1. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.

    Journal of Neuroscience 35(19):7626 (2015) PMID 25972186 PMCID PMC4429159

    The superficial dorsal horn of the spinal cord contains numerous inhibitory interneurons, which regulate the transmission of information perceived as touch, pain, or itch. Despite the importance of these cells, our understanding of their roles in the neuronal circuitry is limited by the difficul...
  2. The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs

    Cell 160(5):1027 (2015)

  3. The cellular and molecular basis of direction selectivity of Aδ-LTMRs.

    Cell 159(7):1640 (2014) PMID 25525881 PMCID PMC4297767

    The perception of touch, including the direction of stimulus movement across the skin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin. Here, we show that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral ...
  4. The sensory neurons of touch.

    Neuron 79(4):618 (2013) PMID 23972592 PMCID PMC3811145

    The somatosensory system decodes a wide range of tactile stimuli and thus endows us with a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback and social exchange. The first step leading to perception of innocuous touch is activation of cutaneous sensory ne...
  5. The sensory neurons of touch.

    Neuron 79(4):618 (2013) PMID 23972592 PMCID PMC3811145

    The somatosensory system decodes a wide range of tactile stimuli and thus endows us with a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback and social exchange. The first step leading to perception of innocuous touch is activation of cutaneous sensory ne...
  6. The Sensory Neurons of Touch

    Neuron 79(4):618 (2013)

    The somatosensory system decodes a wide range of tactile stimuli and thus endows us with a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback and social exchange. The first step leading to perception of innocuous touch is activation of cutaneous ...
  7. Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.

    PLoS ONE 7(1):e29495 (2012) PMID 22253730 PMCID PMC3257225

    The vestibular apparatus of the vertebrate inner ear uses three fluid-filled semicircular canals to sense angular acceleration of the head. Malformation of these canals disrupts the sense of balance and frequently causes circling behavior in mice. The Epistatic circler (Ecl) is a complex mutant ...
  8. Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.

    PLoS ONE 7(1):e29495 (2012) PMID 22253730 PMCID PMC3257225

    The vestibular apparatus of the vertebrate inner ear uses three fluid-filled semicircular canals to sense angular acceleration of the head. Malformation of these canals disrupts the sense of balance and frequently causes circling behavior in mice. The Epistatic circler (Ecl) is a complex mutant ...
  9. The functional organization of cutaneous low-threshold mechanosensory neurons.

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin an...
  10. The functional organization of cutaneous low-threshold mechanosensory neurons.

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin an...
  11. Control of Neuronal Morphology by the Atypical Cadherin Fat3

    Neuron 71(5):820 (2011)

    Neurons receive signals through dendrites that vary widely in number and organization, ranging from one primary dendrite to multiple complex dendritic trees. For example, retinal amacrine cells (ACs) project primary dendrites into a discrete synaptic layer called the inner plexiform la...
  12. Control of neuronal morphology by the atypical cadherin Fat3.

    Neuron 71(5):820 (2011) PMID 21903076 PMCID PMC3521586

    Neurons receive signals through dendrites that vary widely in number and organization, ranging from one primary dendrite to multiple complex dendritic trees. For example, retinal amacrine cells (ACs) project primary dendrites into a discrete synaptic layer called the inner plexiform layer (IPL) ...
  13. Control of neuronal morphology by the atypical cadherin Fat3.

    Neuron 71(5):820 (2011) PMID 21903076 PMCID PMC3521586

    Neurons receive signals through dendrites that vary widely in number and organization, ranging from one primary dendrite to multiple complex dendritic trees. For example, retinal amacrine cells (ACs) project primary dendrites into a discrete synaptic layer called the inner plexiform layer (IPL) ...
  14. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.

    PLoS ONE 5(2):e8981 (2010) PMID 20126551 PMCID PMC2813878

    The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is not known. However, Lrig proteins contain...
  15. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.

    PLoS ONE 5(2):e8981 (2010) PMID 20126551 PMCID PMC2813878

    The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is not known. However, Lrig proteins contain...
  16. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.

    Development 135(24):4091 (2008) PMID 19004851 PMCID PMC2892390

    The sense of balance depends on the intricate architecture of the inner ear, which contains three semicircular canals used to detect motion of the head in space. Changes in the shape of even one canal cause drastic behavioral deficits, highlighting the need to understand the cellular and molecul...
  17. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.

    Development 135(24):4091 (2008) PMID 19004851 PMCID PMC2892390

    The sense of balance depends on the intricate architecture of the inner ear, which contains three semicircular canals used to detect motion of the head in space. Changes in the shape of even one canal cause drastic behavioral deficits, highlighting the need to understand the cellular and molecul...
  18. The Ig superfamily protein Lrig3 controls inner ear morphogenesis by regulating Netrin-1 expression

    Developmental Biology 319(2):504 (2008)

  19. Changes in Sef levels influence auditory brainstem development and function.

    Journal of Neuroscience 27(16):4273 (2007) PMID 17442811

    During development of the CNS, secreted morphogens of the fibroblast growth factor (FGF) family have multiple effects on cell division, migration, and survival depending on where, when, and how much FGF signal is received. The consequences of misregulating the FGF pathway were studied in a mouse...
  20. Changes in Sef levels influence auditory brainstem development and function.

    Journal of Neuroscience 27(16):4273 (2007) PMID 17442811

    During development of the CNS, secreted morphogens of the fibroblast growth factor (FGF) family have multiple effects on cell division, migration, and survival depending on where, when, and how much FGF signal is received. The consequences of misregulating the FGF pathway were studied in a mouse...