1. TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

    PLoS ONE 8(2):e55174 (2013) PMID 23468844 PMCID PMC3585300

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, b...
  2. TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

    PLoS ONE 8(2):e55174 (2013) PMID 23468844 PMCID PMC3585300

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, b...
  3. Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/−mice from the development of atherosclerosis

    Cardiovascular Pathology 21(6):499 (2012)

    Aim MIC-1/GDF15 is a member of the TGF-b superfamily, which is thought to have pleiotropic roles in stress responses, inflammation, tissue injury and repair, energy homeostasis, and malignancy. MIC-1/GDF15 was recently identified as a new biomarker for the development of card...
  4. Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.

    Journal of Cell Science 125(Pt 22):5479 (2012) PMID 22956539 PMCID PMC3561857

    Intracellular chloride channel protein 1 (CLIC1) is a 241 amino acid protein of the glutathione S transferase fold family with redox- and pH-dependent membrane association and chloride ion channel activity. Whilst CLIC proteins are evolutionarily conserved in Metazoa, indicating an important rol...
  5. Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.

    Journal of Cell Science 125(Pt 22):5479 (2012) PMID 22956539 PMCID PMC3561857

    Intracellular chloride channel protein 1 (CLIC1) is a 241 amino acid protein of the glutathione S transferase fold family with redox- and pH-dependent membrane association and chloride ion channel activity. Whilst CLIC proteins are evolutionarily conserved in Metazoa, indicating an important rol...
  6. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.

    PLoS ONE 7(4):e34868 (2012) PMID 22514681 PMCID PMC3325923

    Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in can...
  7. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

    Nephrology Dialysis Transplantation 27(1):70 (2012) PMID 21940482

    Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum mediate anorexia and weight loss in some cancer patients and similarly elevated levels occur in chronic kidney disease (CKD). Serum MIC-1/GDF15 is also elevated in chronic inflammatory diseases and predicts atherosclerotic e...
  8. Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis.

    Cardiovascular Pathology 21(6):499 (2012) PMID 22386250

    MIC-1/GDF15 is a member of the TGF-b superfamily, which is thought to have pleiotropic roles in stress responses, inflammation, tissue injury and repair, energy homeostasis, and malignancy. MIC-1/GDF15 was recently identified as a new biomarker for the development of cardiovascular events and th...
  9. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

    PLoS ONE 7(8):e43833 (2012) PMID 22952779 PMCID PMC3428289

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15), a divergent member of the TGF-β superfamily, is over-expressed by many common cancers including those of the prostate (PCa) and its expression is linked to cancer outcome. We have evaluated the effect of MIC-1/GDF15 overexpression on PCa developmen...
  10. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

    Nephrology Dialysis Transplantation 27(1):70 (2012) PMID 21940482

    Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum mediate anorexia and weight loss in some cancer patients and similarly elevated levels occur in chronic kidney disease (CKD). Serum MIC-1/GDF15 is also elevated in chronic inflammatory diseases and predicts atherosclerotic e...
  11. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

    PLoS ONE 7(8):e43833 (2012) PMID 22952779 PMCID PMC3428289

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15), a divergent member of the TGF-β superfamily, is over-expressed by many common cancers including those of the prostate (PCa) and its expression is linked to cancer outcome. We have evaluated the effect of MIC-1/GDF15 overexpression on PCa developmen...
  12. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.

    PLoS ONE 7(4):e34868 (2012) PMID 22514681 PMCID PMC3325923

    Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in can...
  13. The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

    Growth Factors 29(5):187 (2011) PMID 21831009

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause m...
  14. The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

    Growth Factors 29(5):187 (2011) PMID 21831009

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause m...
  15. PS1-090 The role of the TGF-βsuperfamily cytokine MIC-1/GDF15 in biology and medicine

    Cytokine 56(1):40 (2011)

  16. PS1-090 The role of the TGF-βsuperfamily cytokine MIC-1/GDF15 in biology and medicine

    Cytokine 56(1):40 (2011)

  17. Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

    Genesis 48(2):127 (2010) PMID 20049953

    CLIC1 belongs to a family of highly conserved and widely expressed intracellular chloride ion channel proteins existing in both soluble and membrane integrated forms. To study the physiological and biological role of CLIC1 in vivo, we undertook conditional gene targeting to engineer Clic1 gene k...
  18. Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

    Genesis 48(2):127 (2010) PMID 20049953

    CLIC1 belongs to a family of highly conserved and widely expressed intracellular chloride ion channel proteins existing in both soluble and membrane integrated forms. To study the physiological and biological role of CLIC1 in vivo, we undertook conditional gene targeting to engineer Clic1 gene k...
  19. 337 The TGF-β superfamily cytokine MIC-1 causes tumour-induced anorexia/cachexia by modulating appetite control centres in the hypothalamus

    Cytokine 43(3):323 (2008)

  20. 337 The TGF-β superfamily cytokine MIC-1 causes tumour-induced anorexia/cachexia by modulating appetite control centres in the hypothalamus

    Cytokine 43(3):323 (2008)