1. Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING.

    Journal of Biological Chemistry 290(30):18400 (2015) PMID 25979331 PMCID PMC4513101

    People with Rett syndrome and mouse models show autonomic dysfunction involving the brain stem locus coeruleus (LC). Neurons in the LC of Mecp2-null mice are overly excited, likely resulting from a defect in neuronal intrinsic membrane properties and a deficiency in GABA synaptic inhibition. In ...
  2. Multi-endpoint, High-Throughput Study of Nanomaterial Toxicity in Caenorhabditis elegans.

    Environmental Science & Technology 49(4):2477 (2015) PMID 25611253

    The booming nanotechnology industry has raised public concerns about the environmental health and safety impact of engineered nanomaterials (ENMs). High-throughput assays are needed to obtain toxicity data for the rapidly increasing number of ENMs. Here we present a suite of high-throughput meth...
  3. Multi-endpoint, High-Throughput Study of Nanomaterial Toxicity in Caenorhabditis elegans.

    Environmental Science & Technology 49(4):2477 (2015) PMID 25611253 PMCID PMC4336152

    The booming nanotechnology industry has raised public concerns about the environmental health and safety impact of engineered nanomaterials (ENMs). High-throughput assays are needed to obtain toxicity data for the rapidly increasing number of ENMs. Here we present a suite of high-throughput meth...
  4. Multi-endpoint, High-Throughput Study of Nanomaterial Toxicity in Caenorhabditis elegans.

    Environmental Science & Technology 49(4):2477 (2015) PMID 25611253 PMCID PMC4336152

    The booming nanotechnology industry has raised public concerns about the environmental health and safety impact of engineered nanomaterials (ENMs). High-throughput assays are needed to obtain toxicity data for the rapidly increasing number of ENMs. Here we present a suite of high-throughput meth...
  5. Multi-endpoint, High-Throughput Study of Nanomaterial Toxicity in Caenorhabditis elegans.

    Environmental Science & Technology 49(4):2477 (2015) PMID 25611253

    The booming nanotechnology industry has raised public concerns about the environmental health and safety impact of engineered nanomaterials (ENMs). High-throughput assays are needed to obtain toxicity data for the rapidly increasing number of ENMs. Here we present a suite of high-throughput meth...
  6. An automated system for quantitative analysis of Drosophila larval locomotion.

    BMC Developmental Biology 15(1):11 (2015) PMID 25881248 PMCID PMC4345013

    Drosophila larvae have been used as a model to study to genetic and cellular circuitries modulating behaviors. One of the challenges in behavioral study is the quantification of complex phenotypes such as locomotive behaviors. Experimental capability can be greatly enhanced by an automatic singl...
  7. Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans.

    Environmental Toxicology and Chemistry 33(12):2716 (2014) PMID 25088842 PMCID PMC4331122

    The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at l...
  8. Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans.

    Environmental Toxicology and Chemistry 33(12):2716 (2014) PMID 25088842 PMCID PMC4331122

    The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at l...
  9. Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans.

    Environmental Toxicology and Chemistry 33(12):2716 (2014) PMID 25088842

    The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at l...
  10. Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans.

    Environmental Toxicology and Chemistry 33(12):2716 (2014) PMID 25088842

    The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at l...
  11. Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans.

    Environmental Toxicology and Chemistry 33(12):2716 (2014) PMID 25088842

    The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at l...
  12. Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome.

    American Journal of Physiology - Cell Physiology 307(6):C508 (2014) PMID 25009110 PMCID PMC4166737

    Rett syndrome is an autism-spectrum disorder resulting from mutations to the X-linked gene, methyl-CpG binding protein 2 (MeCP2), which causes abnormalities in many systems. It is possible that the body may develop certain compensatory mechanisms to alleviate the abnormalities. The norepinephrin...
  13. Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome.

    American Journal of Physiology - Cell Physiology 307(6):C508 (2014) PMID 25009110 PMCID PMC4166737

    Rett syndrome is an autism-spectrum disorder resulting from mutations to the X-linked gene, methyl-CpG binding protein 2 (MeCP2), which causes abnormalities in many systems. It is possible that the body may develop certain compensatory mechanisms to alleviate the abnormalities. The norepinephrin...
  14. Crystal structure of a nematode-infecting virus.

    PNAS 111(35):12781 (2014) PMID 25136116 PMCID PMC4156749

    Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses show that Orsay is related to nodaviruses, but molecular characterizations of Orsay reveal several unique features, such as the expression o...
  15. Crystal structure of a nematode-infecting virus.

    PNAS 111(35):12781 (2014) PMID 25136116 PMCID PMC4156749

    Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses show that Orsay is related to nodaviruses, but molecular characterizations of Orsay reveal several unique features, such as the expression o...
  16. Crystal structure of a nematode-infecting virus.

    PNAS 111(35):12781 (2014) PMID 25136116 PMCID PMC4156749

    Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses show that Orsay is related to nodaviruses, but molecular characterizations of Orsay reveal several unique features, such as the expression o...
  17. Crystal structure of a nematode-infecting virus.

    PNAS 111(35):12781 (2014) PMID 25136116 PMCID PMC4156749

    Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses show that Orsay is related to nodaviruses, but molecular characterizations of Orsay reveal several unique features, such as the expression o...
  18. Crystal structure of a nematode-infecting virus.

    PNAS 111(35):12781 (2014) PMID 25136116 PMCID PMC4156749

    Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses show that Orsay is related to nodaviruses, but molecular characterizations of Orsay reveal several unique features, such as the expression o...
  19. Crystal structure of a nematode-infecting virus.

    PNAS 111(35):12781 (2014) PMID 25136116 PMCID PMC4156749

    Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses show that Orsay is related to nodaviruses, but molecular characterizations of Orsay reveal several unique features, such as the expression o...
  20. Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression.

    Molecular and Cellular Biochemistry 389(1-2):151 (2014) PMID 24390087

    The molecular mechanisms of impaired liver regeneration in several liver diseases remain poorly understood. Endoplasmic reticulum (ER) stress has been observed in a variety of liver diseases. The aims of this study were to explore the impacts of ER stress on hepatocyte growth factor (HGF)-induce...