1. Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

    Journal of Biological Chemistry 284(36):24394 (2009) PMID 19535340 PMCID PMC2782032

    SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat...
  2. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

    Protein Science 18(3):514 (2009) PMID 19241369 PMCID PMC2760358

    SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about its actual size, the sequences required for activity, and its subcellular localization. A previously cloned mouse SIRT3 has high sequenc...
  3. Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors.

    Bioorganic & Medicinal Chemistry Letters 19(5):1416 (2009) PMID 19181526

    A series of triamide derivatives bearing a benzothiazole core is shown to be potent microsomal triglyceride transfer protein (MTP) inhibitors. In order to minimize liver toxicity, these compounds have been optimized to have activity only in the enterocytes and have limited systemic bioavailabili...
  4. Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors

    Bioorganic & Medicinal Chemistry Letters 19(5):1416 (2009)

    A series of benzothiazole derivatives is shown to be potent MTP inhibitors, with some showing oral activity in a mice diet-induced obesity model.
  5. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

    Nature 450(7170):712 (2007) PMID 18046409 PMCID PMC2753457

    Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeost...
  6. Fabry disease in mice protects against lethal disease caused by Shiga toxin-expressing enterohemorrhagic Escherichia coli.

    Journal of Infectious Diseases 194(8):1135 (2006) PMID 16991089

    Fabry disease is an X-linked recessive disorder in which affected persons lack alpha-galactosidase A (alpha -GalA), which leads to excess glycosphingolipids in tissues, mainly globotriaosylceramide (Gb3). Gb3 is the cellular receptor for Shiga toxin (Stx), the primary virulence factor of enteroh...
  7. Delivery of heterologous protein antigens via hemolysin or autotransporter systems by an attenuated ler mutant of rabbit enteropathogenic Escherichia coli.

    Vaccine 24(18):3821 (2006) PMID 16098637

    In this report, we describe the use of an attenuated regulatory mutant of a rabbit enteropathogenic Escherichia coli (rEPEC) as a live vaccine vector to deliver heterologous protein antigens using two dedicated transport systems, a Salmonella autotransporter and the E. coli hemolysin apparatus. ...
  8. Delivery of heterologous protein antigens via hemolysin or autotransporter systems by an attenuatedlermutant of rabbit enteropathogenicEscherichia coli

    Vaccine 24(18):3821 (2006)

    In this report, we describe the use of an attenuated regulatory mutant of a rabbit enteropathogenic Escherichia coli (rEPEC) as a live vaccine vector to deliver heterologous protein antigens using two dedicated transport systems, a Salmonella autotransporter and the E. ...