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  1. Editorial: Fish neutrophils meet proresolving eicosanoids.

    Journal of Leukocyte Biology 99(2):227 (2016) PMID 26830729

  2. TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity.

    Journal of Immunology 196(2):738 (2016) PMID 26673139

    As an organism is exposed to pathogens during very early development, specific defense mechanisms must take effect. In this study, we used a germ-free zebrafish embryo model to show that osmotic stress regulates the activation of immunity and host protection in newly hatched embryos. Mechanistic...
  3. Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish.

    Developmental & Comparative Immunology 53(1):55 (2015) PMID 26133072

    Although several studies have demonstrated the ability of some endocrine disruptive chemicals (EDCs) to alter the physiology of zebrafish, the immune-reproductive interaction has received little attention in this species. In this study, we used a homozygous line carrying an insertion of 8 amino ...
  4. A synthetic peptide derived from the D1 domain of flagellin induced the expression of proinflammatory cytokines in fish macrophages.

    Fish & Shellfish Immunology 47(1):239 (2015) PMID 26363237

    Flagellin is the main protein component of flagellum in Gram negative and positive bacteria, and it is also the ligand that activates the Toll-like receptor 5 (TLR5) in fish and mammals. In higher vertebrates, flagellin induces the activation of the membrane-bound TLR5 (TLR5M), which promotes th...
  5. Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish.

    Developmental & Comparative Immunology 52(2):182 (2015) PMID 26027798

    Prostaglandins (PGs) play a key role in the development on the immune response through the regulation of both pro- and anti-inflammatory processes. PGD(2) can be either pro- or anti-inflammatory depending on the inflammatory milieu. Prostaglandin D synthase (PGDS) is the enzyme responsible for t...
  6. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish.

    Developmental & Comparative Immunology 50(2):155 (2015) PMID 25681741

    TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative regulators of LPS signali...
  7. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

    Developmental & Comparative Immunology 49(1):44 (2015) PMID 25445910

    In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated infla...
  8. Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications.

    Journal of Immunology 194(4):1523 (2015) PMID 25582859

    DUOX1-derived hydrogen peroxide (H2O2) and CXCL8 are two key neutrophil chemoattractants. H2O2 is critical at the early phase, whereas CXCL8 plays a key role in the late phases of recruitment, but the crosstalks between the two phases in vivo remain unknown. In this study using zebrafish, we rep...
  9. Selective Manipulation of the Gut Microbiota Improves Immune Status in Vertebrates.

    Frontiers in Immunology 6:512 (2015) PMID 26500650 PMCID PMC4598590

    All animals develop in association with complex microbial communities. It is now well established that commensal microbiota is essential for the correct functionality of each organ in the host. Particularly, the commensal gastro-intestinal microbiota (CGIM) is a key factor for development, immun...
  10. Effects of recombinant flagellin B and its ND1 domain from Vibrio anguillarum on macrophages from gilthead seabream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss, W.).

    Fish & Shellfish Immunology 42(1):144 (2015) PMID 25449380

    Flagellin is the principal component of flagellum in Gram negative and positive bacteria, and it is also the ligand that activates the Toll-like receptor 5 (TLR5) in mammals and fish. In higher vertebrates, flagellin induces the activation of the membrane-bound TLR5 (TLR5M), which promotes the e...