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  1. Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish.

    Developmental & Comparative Immunology 52(2):182 (2015) PMID 26027798

    Prostaglandins (PGs) play a key role in the development on the immune response through the regulation of both pro- and anti-inflammatory processes. PGD2 can be either pro- or anti-inflammatory depending on the inflammatory milieu. Prostaglandin D synthase (PGDS) is the enzyme responsible for the...
  2. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish

    Developmental & Comparative Immunology 50(2):155 (2015) PMID 25681741

    • Zebrafish Rp105 and Md1 were identified. • Md1 binds both Rp105 and Tlr4 in zebrafish. • Md1 or Rp1...
  3. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

    Developmental & Comparative Immunology 49(1):44 (2015) PMID 25445910

    In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated infla...
  4. Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications.

    Journal of Immunology 194(4):1523 (2015) PMID 25582859

    DUOX1-derived hydrogen peroxide (H2O2) and CXCL8 are two key neutrophil chemoattractants. H2O2 is critical at the early phase, whereas CXCL8 plays a key role in the late phases of recruitment, but the crosstalks between the two phases in vivo remain unknown. In this study using zebrafish, we rep...
  5. Proinflammatory signaling is required for hematopoietic stem cell emergence

    Experimental Hematology 42(8):S6 (2014)

  6. Fish granulocytes express a constitutively active androgen receptor variant

    Developmental & Comparative Immunology 45(1):115 (2014) PMID 24509065

    • A constitutively active AR variant, ARΔLBD, was identified in gilthead seabream. • ARΔLBD expression is regulated by testosterone in reproductive and immune orga...
  7. ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-κB activation.

    Journal of Immunology 192(12):5710 (2014) PMID 24842759

    Dual oxidase 1 (Duox1) is the NADPH oxidase responsible for the H2O2 gradient formed in tissues after injury to trigger the early recruitment of leukocytes. Little is known about the signals that modulate H2O2 release from DUOX1 and whether the H2O2 gradient can orchestrate the inflammatory resp...
  8. Flagellin from Marinobacter algicola and Vibrio vulnificus activates the innate immune response of gilthead seabream

    Developmental & Comparative Immunology 47(1) (2014) PMID 25020195

    • Marinobacter algicola (MA) and Vibrio vulnificus (Vvul) flagellins were produced. • MA and Vvul flagellins activate seabream innate immunity in vivo and in vitro...
  9. Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation.

    PLoS Biology 12(5):e1001855 (2014) PMID 24802997 PMCID PMC4011677

    TNFα overexpression has been associated with several chronic inflammatory diseases, including psoriasis, lichen planus, rheumatoid arthritis, and inflammatory bowel disease. Paradoxically, numerous studies have reported new-onset psoriasis and lichen planus following TNFα antagonist therapy. Her...
  10. Modulation of leukocytic populations of gilthead sea bream (Sparus aurata) by the intestinal parasite Enteromyxum leei (Myxozoa: Myxosporea).

    Parasitology 141(3):425 (2014) PMID 24230459

    SUMMARY The cellular mucosal and systemic effectors of gilthead sea bream (GSB) (Sparus aurata) involved in the acute immune response to the intestinal parasite Enteromyxum leei were studied in fish experimentally infected by the anal route. In the intestinal inflammatory infiltrates and in lymp...