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  1. Response to Boyle et al.

    Immunity 38(3):400 (2013) PMID 23521877

  2. Toll-like receptor 22 of gilthead seabream, Sparus aurata: molecular cloning, expression profiles and post-transcriptional regulation.

    Developmental & Comparative Immunology 44(1):173 (2014) PMID 24333435

    TLR22 is a fish-specific TLR that recognizes dsRNAs. In the present study, a TLR22 homologue gene from gilthead seabream (sbTLR22) was identified and characterized. The full coding sequence contained a single open-reading frame of 2895 nucleotides encoding a predicted protein of 964 amino acids in l...
  3. Recombinant TNFα as oral vaccine adjuvant protects European sea bass against vibriosis: insights into the role of the CCL25/CCR9 axis.

    Fish & Shellfish Immunology 35(4):1260 (2013) PMID 23932985

    We found along the trial, over expressed transcripts of genes encoding cytokines and antimicrobial molecules at the gut of rTNFα supplied group. Orally immunized fish with vaccine alone confer protection against V. anguillarum challenge throughout a short time period. In contrast, adjuvant-treated g...
  4. Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response.

    Journal of Immunology 190(8):4349 (2013) PMID 23509368 PMCID PMC3736093

    We show that both Cxcl8 genes are upregulated in response to an acute inflammatory stimulus, and that both are crucial for normal neutrophil recruitment to the wound and normal resolution of inflammation. Additionally, we have analyzed neutrophil migratory behavior through tissues to the site of inj...
  5. Modulation of leukocytic populations of gilthead sea bream (Sparus aurata) by the intestinal parasite Enteromyxum leei (Myxozoa: Myxosporea)...

    Parasitology 141(3):425 (2014) PMID 24230459

    These results suggest that the cellular response of GSB to E. leei includes proliferation of leukocytes in lymphohaematopoietic organs and recruitment into intestines via blood circulation involving elements of innate and adaptive immunity. Acidophilic granulocytes and mast cells presented opposite...
  6. Testosterone implants modify the steroid hormone balance and the gonadal physiology of gilthead seabream (Sparus aurata L.) males.

    The Journal of Steroid Biochemistry and Molecul... 138:183 (2013) PMID 23743364

    We used the in situ forming microparticle (ISM) system containing 1mg of testosterone (T)/kg body weight (T-ISM) in a homogenous population of gilthead seabream at testicular involution stage to study in vivo the effects of T on the sex steroid hormone balance and on the physiology of the gilthead s...
  7. Acidophilic granulocytes in the gills of gilthead seabream Sparus aurata: evidence for their responses to a natural infection by a copepod e...

    Cell and Tissue Research 353(3):465 (2013) PMID 23644766

    We show, for the first time in S. aurata infected gills, that AGs rather than MCs are recruited and involved in the response to E. lizae infection in seabream....
  8. Effects of administration of probiotic strains on GALT of larval gilthead seabream: Immunohistochemical and ultrastructural studies

    Fish & Shellfish Immunology 22(1):57 (2007) PMID 16730458

    These results point to a stimulatory effect of probiotics on the gut immune system that correlates with improvement of fry survival....
  9. Characterization of ATP-gated P2X7receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleuk...

    Molecular Immunology 44(6):1286 (2007) PMID 16837047

    We have cloned the P2X 7 receptor from the bony fish seabream and compared agonist and antagonist profiles at this and other non-mammalian P2X 7 receptors expressed in HEK cells, as well in seabream SAF-1 cells expressing endogenous P2X 7 receptors. We used this information to furt...
  10. Premature aging in telomerase-deficient zebrafish.

    Disease Models & Mechanisms 6(5):1101 (2013) PMID 23744274 PMCID PMC3759330

    We have characterized telomerase-deficient zebrafish (Danio rerio) as the second vertebrate model for human telomerase-driven diseases. We found that telomerase-deficient zebrafish show p53-dependent premature aging and reduced lifespan in the first generation, as occurs in humans but not in mice, p...