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  1. Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response.

    Journal of Immunology 190(8):4349 (2013) PMID 23509368 PMCID PMC3736093

    We show that both Cxcl8 genes are upregulated in response to an acute inflammatory stimulus, and that both are crucial for normal neutrophil recruitment to the wound and normal resolution of inflammation. Additionally, we have analyzed neutrophil migratory behavior through tissues to the site of inj...
  2. Histamine regulates the inflammatory response of the tunicate Styela plicata.

    Developmental & Comparative Immunology 46(2):382 (2014) PMID 24892817

    We examined whether histamine participated in the regulation of inflammation and host defense in S. plicata. The presence of histamine inside S. plicata hemocytes was confirmed by flow cytometry, and histamine release was detected by ELISA, after in vitro hemocyte stimulation with different PAMPs. I...
  3. Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analy...

    Molecular Immunology 48(9):1073 (2011) PMID 21354627

    We report that both zebrafish IFNγ genes were unable to protect zebrafish larvae against viral infection, despite the fact that they moderately induced the expression of antiviral genes, strongly induced pro-inflammatory and antigen processing and presentation genes, and increased neutrophil numbers...
  4. Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development.

    PNAS 109(39):E2605 (2012) PMID 22949679 PMCID PMC3465450

    We show that colonization by commensals in newly hatched zebrafish primes neutrophils and induces several genes encoding proinflammatory and antiviral mediators, increasing the resistance of larvae to viral infection. Commensal microbe recognition was found to be mediated mainly through a TLR/MyD88...
  5. TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor ...

    Molecular Immunology 48(6):846 (2011) PMID 21216011

    We examined the ability of toll-like receptor agonists to extend the lifespan of gilthead seabream ( Sparus aurata L.) acidophilic granulocytes, which are the functional equivalent of mammalian neutrophils. The results obtained demonstrated that apoptosis was also the default state of seabream...
  6. New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display ...

    Journal of Immunology 182(6):3440 (2009) PMID 19265122

    We are reporting in this study that zebrafish IFN (zfIFN) gamma failed to induce antiviral and proinflammatory genes when administered in vivo, which correlates with its inability to protect the fish against bacterial and viral infections. We also found that, although both group I (i.e., zfIFN1) and...
  7. The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabreamSparus auratais strongly induced after infection and tightly ...

    Molecular Immunology 44(10):2772 (2007) PMID 17234266

    Interleukin-1β (IL-1β) is the prototypic pro-inflammatory cytokine. All the biological effects of IL-1β are mediated through interaction with type 1 IL-1 receptor (IL-1RI), whereas another receptor, called type 2 IL-1R (IL-1RII), lacks an intracellular signalling domain and acts as a decoy rece...
  8. Effects of administration of probiotic strains on GALT of larval gilthead seabream: Immunohistochemical and ultrastructural studies

    Fish & Shellfish Immunology 22(1):57 (2007) PMID 16730458

    These results point to a stimulatory effect of probiotics on the gut immune system that correlates with improvement of fry survival....
  9. Characterization of ATP-gated P2X7receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleuk...

    Molecular Immunology 44(6):1286 (2007) PMID 16837047

    We have cloned the P2X 7 receptor from the bony fish seabream and compared agonist and antagonist profiles at this and other non-mammalian P2X 7 receptors expressed in HEK cells, as well in seabream SAF-1 cells expressing endogenous P2X 7 receptors. We used this information to furt...
  10. Viral nervous necrosis virus persistently replicates in the central nervous system of asymptomatic gilthead seabream and promotes a transien...

    Developmental & Comparative Immunology 37(3-4):429 (2012) PMID 22402274

    We report that VNNV was able to replicate and persist for up to 3 months in the CNS of the gilthead seabream without causing any neural damage. In addition, we found an early inflammatory response in the CNS that was characterized by the induction of genes encoding pro-inflammatory cytokines, a dela...