool to screen newly synthesized drugs or understand the tissue development process. Several studies have attempted to fabricate biological tissue in vitro. However, controlling the growth and morphology of the fabricated tissue remains a...
  9. Videoendoscopic diagnosis for predicting the response to oral appliance therapy in severe obstructive sleep apnea.

    Sleep and Breathing 18(4):809 (2014) PMID 24532144

    In treatment for obstructive sleep apnea (OSA), oral appliance (OA) therapy is indicated in patients with mild-moderate OSA. However, since patients with severe OSA in whom OA therapy was effective have also been reported, it may not be possible to determine indications for OA therapy based on t...
  10. The efficacy of a lingual augmentation prosthesis for swallowing after a glossectomy: A clinical report

    The Journal of Prosthetic Dentistry 111(4):342 (2014) PMID 24360011

    The excision of malignant tongue tumors often produces tongue defects that can cause dysphagia. A palatal augmentation prosthesis is frequently used to treat such dysphagia. This report describes a patient who received a palatal augmentation prosthesis after a glossectomy for malignant...
  11. Cell and tissue-autonomous development of the circadian clock in mouse embryos.

    FEBS Letters 588(3):459 (2014) PMID 24374345

    The emergence of the circadian rhythm is a dramatic and physiologically essential event for mammals to adapt to daily environmental cycles. It has been demonstrated that circadian rhythms develop during the embryonic stage even when the maternal central pacemaker suprachiasmatic nucleus has been...
  12. Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation.

    PLoS ONE 8(4):e61653 (2013) PMID 23613893 PMCID PMC3629100

    Cleft palate results from a mixture of genetic and environmental factors and occurs when the bilateral palatal shelves fail to fuse. The objective of this study was to search for new genes involved in mouse palate formation. Gene expression of murine embryonic palatal tissue was analyzed at vari...
  13. Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis.

    Biomaterials 32(28):6754 (2011) PMID 21683999

    The mechanical properties of the cellular microenvironment dramatically alter during tissue development and growth. Growing evidence suggests that physical microenvironments and mechanical stresses direct cell fate in developing tissue. However, how these physical cues affect the tissue morphoge...
  14. Btbd7 regulates epithelial cell dynamics and branching morphogenesis.

    Science 329(5991):562 (2010) PMID 20671187 PMCID PMC3412157

    During embryonic development, many organs form by extensive branching of epithelia through the formation of clefts and buds. In cleft formation, buds are delineated by the conversion of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft formation are not clear. ...
  15. Epithelial branching morphogenesis of salivary gland: exploration of new functional regulators.

    The Journal of Medical Investigation 56 Suppl:234 (2009) PMID 20224187

    Many organs such as the salivary glands, kidney and lung form multiple epithelial clefts during the process of branching morphogenesis in embryonic development. The salivary gland provides an excellent model for clarifying the mechanism of this phenomenon. Extracellular matrix molecules regulate...
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  16. Embryonic organ culture.

    Current protocols in cell biology / editorial b... Chapter 19:Unit 19.8 (2008) PMID 19085985

    This unit provides detailed protocols for dissecting embryonic organs and performing organ culture to study questions in developmental biology. Procedures are described here for dissecting organs such as kidney, lung, and salivary gland. The unit also contains commentary including troubleshootin...
  17. Cleftin: A novel fibronectin-induced gene that promotes branching morphogenesis

    Developmental Biology 319(2):505 (2008)

  18. Power spectra analysis of levator veli palatini muscle electromyogram during velopharyngeal closure for swallowing, speech, and blowing.

    Dysphagia 22(2):135 (2007) PMID 17333429

    The velopharynx closes during swallowing and pneumatic activities. Pneumatic closure, which is acquired, prevents expiratory air from passing into the nasal cavity, whereas during swallowing, velopharyngeal closure is achieved innately, preventing regurgitation into the nasal cavity. These findi...
  19. Morphogenesis of Salivary Gland Epithelia: Exploring the Regeneration Process for Xerostomia Treatment

    Journal of Oral and Maxillofacial Surgery 65(9):40.e7 (2007)

  20. Multiple osseous dysplasia arising from impacted teeth: report of a case associated with odontogenic lesions.

    Journal of Oral Pathology and Medicine 35(7):402 (2006) PMID 16827842

    We report a case of osseous dysplasia (OD) showing extremely rare clinical features. A 37-year-old Japanese woman was referred to our clinic complaining of a left alveolar bony swelling at an impacted canine. Radiographic examinations revealed a mixed radiopaque lesion involving the impacted lef...