1. Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis.

    International Journal of Cancer 139(8):1764 (2016) PMID 27273788

    Dysregulated bile acids (BAs) are closely associated with liver diseases and attributed to altered gut microbiota. Here, we show that the intrahepatic retention of hydrophobic BAs including deoxycholate (DCA), taurocholate (TCA), taurochenodeoxycholate (TCDCA), and taurolithocholate (TLCA) were ...
  2. Par3 regulates invasion of pancreatic cancer cells via interaction with Tiam1.

    Clinical and Experimental Medicine 16(3):357 (2016) PMID 26084985

    The conserved polarity complex, which comprises partitioning-defective proteins Par3, Par6, and the atypical protein kinase C, affects various cell-polarization events, including assembly of tight junctions. Control of tight junction assembly is closely related to invasion and migration potentia...
  3. Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.

    Antimicrobial Agents and Chemotherapy 60(8):5033 (2016) PMID 27216058 PMCID PMC4958199

    The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collecte...
  4. Histamine is correlated with liver fibrosis in biliary atresia.

    Digestive and Liver Disease 48(8):921 (2016) PMID 27257052

    Biliary atresia (BA) is a severe neonatal cholestasis disease that is caused by obstruction of extra bile ducts. Liver fibrosis progresses dramatically in BA, and the underlying molecular mechanism is largely unknown. Amino acids and biogenic amines were quantified by targeted metabolomic method...
  5. CO2 Accounting and Risk Analysis for CO2 Sequestration at Enhanced Oil Recovery Sites.

    Environmental Science & Technology 50(14):7546 (2016) PMID 27362472

    Using CO2 in enhanced oil recovery (CO2-EOR) is a promising technology for emissions management because CO2-EOR can dramatically reduce sequestration costs in the absence of emissions policies that include incentives for carbon capture and storage. This study develops a multiscale statistical fr...
  6. Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids.

    Analytical chemistry 88(14):7041 (2016) PMID 27322813

    Host-gut microbial interactions contribute to human health and disease states and an important manifestation resulting from this cometabolism is a vast diversity of bile acids (BAs). There is increasing interest in using BAs as biomarkers to assess the health status of individuals and, therefore...
  7. Global and Targeted Metabolomics Evidence of the Protective Effect of Chinese Patent Medicine Jinkui Shenqi Pill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats.

    Journal of Proteome Research 15(7):2327 (2016) PMID 27267777

    Glucocorticoids are commonly used in anti-inflammatory and immunomodulatory therapies, but glucocorticoid withdrawal can result in life-threatening risk of adrenal insufficiency. Chinese patented pharmaceutical product Jinkui Shenqi pill (JKSQ) has potent efficacy on clinical adrenal insufficien...
  8. Highly efficient reflective Dammann grating with a triangular structure.

    Applied Optics 55(19):5203 (2016) PMID 27409211

    A highly efficient reflective Dammann grating with a triangular structure operating at 1064 nm wavelength under normal incidence for TE polarization is designed and fabricated. Rigorous coupled wave analysis and particle swarm optimization algorithms are adopted to design and analyze the propert...
  9. Metabonomics Approach to Assessing the Metabolism Variation and Endoexogenous Metabolic Interaction of Ginsenosides in Cold Stress Rats.

    Journal of Proteome Research 15(6):1842 (2016) PMID 27150950

    Metabolic profiling technology, a massive information provider, has promoted the understanding of the metabolism of multicomponent medicines and its interactions with endogenous metabolites, which was previously a challenge in clarification. In this study, an untargeted GC/MS-based approach was ...
  10. Distinctly altered gut microbiota in the progression of liver disease.

    Oncotarget 7(15):19355 (2016) PMID 27036035

    Recent studies underscore important roles of intestinal microbiota and the bacterial lipopolysaccharides (LPS) production in the pathogenesis of liver disease. However, how gut microbiota alters in response to the development of steatosis and subsequent progression to nonalcoholic steatohepatiti...
  11. Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway.

    Journal of Proteome Research 15(4):1333 (2016) PMID 26956768 PMCID PMC4874490

    Metabolic profiling has great potential to help the diagnosis and prognosis of cancer patients. Fanconi Anemia (FA) tumor-suppressor signaling has been instrumental in understanding human tumorigenesis. However, this instrumental understanding has never been demonstrated at the metabolic level. ...
  12. MAP3K3 overexpression is associated with poor survival in ovarian carcinoma.

    Human Pathology 50:162 (2016) PMID 26997451

    Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is ubiquitously expressed in numerous tissues and is activated by various extracellular stimuli to regulate processes, such as cell proliferation and differentiation. Recent studies have identified potentially pathologic conditions of MAP...
  13. Comparison of tubularized incised plate urethroplasty combined with a meatus-based ventral dartos flap or dorsal dartos flap in hypospadias.

    Pediatric Surgery International 32(4):411 (2016) PMID 26783086

    Tubularized incised plate urethroplasty (TIPU) is the preferred surgical option for distal and mid-shaft hypospadias repair. Neourethra dartos flap coverage is routinely used as a protective layer with good results. We modified meatus-based ventral dartos flap (MBVDF) to TIPU by dissecting the p...
  14. Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced Cirrhosis.

    Journal of Proteome Research 15(4):1126 (2016) PMID 25964117

    Recent metabonomic studies have identified an important role of bile acids in patients with liver cirrhosis. Serum bile acids, such as glycocholate (GCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), and taurochenodeoxycholate (TCDCA), increased significantly in liver cirrhosis patients. ...
  15. Platinum-Copper Nanoframes: One-Pot Synthesis and Enhanced Electrocatalytic Activity.

    Chemistry: A European Journal 22(14):4960 (2016) PMID 26880582

    Platinum-copper nanoframes were produced from copper nanoparticles by a one-pot synthesis method. The growth mechanism was thoroughly studied by experiment and theoretical calculations. Owing to the unique structure, Pt-Cu nanoframes exhibited significantly enhanced catalytic activity toward the...
  16. Preparation of Substrate for Flavorant from Chicken Bone Residue with Hot-Pressure Process.

    Journal of Food Science 81(3):C578 (2016) PMID 26809140

    Hot-pressure extraction (HPE), which is regarded as a "green" technology, was applied to extract nutrients (protein, collagen, and minerals) from chicken bone residue (CBR). Amino acids (AA), color, and volatile flavor compounds of chicken bone extract (CBE) were also investigated. Results showe...
  17. Local line directional pattern for palmprint recognition

    Pattern Recognition 50:26 (2016)

    Local binary patterns (LBP) are one of the most important image representations. However, LBPs have not been as successful as other methods in palmprint recognition. Originally, the LBP descriptor methods construct feature vectors in the image intensity space, using pixel intensity dif...
  18. Colorimetric detection of Cu2+ by surface coordination complexes of polyethyleneimine-capped Au nanoparticles

    Sensors and Actuators B: Chemical 223:411 (2016)

    A new simple colorimetric chemosensor for sensitive and selective detection of Cu2+ using polyethyleneimine (PEI)-capped Au nanoparticles (PEI/Au NPs) has been developed. PEI/Au NPs are synthesized by using PEI as reducer without adding nanoparticles seeds and stabilizing agent. Copper...
  19. The influence of gut microbiota on drug metabolism and toxicity.

    Expert Opinion on Drug Metabolism and Toxicology 12(1):31 (2016) PMID 26569070

    Gut microbiota plays critical roles in drug metabolism. The variation of gut microbiota contributes to the interindividual differences toward drug therapy including drug-induced toxicity and efficacy. Accordingly, the investigation and elucidation of gut microbial impacts on drug metabolism and ...
  20. Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis.

    Genome Medicine 8(1):34 (2016) PMID 27036109 PMCID PMC4818393

    More accurate diagnostic methods are pressingly needed to diagnose breast cancer, the most common malignant cancer in women worldwide. Blood-based metabolomics is a promising diagnostic method for breast cancer. However, many metabolic biomarkers are difficult to replicate among studies. We prop...