1. The impact of uric acid on long-term mortality in patients with asymptomatic carotid atherosclerotic disease.

    Journal of Stroke and Cerebrovascular Diseases 24(2):354 (2015) PMID 25498736

    Serum uric acid (SUA) has been discussed to be related to cardiovascular (CV) disease and outcome. We investigated whether levels of SUA predict long-term mortality in neurologically asymptomatic patients with carotid atherosclerotic disease. We prospectively studied 959 consecutive patients wit...
  2. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.

    Nature Communications 6:6496 (2015) PMID 25754093

    Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding pr...
  3. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.

    Journal of Biological Chemistry 289(51):35503 (2014) PMID 25371201 PMCID PMC4271235

    The transcription factor Hes3 is a component of a signaling pathway that supports the growth of neural stem cells with profound consequences in neurodegenerative disease models. Here we explored whether Hes3 also regulates pancreatic islet cells. We showed that Hes3 is expressed in human and rod...
  4. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.

    Journal of Biological Chemistry 289(51):35503 (2014) PMID 25371201

    The transcription factor Hes3 is a component of a signaling pathway that supports the growth of neural stem cells with profound consequences in neurodegenerative disease models. Here we explored whether Hes3 also regulates pancreatic islet cells. We showed that Hes3 is expressed in human and rod...
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  5. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.

    Journal of Biological Chemistry 289(51):35503 (2014) PMID 25371201 PMCID PMC4271235

    The transcription factor Hes3 is a component of a signaling pathway that supports the growth of neural stem cells with profound consequences in neurodegenerative disease models. Here we explored whether Hes3 also regulates pancreatic islet cells. We showed that Hes3 is expressed in human and rod...
  6. α3β1 is INTEGRAL to septic neutrophils.

    Blood 124(24):3507 (2014) PMID 25477480

  7. α3β1 is INTEGRAL to septic neutrophils.

    Blood 124(24):3507 (2014) PMID 25477480

  8. α3β1 is INTEGRAL to septic neutrophils.

    Blood 124(24):3507 (2014) PMID 25477480

  9. Immune cell crosstalk in obesity: a key role for costimulation?

    Diabetes 63(12):3982 (2014) PMID 25414012

    In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflamma...
  10. Immune cell crosstalk in obesity: a key role for costimulation?

    Diabetes 63(12):3982 (2014) PMID 25414012

    In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflamma...
  11. Immune cell crosstalk in obesity: a key role for costimulation?

    Diabetes 63(12):3982 (2014) PMID 25414012

    In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflamma...
  12. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.

    International Journal of Cancer 135(9):2054 (2014) PMID 24676840

    Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism...
  13. A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase.

    Molecular Biology of the Cell 25(19):2948 (2014) PMID 25057020 PMCID PMC4230584

    Rapid β2-integrin activation is indispensable for leukocyte adhesion and recruitment to sites of infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out signaling. Here we uncovered a novel pathway for rapid activation of integrin-dependent leukocyte adhesi...
  14. A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase.

    Molecular Biology of the Cell 25(19):2948 (2014) PMID 25057020 PMCID PMC4230584

    Rapid β2-integrin activation is indispensable for leukocyte adhesion and recruitment to sites of infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out signaling. Here we uncovered a novel pathway for rapid activation of integrin-dependent leukocyte adhesi...
  15. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation.

    Hepatology 60(4):1196 (2014) PMID 24845056

    The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to th...
  16. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium.

    International Journal of Radiation Biology 90(8):700 (2014) PMID 24512568

    In this work we examined the presence of the neural stem cell biomarker Hairy and Enhancer of Split 3 (Hes3) in the anterior eye segment and in the aberrant growth condition of the conjunctiva pterygium. Further, we studied the response of Hes3 to irradiation. Adult mouse and human corneoscleral...
  17. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.

    Journal of Immunology 193(3):1383 (2014) PMID 24958900 PMCID PMC4108495

    The glycoprotein milk fat globule-epidermal growth factor factor 8 (MFG-E8) is expressed in several tissues and mediates diverse homeostatic functions. However, whether it plays a role in bone homeostasis has not been established. In this study, we show for the first time, to our knowledge, that...
  18. A defined, controlled culture system for primary bovine chromaffin progenitors reveals novel biomarkers and modulators.

    Stem Cells Translational Medicine 3(7):801 (2014) PMID 24855275 PMCID PMC4073824

    We present a method to efficiently culture primary chromaffin progenitors from the adult bovine adrenal medulla in a defined, serum-free monolayer system. Tissue is dissociated and plated for expansion under support by the mitogen basic fibroblast growth factor (bFGF). The cultures, although not...
  19. Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin.

    Thrombosis and Haemostasis 111(5):1004 (2014) PMID 24352615 PMCID PMC4013214

  20. Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss.

    Science Translational Medicine 6(229):229ra40 (2014) PMID 24670684 PMCID PMC4090608

    Leukocyte adhesion deficiency type I (LAD-I), a disease syndrome associated with frequent microbial infections, is caused by mutations on the CD18 subunit of β₂ integrins. LAD-I is invariably associated with severe periodontal bone loss, which historically has been attributed to the lack of neut...