1. Simulating calcium influx and free calcium concentrations in yeast.

    Cell Calcium 45(2):123 (2009) PMID 18783827 PMCID PMC3130064

    Yeast can proliferate in environments containing very high Ca(2+) primarily due to the activity of vacuolar Ca(2+) transporters Pmc1 and Vcx1. Yeast mutants lacking these transporters fail to grow in high Ca(2+) environments, but growth can be restored by small increases in environmental Mg(2+)....
  2. Simulating calcium influx and free calcium concentrations in yeast

    Cell Calcium 45(2):123 (2009)

    Yeast can proliferate in environments containing very high Ca 2+ primarily due to the activity of vacuolar Ca 2+ transporters Pmc1 and Vcx1. Yeast mutants lacking these transporters fail to grow in high Ca 2+ environments, but growth can be restored by small increases in e...
  3. Simulating calcium influx and free calcium concentrations in yeast

    Cell Calcium 45(2):123 (2009) PMID 18783827 PMCID PMC3130064

    Yeast can proliferate in environments containing very high Ca 2+ primarily due to the activity of vacuolar Ca 2+ transporters Pmc1 and Vcx1. Yeast mutants lacking these transporters fail to grow in high Ca 2+ environments, but growth can be restored by small increases in e...
  4. Simulating calcium influx and free calcium concentrations in yeast

    Cell Calcium 45(2):123 (2009) PMID 18783827 PMCID PMC3130064

    Yeast can proliferate in environments containing very high Ca 2+ primarily due to the activity of vacuolar Ca 2+ transporters Pmc1 and Vcx1. Yeast mutants lacking these transporters fail to grow in high Ca 2+ environments, but growth can be restored by small increases in e...
  5. Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.

    Nature Genetics 40(8):963 (2008) PMID 18641651 PMCID PMC3979291

    Mutations in genes encoding ribosomal proteins cause the Minute phenotype in Drosophila and mice, and Diamond-Blackfan syndrome in humans. Here we report two mouse dark skin (Dsk) loci caused by mutations in Rps19 (ribosomal protein S19) and Rps20 (ribosomal protein S20). We identify a common pa...
  6. Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.

    Nature Genetics 40(8):963 (2008) PMID 18641651 PMCID PMC3979291

    Mutations in genes encoding ribosomal proteins cause the Minute phenotype in Drosophila and mice, and Diamond-Blackfan syndrome in humans. Here we report two mouse dark skin (Dsk) loci caused by mutations in Rps19 (ribosomal protein S19) and Rps20 (ribosomal protein S20). We identify a common pa...
  7. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo.

    PNAS 104(45):17747 (2007) PMID 17965232 PMCID PMC2077026

    Telomeres protect chromosome ends and serve as a substrate for telomerase, a reverse transcriptase that adds DNA repeats to the telomere terminus. In the absence of telomerase, telomeres progressively shorten, ultimately leading to telomere uncapping, a structural change at the telomere that act...
  8. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo.

    PNAS 104(45):17747 (2007) PMID 17965232 PMCID PMC2077026

    Telomeres protect chromosome ends and serve as a substrate for telomerase, a reverse transcriptase that adds DNA repeats to the telomere terminus. In the absence of telomerase, telomeres progressively shorten, ultimately leading to telomere uncapping, a structural change at the telomere that act...
  9. Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis.

    Journal of Biological Chemistry 278(31):28831 (2003) PMID 12754197

    The antiarrhythmic drug amiodarone was recently demonstrated to have novel broad range fungicidal activity. We provide evidence that amiodarone toxicity is mediated by disruption of Ca2+ homeostasis in Saccharomyces cerevisiae. In mutants lacking calcineurin and various Ca2+ transporters, includ...
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  10. Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis.

    Journal of Biological Chemistry 278(31):28831 (2003) PMID 12754197

    The antiarrhythmic drug amiodarone was recently demonstrated to have novel broad range fungicidal activity. We provide evidence that amiodarone toxicity is mediated by disruption of Ca2+ homeostasis in Saccharomyces cerevisiae. In mutants lacking calcineurin and various Ca2+ transporters, includ...
    PDF not found