1. Do HLA-A markers predict skin-reactions from aromatic antiepileptic drugs in a Norwegian population? A case control study.

    Epilepsy Research 118:5 (2015) PMID 26555631

    Cutaneous adverse reactions (cADRs) from carbamazepine (CBZ) have been associated with human leukocyte antigens (HLA). Our aims were to assess the clinical usefulness of HLA-A*31:01 as a predictor of CBZ-induced cADRs in the Norwegian population and to explore whether cADRs from aromatic antiepi...
  2. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

    Current Biology 25(21):2878 (2015)

  3. The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.

    Current Biology 25(19):2518 (2015) PMID 26387712 PMCID PMC4714572

    Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-...
  4. Circulating immune mediators are closely linked in adult-onset type 1 diabetes as well as in non-diabetic subjects.

    Autoimmunity 47(8):530 (2014) PMID 25027869

    Relationships between circulating immune mediators (cytokines, chemokines and growth factors) and a beta cell destructive autoimmune process in adult-onset type 1 diabetes are poorly elucidated. We measured serum levels of immune mediators in type 1 diabetic patients in the context of ongoing de...
  5. Carbamazepine-induced cutaneous reactions: a simple assay to identify patients carrying the HLA-A*31:01 allele.

    Scandinavian Journal of Clinical and Laboratory... 74(7):644 (2014) PMID 24882392

    Treatment with the first-line antiepileptic drug, carbamazepine (CBZ), is associated with adverse cutaneous reactions in up to 10% of patients. One predisposition to these side-effects has been linked to the HLA-A*31:01 allele. HLA-typing is costly and time-consuming. A single nucleotide polymor...
  6. Bronchoalveolar lavage fluid IFN-γ+ Th17 cells and regulatory T cells in pulmonary sarcoidosis.

    Mediators of Inflammation 2014:438070 (2014) PMID 24882950 PMCID PMC4027000

    In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3(+) CD4(+) T cell subsets in sarcoidosis remains unclear. Bronchoa...
  7. The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269.

    Proceedings of the Royal Society B: Biological ... 279(1730):884 (2012) PMID 21865258 PMCID PMC3259916

    Recently, the debate on the origins of the major European Y chromosome haplogroup R1b1b2-M269 has reignited, and opinion has moved away from Palaeolithic origins to the notion of a younger Neolithic spread of these chromosomes from the Near East. Here, we address this debate by investigating fre...
  8. Agreement of specific IgE and skin prick test in an unselected cohort of two-year-old children.

    European Journal of Pediatrics 171(3):479 (2012) PMID 21960289

    The objective of this study was to evaluate the agreement between specific IgE (sIgE) and skin prick test (SPT), and the possible association between total IgE concentration and allergy-related disorders, when performed in an unselected cohort of 353 two-year olds. Median total IgE was within th...
  9. An e-learning course in medical immunology: does it improve learning outcome?

    Medical Teacher 34(9):e649 (2012) PMID 22497322

    E-learning is used by most medical students almost daily and several studies have shown e-learning to improve learning outcome in small-scale interventions. However, few studies have explored the effects of e-learning in immunology. To study the effect of an e-learning package in immunology on l...
  10. Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control.

    Diabetes Care 33(3):589 (2010) PMID 20028939 PMCID PMC2827514

    OBJECTIVE Continuous beta-cell rest with diazoxide preserves residual endogenous insulin production in type 1 diabetes. However, side effects have hampered therapeutic usefulness. In a double-blind study, we tested whether lower, intermittent dosing of diazoxide had beneficial effects on insulin...
  11. Biomarkers of chronic uveitis in juvenile idiopathic arthritis: predictive value of antihistone antibodies and antinuclear antibodies.

    Journal of Rheumatology 36(8):1737 (2009) PMID 19567622

    To study the predictive value of antinuclear autoantibody (ANA) tests and antihistone antibodies (AHA) as risk factors for development of chronic asymptomatic uveitis of insidious onset in juvenile idiopathic arthritis (JIA). ANA by indirect immunofluorescence using HEp-2 cells (IF-ANA), ELISA f...
  12. Cutaneous T cell lymphoma and graft-versus-host disease: A comparison ofin vivoeffects of extracorporeal photochemotherapy on Foxp3+ regulatory T cells

    Clinical Immunology 133(3):303 (2009) PMID 19773201

    Extracorporeal photochemotherapy (ECP) is a well established treatment for both cutaneous T cell lymphoma (CTCL) and graft-versus-host disease (GVHD). However, the general effector mechanism is not fully settled. Twenty-four patients with CTCL and 14 patients with GVHD were included to asse...
  13. [High-dose treatment with autologous stem cell support in a Norwegian region].

    Tidsskrift for Den norske legeforening 124(19):2498 (2004) PMID 15477890

    The introduction of high-dose treatment with autologous stem cell support (HMAS) in Norwegian regional hospitals in the early 1990s was controversial. Concerns that low numbers of patients would lead to unacceptably low quality were expressed. We present treatment results in the health region of...
  14. A Y Chromosome Census of the British Isles

    Current Biology 13(11):979 (2003)

    The degree of population replacement in the British Isles associated with cultural changes has been extensively debated [1–3]. Recent work has demonstrated that comparisons of genetic variation in the British Isles and on the European Continent can illuminate specific demographic proce...
  15. A Y chromosome census of the British Isles.

    Current Biology 13(11):979 (2003) PMID 12781138

    The degree of population replacement in the British Isles associated with cultural changes has been extensively debated. Recent work has demonstrated that comparisons of genetic variation in the British Isles and on the European Continent can illuminate specific demographic processes in the hist...
  16. [Antineutrophil cytoplasmic autoantibodies in systemic vasculitis].

    Tidsskrift for Den norske legeforening 122(12):1185 (2002) PMID 12089844

    Antineutrophil cytoplasmic autoantibodies (ANCA) are directed against antigens located in the cytoplasm of neutrophil granulocytes and monocytes. Detection of ANCA has proved to be a useful diagnostic tool for a group of systemic vasculitis, especially Wegener's granulomatosis. Both indirect imm...
  17. Immune-mediated fever in the dog. Occurrence of antinuclear antibodies, rheumatoid factor, tumor necrosis factor and interleukin-6 in serum.

    Acta Veterinaria Scandinavica 43(3):165 (2002) PMID 12564546 PMCID PMC1764186

    Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extractable nucl...
  18. Juvenile myoclonic epilepsy and human leukocyte antigens

    Seizure 4(2):119 (1995)

    The idiopathic generalized epilepsies (IGE) occur with a high aggregation within families. Juvenile myoclonic epilepsy (JME) is recognized as a commonly occurring form of idiopathic generalized epilepsy. A possible association between JME and HLA antigens was investigated by serological typ...
  19. Production of interleukin 2 containing growth medium for cloning of human T lymphocytes

    Journal of Immunological Methods 71(2):175 (1984)

    Culture conditions which would enhance production of interleukin 2 (IL-2) from PHA-stimulated peripheral blood mononuclear cells (PBM) were studied. One thousand rads. irradiation of the cells was found to alter the kinetics and to increase the production of IL-2. Addition of indomethacin o...