1. Reply to Robinson and Brown: It is the combination of ERAP1 allotypes that identifies individuals with Ankylosing Spondylitis.

    PNAS 112(15):E1817 (2015) PMID 25767099 PMCID PMC4403149

  2. The terrestrial uranium isotope cycle.

    Nature 517(7534):356 (2015) PMID 25592542

    Changing conditions on the Earth's surface can have a remarkable influence on the composition of its overwhelmingly more massive interior. The global distribution of uranium is a notable example. In early Earth history, the continental crust was enriched in uranium. Yet after the initial rise in...
  3. The terrestrial uranium isotope cycle.

    Nature 517(7534):356 (2015) PMID 25592542

    Changing conditions on the Earth's surface can have a remarkable influence on the composition of its overwhelmingly more massive interior. The global distribution of uranium is a notable example. In early Earth history, the continental crust was enriched in uranium. Yet after the initial rise in...
  4. The terrestrial uranium isotope cycle.

    Nature 517(7534):356 (2015) PMID 25592542

    Changing conditions on the Earth's surface can have a remarkable influence on the composition of its overwhelmingly more massive interior. The global distribution of uranium is a notable example. In early Earth history, the continental crust was enriched in uranium. Yet after the initial rise in...
  5. Temporal variations in the influence of the subducting slab on Central Andean arc magmas: Evidence from boron isotope systematics

    Earth and Planetary Science Letters 408:390 (2014)

    The Pampean flat-slab segment in the southern Central Andes represents an ideal setting at which to investigate how changes in the tectonic configuration of a subduction zone (convergence angles and rates, seamount subduction and shallowing slab angle) affects the recycling of subducte...
  6. Temporal variations in the influence of the subducting slab on Central Andean arc magmas: Evidence from boron isotope systematics

    Earth and Planetary Science Letters 408:390 (2014)

    The Pampean flat-slab segment in the southern Central Andes represents an ideal setting at which to investigate how changes in the tectonic configuration of a subduction zone (convergence angles and rates, seamount subduction and shallowing slab angle) affects the recycling of subducte...
  7. Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

    PNAS 111(49):17594 (2014) PMID 25422414

    For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminope...
  8. Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

    PNAS 111(49):17594 (2014) PMID 25422414 PMCID PMC4267330

    For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminope...
  9. Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

    PNAS 111(49):17594 (2014) PMID 25422414 PMCID PMC4267330

    For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminope...
  10. Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

    PNAS 111(49):17594 (2014) PMID 25422414 PMCID PMC4267330

    For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminope...
  11. ERAP1 in the pathogenesis of ankylosing spondylitis.

    Immunologic Research 60(2-3):257 (2014) PMID 25434650

    The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucle...
  12. ERAP1 in the pathogenesis of ankylosing spondylitis.

    Immunologic Research 60(2-3):257 (2014) PMID 25434650

    The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucle...
  13. ERAP1 in the pathogenesis of ankylosing spondylitis.

    Immunologic Research 60(2-3):257 (2014) PMID 25434650

    The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucle...
  14. Melting versus contamination effects on 238U–230Th–226Ra and 235U–231Pa disequilibria in lavas from São Miguel, Azores

    Chemical Geology 381:94 (2014)

    The island of São Miguel, Azores piques geochemical interest due to a strikingly large range in the long-lived radiogenic isotope ratios of its lavas. The ‘enriched’ signatures (e.g., radiogenic 87Sr/86Sr and unradiogenic 143Nd/144Nd) observed in lavas found in the east of the island h...
  15. Melting versus contamination effects on 238U–230Th–226Ra and 235U–231Pa disequilibria in lavas from São Miguel, Azores

    Chemical Geology 381:94 (2014)

    The island of São Miguel, Azores piques geochemical interest due to a strikingly large range in the long-lived radiogenic isotope ratios of its lavas. The ‘enriched’ signatures (e.g., radiogenic 87Sr/86Sr and unradiogenic 143Nd/144Nd) observed in lavas found in the east of the island h...
  16. Melting versus contamination effects on 238U–230Th–226Ra and 235U–231Pa disequilibria in lavas from São Miguel, Azores

    Chemical Geology 381:94 (2014)

    The island of São Miguel, Azores piques geochemical interest due to a strikingly large range in the long-lived radiogenic isotope ratios of its lavas. The ‘enriched’ signatures (e.g., radiogenic 87Sr/86Sr and unradiogenic 143Nd/144Nd) observed in lavas found in the east of the island h...
  17. Melting versus contamination effects on238U–230Th–226Ra and235U–231Pa disequilibria in lavas from São Miguel, Azores

    Chemical Geology 381:94 (2014)

    The island of São Miguel, Azores piques geochemical interest due to a strikingly large range in the long-lived radiogenic isotope ratios of its lavas. The ‘enriched’ signatures (e.g., radiogenic 87Sr/86Sr and unradiogenic 143Nd/144Nd) observed in lavas found in the east of the island h...
  18. Melting versus contamination effects on 238U–230Th–226Ra and 235U–231Pa disequilibria in lavas from São Miguel, Azores

    Chemical Geology 381:94 (2014)

    The island of São Miguel, Azores piques geochemical interest due to a strikingly large range in the long-lived radiogenic isotope ratios of its lavas. The ‘enriched’ signatures (e.g., radiogenic 87Sr/86Sr and unradiogenic 143Nd/144Nd) observed in lavas found in the east of the island h...
  19. Peptide-independent stabilization of MHC class I molecules breaches cellular quality control.

    Journal of Cell Science 127(Pt 13):2885 (2014) PMID 24806963

    The intracellular trafficking of major histocompatibility complex class I (MHC-I) proteins is directed by three quality control mechanisms that test for their structural integrity, which is correlated to the binding of high-affinity antigenic peptide ligands. To investigate which molecular featu...
  20. Peptide-independent stabilization of MHC class I molecules breaches cellular quality control.

    Journal of Cell Science 127(Pt 13):2885 (2014) PMID 24806963

    The intracellular trafficking of major histocompatibility complex class I (MHC-I) proteins is directed by three quality control mechanisms that test for their structural integrity, which is correlated to the binding of high-affinity antigenic peptide ligands. To investigate which molecular featu...