1. Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish.

    Developmental & Comparative Immunology 52(2):182 (2015) PMID 26027798

    Prostaglandins (PGs) play a key role in the development on the immune response through the regulation of both pro- and anti-inflammatory processes. PGD2 can be either pro- or anti-inflammatory depending on the inflammatory milieu. Prostaglandin D synthase (PGDS) is the enzyme responsible for the...
  2. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish

    Developmental & Comparative Immunology 50(2):155 (2015) PMID 25681741

    • Zebrafish Rp105 and Md1 were identified. • Md1 binds both Rp105 and Tlr4 in zebrafish. • Md1 or Rp1...
  3. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish

    Developmental & Comparative Immunology 50(2):155 (2015)

    • Zebrafish Rp105 and Md1 were identified. • Md1 binds both Rp105 and Tlr4 in zebrafish. • Md1 or Rp1...
  4. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

    Developmental & Comparative Immunology 49(1):44 (2015) PMID 25445910

    In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated infla...
  5. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

    Developmental & Comparative Immunology 49(1):44 (2015) PMID 25445910

    In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated infla...
  6. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium

    Developmental & Comparative Immunology 49(1):44 (2015)

    • Zebrafish Cxcl8-l1 and Cxcl8-l2 are both induced upon infection. • cxcl8-deficient larvae show reduced neutrophil recruitment to the infection site. ...
  7. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

    Developmental & Comparative Immunology 49(1):44 (2015) PMID 25445910

    In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated infla...
  8. Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications.

    Journal of Immunology 194(4):1523 (2015) PMID 25582859

    DUOX1-derived hydrogen peroxide (H2O2) and CXCL8 are two key neutrophil chemoattractants. H2O2 is critical at the early phase, whereas CXCL8 plays a key role in the late phases of recruitment, but the crosstalks between the two phases in vivo remain unknown. In this study using zebrafish, we rep...
  9. Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications.

    Journal of Immunology 194(4):1523 (2015) PMID 25582859

    DUOX1-derived hydrogen peroxide (H2O2) and CXCL8 are two key neutrophil chemoattractants. H2O2 is critical at the early phase, whereas CXCL8 plays a key role in the late phases of recruitment, but the crosstalks between the two phases in vivo remain unknown. In this study using zebrafish, we rep...
  10. Effects of recombinant flagellin B and its ND1 domain from Vibrio anguillarum on macrophages from gilthead seabream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss, W.).

    Fish & Shellfish Immunology 42(1):144 (2015) PMID 25449380

    Flagellin is the principal component of flagellum in Gram negative and positive bacteria, and it is also the ligand that activates the Toll-like receptor 5 (TLR5) in mammals and fish. In higher vertebrates, flagellin induces the activation of the membrane-bound TLR5 (TLR5M), which promotes the e...
  11. Effects of recombinant flagellin B and its ND1 domain from Vibrio anguillarum on macrophages from gilthead seabream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss, W.).

    Fish & Shellfish Immunology 42(1):144 (2015) PMID 25449380

    Flagellin is the principal component of flagellum in Gram negative and positive bacteria, and it is also the ligand that activates the Toll-like receptor 5 (TLR5) in mammals and fish. In higher vertebrates, flagellin induces the activation of the membrane-bound TLR5 (TLR5M), which promotes the e...
  12. Effects of recombinant flagellin B and its ND1 domain from Vibrio anguillarum on macrophages from gilthead seabream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss, W.)

    Fish & Shellfish Immunology 42(1):144 (2015)

    Flagellin is the principal component of flagellum in Gram negative and positive bacteria, and it is also the ligand that activates the Toll-like receptor 5 (TLR5) in mammals and fish. In higher vertebrates, flagellin induces the activation of the membrane-bound TLR5 (TLR5M), which prom...
  13. Proinflammatory signaling regulates hematopoietic stem cell emergence.

    Cell 159(5):1070 (2014) PMID 25416946 PMCID PMC4243083

    Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the lifetime of an organism. In vertebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising the floor of the dorsal aorta during a brief developmental window. To date...
  14. Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

    Cell 159(5):1070 (2014)

    Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the lifetime of an organism. In vertebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising the floor of the dorsal aorta during a brief developmental windo...
  15. Proinflammatory signaling regulates hematopoietic stem cell emergence.

    Cell 159(5):1070 (2014) PMID 25416946 PMCID PMC4243083

    Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the lifetime of an organism. In vertebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising the floor of the dorsal aorta during a brief developmental window. To date...
  16. Proinflammatory signaling regulates hematopoietic stem cell emergence.

    Cell 159(5):1070 (2014) PMID 25416946 PMCID PMC4243083

    Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the lifetime of an organism. In vertebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising the floor of the dorsal aorta during a brief developmental window. To date...
  17. Flagellin from Marinobacter algicola and Vibrio vulnificus activates the innate immune response of gilthead seabream.

    Developmental & Comparative Immunology 47(1):160 (2014) PMID 25020195

    Adjuvants have emerged as the best tools to enhance the efficacy of vaccination. However, the traditional adjuvants used in aquaculture may cause adverse alterations in fish making necessary the development of new adjuvants able to stimulate the immune system and offer strong protection against ...
  18. Flagellin from Marinobacter algicola and Vibrio vulnificus activates the innate immune response of gilthead seabream.

    Developmental & Comparative Immunology 47(1):160 (2014) PMID 25020195

    Adjuvants have emerged as the best tools to enhance the efficacy of vaccination. However, the traditional adjuvants used in aquaculture may cause adverse alterations in fish making necessary the development of new adjuvants able to stimulate the immune system and offer strong protection against ...
  19. Histamine regulates the inflammatory response of the tunicate Styela plicata

    Developmental & Comparative Immunology 46(2):382 (2014)

    • Styela plicata hemocytes release histamine upon stimulation with PAMPs. • Hemocyte phagocytosis was regulated by histamine and histamine receptor agonists. ...
  20. Histamine regulates the inflammatory response of the tunicate Styela plicata.

    Developmental & Comparative Immunology 46(2):382 (2014) PMID 24892817

    Histamine is stored inside hemocytes of the tunicate Styela plicata (Chordata, Tunicata, Ascidiacea), but no evidence on its role in the regulation of the immune response of this species has been reported. We examined whether histamine participated in the regulation of inflammation and host defe...