1. Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial.

    Alzheimer Disease and Associated Disorders 30(1):1 (2016) PMID 26885819

    Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trial enrollment. In a multicenter, phase 1b trial, patients meeting clinical criteria for prodromal or...
  2. Multiple kernel learning with random effects for predicting longitudinal outcomes and data integration.

    Biometrics 71(4):918 (2015) PMID 26177419 PMCID PMC4713389

    Predicting disease risk and progression is one of the main goals in many clinical research studies. Cohort studies on the natural history and etiology of chronic diseases span years and data are collected at multiple visits. Although, kernel-based statistical learning methods are proven to be po...
  3. Predicting cumulative risk of disease onset by redistributing weights.

    Statistics in Medicine 34(16):2427 (2015) PMID 25847392 PMCID PMC4457675

    We propose a simple approach predicting the cumulative risk of disease accommodating predictors with time-varying effects and outcomes subject to censoring. We use a nonparametric function for the coefficient of the time-varying effect and handle censoring through self-consistency equations that...
  4. Pros and cons of prostate cancer screening: associations with screening knowledge and attitudes among urban African American men.

    Journal of the National Medical Association 102(3):174 (2010) PMID 20355346

    Discussion of the pros and cons of prostate cancer screening tests, rather than routine screening, is recommended to support informed screening decisions, particularly among African American men. This study explored physician explanation of pros and cons of the prostate-specific antigen (PSA) te...
  5. Global gene expression analysis of the shoot apical meristem of maize (Zea mays L.).

    Plant Journal 52(3):391 (2007) PMID 17764504 PMCID PMC2156186

    All above-ground plant organs are derived from shoot apical meristems (SAMs). Global analyses of gene expression were conducted on maize (Zea mays L.) SAMs to identify genes preferentially expressed in the SAM. The SAMs were collected from 14-day-old B73 seedlings via laser capture microdissecti...