Porous TiO2 Assembled from Monodispersed Nanoparticles.
Nanoscale Research Letters 11(1):159 (2016)
Porous TiO2 were assembled by evaporating or refluxing TiO2 colloid, which was obtained by dispersing the TiO2 nanoparticles with a crystallite size (d XRD) of 3.2 nm into water or ethanol without any additives. Porous transparent bulk TiO2 was obtained by evaporating the TiO2-C2H5OH colloid at ...
Tyrosine kinase inhibitor sunitinib therapy is effective in the treatment of bone metastasis from cancer of unknown primary: Identification of clinical and immunohistochemical biomarkers predicting survival.
International Journal of Cancer 139(6):1423 (2016)
Bone metastasis from cancer of unknown primary (BMCUP) brings poor survival prognosis and its management remains controversial. Sunitinib (SUTENT) proved effective in many sorts of solid tumors but has never been applied for patients with occult primary cancers, and there is no study to identify...
Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer.
Biomaterials 101:20 (2016)
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer for which there is no available targeted therapy. TNBC cases contribute disproportionately to breast cancer-related mortality, thus the need for novel and effective therapeutic methods is urgent. We have previously sh...
Two new triterpenoid saponins from ginseng medicinal fungal substance.
Journal of Asian Natural Products Research 18(9):865 (2016)
Two new dammarane-type triterpenoid saponins, namely ginsenosides Rb4 (1) and Rb5 (2), were isolated from ginseng medicinal fungal substance. The structures of 1 and 2 were established as 3β,12β,20(S)-trihydroxydammar-24(25)-ene-3-O-[α-d-glucopyranosyl-(1→4)-β-d-glucopyranosyl-(1→2)-β-d-glucopyr...
The risk of cancer in patients with connective tissue diseases but without dermatomyositis or polymyositis: A multicenter cohort study conducted over 15 years in China.
Immunology Letters 177:70 (2016)
To investigate the relative risk of cancer in Chinese patients with connective tissue diseases (CTD) associated with and without dermatomyositis or polymyositis.
A retrospective, multicenter cohort study investigated 32,380 CTD patients (2334 diagnosed with dermatomyositis or polymyositis) witho...
Critical factors determining fluoride concentration in tea leaves produced from Anhui province, China.
Ecotoxicology and Environmental Safety 131:14 (2016)
This study investigated the fluoride present in tea plants (Camellia sinensis (L.) O. Kuntze) and its relationship to soils, varieties, seasons and tea leaf maturity. The study also explored how different manufacturing processes affect the leaching of fluoride into tea beverages. The fluoride co...
Adjuvant effect of docetaxel on HPV16 L2E6E7 fusion protein vaccine in a mouse model.
International Immunopharmacology 38:16 (2016)
We previously demonstrated that the antineoplastic agent docetaxel enhanced the immune response to an influenza vaccine. This study evaluated the adjuvant effect of docetaxel (DOC) on the therapeutic efficacy of HPV16 L2E6E7 fusion protein (HPV-LFP) in mice inoculated with TC-1 cells. The result...
Dickkopf 2 promotes proliferation and invasion via Wnt signaling in prostate cancer.
Molecular Medicine Reports 14(3):2283 (2016)
Wnt/β-catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1‑4) has been shown to be important in the regulation of Wnt signaling. However, the functions and mechanism of DKK2 in the development and progression of pro...
Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma.
Head & Neck (Print Edition) 38(9):1347 (2016)
The prognostic significance of human papillomavirus (HPV) in the context of head and neck squamous cell carcinoma (HNSCC) of cancer of unknown primary (CUP) origin is unclear.
Patients treated for CUP at the Princess Margaret Cancer Centre between 2001 and 2013 were stratified by p16 status and ...
High throughput peptide mapping method for analysis of site specific monoclonal antibody oxidation.
Journal of chromatography. A 1460:51 (2016)
Oxidation of therapeutic monoclonal antibodies (mAbs) often occurs on surface exposed methionine and tryptophan residues during their production in cell culture, purification, and storage, and can potentially impact the binding to their targets. Characterization of site specific oxidation is cri...
Lateral actuation of an organic droplet on conjugated polymer electrodes via imbalanced interfacial tensions.
Soft Matter 12(33):6902 (2016)
This paper presents a new mechanism for the controlled lateral actuation of organic droplets on dodecylbenzenesulfonate-doped polypyrrole (PPy(DBS)) electrodes at low voltages (∼0.9 V) in an aqueous environment. The droplet actuation is based on the tunable surface wetting properties of the poly...
miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer.
JNCI Journal of the National Cancer Institute 108(8) (2016)
Brain metastasis poses a major treatment challenge and remains an unmet clinical need. Finding novel therapies to prevent and treat brain metastases requires an understanding of the biology and molecular basis of the process, which currently is constrained by a dearth of experimental models and ...
miR-126-3p and miR-451a correlate with clinicopathological features of lung adenocarcinoma: The underlying molecular mechanisms.
Oncology Reports 36(2):909 (2016)
Lung cancer is the most common malignancy worldwide. This study aimed to identify miRNA biomarkers of lung adenocarcinoma and to investigate their molecular mechanisms. miRNA expression profiling of tumor tissues and adjacent normal tissues from 10 patients were detected using microarray. Differ...
UV-C-Induced alleviation of transcriptional gene silencing through plant-plant communication: Key roles of jasmonic acid and salicylic acid pathways.
Plant stress responses at the epigenetic level are expected to allow more permanent changes of gene expression and potentially long-term adaptation. While it has been reported that plants subjected to adverse environments initiate various stress responses in their neighboring plants, little is k...
Targeting Estrogen Receptor Beta in a Phase 2 Study of High-Dose Estradiol in Metastatic Triple-Negative Breast Cancer: A Wisconsin Oncology Network Study.
Clinical Breast Cancer 16(4):256 (2016)
Estrogen receptor beta (ERβ) is expressed by 50% to 80% of triple-negative breast cancers (TNBC). Agonism of ERβ has antiproliferative effects in TNBC cells expressing ERβ. This phase 2 study evaluated single-agent high-dose estradiol in patients with advanced TNBC.
Adult women with measurable a...
Rapid determination of bacterial aminoglycoside resistance in environmental samples using membrane electrospray ionization mass spectrometry.
Rapid Communications in Mass Spectrometry 30 Suppl 1:202 (2016)
Antibiotic resistance in pathogenic bacteria is becoming a global public health problem, such as aminoglycoside resistance encoded by the armA gene. Although many methods have been reported, rapid analysis of environmental samples is still challenging.
A rapid analytical method was developed in ...
Improved immune response to an attenuated pseudorabies virus vaccine by ginseng stem-leaf saponins (GSLS) in combination with thimerosal (TS).
Antiviral Research 132:92 (2016)
Vaccination using attenuated vaccines remains an important method to control animal infectious diseases. The present study evaluated ginseng stem-leaf saponins (GSLS) and thimerosal (TS) for their adjuvant effect on an attenuated pseudorabies virus (aPrV) vaccine in mice. Compared to the group i...
Dehalogenative Homocoupling of Terminal Alkynyl Bromides on Au(111): Incorporation of Acetylenic Scaffolding into Surface Nanostructures.
ACS Nano 10(7):7023 (2016)
On-surface C-C coupling reactions of molecular precursors with alkynyl functional groups demonstrate great potential for the controllable fabrication of low-dimensional carbon nanostructures/nanomaterials, such as carbyne, graphyne, and graphdiyne, which demand the incorporation of highly active...
Is There Consistency between the Binding Affinity and Inhibitory Potential of Natural Polyphenols as α-amylase Inhibitors?
Critical Reviews in Food Science and Nutrition 56(10):1630 (2016)
The inhibitory potential of natural polyphenols for α-amylases has attracted great interests among researchers. The structure-affinity properties of natural polyphenols binding to α-amylase and the structure-activity relationship of dietary polyphenols inhibiting α-amylase were deeply investigat...
Long Cyclic Life in Manganese Oxide-Based Electrodes.
ACS Applied Materials & Interfaces 8(28):18078 (2016)
Long cyclic life is very important to the practical application of the pseudocapacitors. A systematic study has been carried out to reveal what key factors and how they affecting the cycling behaviors of manganese oxides. The specific capacitance degradation of MnOx is usually attributed to the ...