1. Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study.

    Diabetologia 59(9):1920 (2016) PMID 27333884 PMCID PMC4970938

    Low birthweight has been associated with a high risk of type 2 diabetes mellitus in observational studies. However, it remains unclear whether this relation is causal. The present study included 3627 individuals with type 2 diabetes and 12,974 control participants of European ancestry from the N...
  2. Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.

    American Journal of Epidemiology 184(4):295 (2016) PMID 27466075

    Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 d...
  3. Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

    American Journal of Clinical Nutrition 104(1):198 (2016) PMID 27281308 PMCID PMC4919524

    Diet interventions have shown effectiveness in improving diabetes risk factors; however, little is known about whether the effects of diet intervention are different according to genetic susceptibility. We examined interactions between weight-loss diets and the genetic risk score (GRS) for diabe...
  4. Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.

    Journal Of Diabetes 8(3):378 (2016) PMID 25940519

    The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China. A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
  5. Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men.

    Journal Of Diabetes 8(3):434 (2016) PMID 25991060

    The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. A population-based cross-sectional study was per...
  6. Obesity and peripheral arterial disease: A Mendelian Randomization analysis.

    Atherosclerosis 247:218 (2016) PMID 26945778

    Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomiz...
  7. Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.

    Obesity 24(3):703 (2016) PMID 26833544

    To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and mea...
  8. Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study.

    The lancet. Diabetes & endocrinology 4(2):125 (2016) PMID 26776861

    Little is known about the cardiometabolic health of internal migrant workers in China. We aimed to examine the prevalence of diabetes-related cardiometabolic risk factors in this large, but little-studied population. We did this national surveillance study within the Chinese Center for Disease C...
  9. Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism.

    Journal of Clinical Endocrinology & Metabolism 101(1):143 (2016) PMID 26523527

    Epidemiology studies showed inconsistent results regarding the relationship between bisphenol A (BPA) exposure and risk of type 2 diabetes (T2D). This study sought to prospectively investigate associations of BPA with incident T2D risk and the longitudinal changes in glycemic traits, particularl...
  10. Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study.

    Journal of the American Heart Association Cardi... 5(7) (2016) PMID 27451464

    Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear. This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10-year Framingham risk for c...
  11. Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population.

    Journal of Atherosclerosis and Thrombosis 23(2):216 (2016) PMID 26423715

    Increased carotid artery intima media thickness (C-IMT) is an early feature of atherosclerosis. It has been reported to be altered in patients with thyroid dysfunction, and the evidence is still controversial. The present study aimed to explore the relationship between C-IMT and possible variati...
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  12. Genetic Predisposition to Polycystic Ovary Syndrome, Postpartum Weight Reduction, and Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes.

    Journal of Clinical Endocrinology & Metabolism 100(12):E1560 (2015) PMID 26431507

    Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women and a major female-specific risk factor of obesity, impaired glucose tolerance, and diabetes. We examined whether the genetic variation predisposing to PCOS affected glycemic changes in women with prior gestational...
  13. Prevalence and trends in overweight and obesity among Chinese adults in 2004–10: data from three nationwide surveys in China

    The Lancet 386:S77 (2015)

    Background Obesity has become a global epidemic and is a common risk factor for many chronic diseases. Few data for the prevalence and trends in overweight and obesity in Chinese adults have been obtained over the past decade. We aimed to estimate changes in the prevalence of...
  14. Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Adults: A Cross-Sectional Study.

    Medicine (Baltimore) 94(43):e1814 (2015) PMID 26512580

    Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases.This is a cross-sectional study. From ...
  15. Diabetes genetic score, diabetes, and arterial stiffness: a Mendelian randomisation analysis in Chinese

    The Lancet 386:S53 (2015)

    Background The nature and underlying mechanisms of the association between type 2 diabetes and the risk of increased arterial stiffness are unclear. We aimed to study this association using the Mendelian randomisation approach.
  16. Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese.

    Journal of Atherosclerosis and Thrombosis 22(8):823 (2015) PMID 25740202

    The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and is directly associated with an increased risk of cardiovascular disease. Considering that the independent association between the serum uric acid level and CIMT remains controversial due to th...
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  17. Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease.

    Atherosclerosis 241(1):145 (2015) PMID 25988358

    Nonalcoholic fatty liver (NAFLD) with advanced fibrosis usually has a deteriorated prognosis, which was mainly attributed to cardiovascular cause. We investigated whether advanced fibrosis assessed by noninvasive fibrosis markers was associated with subclinical atherosclerosis in NAFLD patients....
  18. Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population.

    Journal of Lipid Research 56(4):920 (2015) PMID 25649924 PMCID PMC4373748

    Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the risk of CVD. However, the relationship between serum Lp(a) and T2D is poorly characterized, especially in the Asian po...
  19. Status of cardiovascular health in Chinese adults.

    Journal of the American College of Cardiology 65(10):1013 (2015) PMID 25766949

    Cardiovascular disease has become the leading cause of death in China. The goal of this study was to evaluate the current status of cardiovascular health in Chinese adults. Cardiovascular health data were collected from a nationally representative sample of 96,121 Chinese adults age ≥ 20 years i...
  20. Bisphenol A and the risk of cardiometabolic disorders: a systematic review with meta-analysis of the epidemiological evidence.

    Environmental Health 14(1):46 (2015) PMID 26026606 PMCID PMC4472611

    Bisphenol A (BPA) is suspected to be associated with several chronic metabolic diseases. The aim of the present study was to review the epidemiological literature on the relation between BPA exposure and the risk of cardiometabolic disorders. PubMed and Embase databases were searched up to Augus...