1. PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide.

    Journal of nuclear medicine : official publicat... 56(2):311 (2015) PMID 25613536

    Herein we aimed to evaluate the utility of N-(2,5-dimethoxybenzyl)-2-(18)F-fluoro-N-(2-phenoxyphenyl)acetamide ((18)F-PBR06) for detecting alterations in translocator protein (TSPO) (18 kDa), a biomarker of microglial activation, in a mouse model of Alzheimer's disease (AD). Wild-type (wt) and A...
  2. PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide.

    Journal of nuclear medicine : official publicat... 56(2):311 (2015) PMID 25613536

    Herein we aimed to evaluate the utility of N-(2,5-dimethoxybenzyl)-2-(18)F-fluoro-N-(2-phenoxyphenyl)acetamide ((18)F-PBR06) for detecting alterations in translocator protein (TSPO) (18 kDa), a biomarker of microglial activation, in a mouse model of Alzheimer's disease (AD). Wild-type (wt) and A...
  3. Geroscience: linking aging to chronic disease.

    Cell 159(4):709 (2014) PMID 25417146

    Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscienc...
  4. Geroscience: linking aging to chronic disease.

    Cell 159(4):709 (2014) PMID 25417146

    Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscienc...
  5. Geroscience: linking aging to chronic disease.

    Cell 159(4):709 (2014) PMID 25417146

    Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscienc...
  6. Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome.

    PAIN® 155(11):2377 (2014) PMID 25218828 PMCID PMC4252476

    Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches to tre...
  7. Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome.

    PAIN® 155(11):2377 (2014) PMID 25218828 PMCID PMC4252476

    Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches to tre...
  8. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function.

    Science 346(6205):89 (2014) PMID 25147279

    Aging-associated cognitive decline is affected by factors produced inside and outside the brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the circulation, shows a type I interferon (IFN-I)-dependent gene expressio...
  9. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

    JAMA Neurology 71(10):1228 (2014) PMID 25111166

    The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). To discover the molecular basis of this rare disorder and to determine the effects of complete absence of apoE on neurocognitive an...
  10. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

    JAMA Neurology 71(10):1228 (2014) PMID 25111166

    The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). To discover the molecular basis of this rare disorder and to determine the effects of complete absence of apoE on neurocognitive an...
  11. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

    JAMA Neurology 71(10):1228 (2014) PMID 25111166

    The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). To discover the molecular basis of this rare disorder and to determine the effects of complete absence of apoE on neurocognitive an...
  12. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

    Science Translational Medicine 6(243):243ra86 (2014) PMID 24990881

    Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and FTD-like syndrome without bone involvement. TREM2 is an innat...
  13. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

    Science Translational Medicine 6(243):243ra86 (2014) PMID 24990881

    Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and FTD-like syndrome without bone involvement. TREM2 is an innat...
  14. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

    Nature Neuroscience 17(7):943 (2014) PMID 24859199 PMCID PMC4096284

    The transforming growth factor-β (TGF-β) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective actions, its physiological role in the adult brain is unclear. We observed a prominent activation of TGF-β signaling in the adult dentate gyrus an...
  15. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

    Nature Neuroscience 17(7):943 (2014) PMID 24859199 PMCID PMC4096284

    The transforming growth factor-β (TGF-β) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective actions, its physiological role in the adult brain is unclear. We observed a prominent activation of TGF-β signaling in the adult dentate gyrus an...
  16. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

    Nature Neuroscience 17(7):943 (2014) PMID 24859199 PMCID PMC4096284

    The transforming growth factor-β (TGF-β) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective actions, its physiological role in the adult brain is unclear. We observed a prominent activation of TGF-β signaling in the adult dentate gyrus an...
  17. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

    Nature Neuroscience 17(7):943 (2014) PMID 24859199 PMCID PMC4096284

    The transforming growth factor-β (TGF-β) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective actions, its physiological role in the adult brain is unclear. We observed a prominent activation of TGF-β signaling in the adult dentate gyrus an...
  18. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

    Nature Medicine 20(6):659 (2014) PMID 24793238 PMCID PMC4224436

    As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing ef...
  19. Sorting through the roles of beclin 1 in microglia and neurodegeneration.

    Journal of NeuroImmune Pharmacology 9(3):285 (2014) PMID 24385262 PMCID PMC4019692

    Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning ...
  20. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

    Nature Medicine 20(6):659 (2014) PMID 24793238 PMCID PMC4224436

    As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing ef...