1. Mass cytometry analysis shows that a novel memory phenotype B cell is expanded in multiple myeloma.

    Cancer Immunology Research 3(6):650 (2015) PMID 25711758 PMCID PMC4457663

    It would be very beneficial if the status of cancers could be determined from a blood specimen. However, peripheral blood leukocytes are very heterogeneous between individuals, and thus high-resolution technologies are likely required. We used cytometry by time-of-flight and next-generation sequ...
  2. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.

    Annals of the Rheumatic Diseases 74(3):579 (2015) PMID 24297382

    A hallmark of rheumatoid arthritis (RA) is the development of autoantibodies targeting proteins that contain citrulline. Anticitrullinated protein antibodies (ACPAs) are currently detected by the commercial cyclic citrullinated peptide (CCP) assay, which uses a mix of cyclised citrullinated pept...
  3. Sequencing the functional antibody repertoire--diagnostic and therapeutic discovery.

    Nature Reviews: Rheumatology 11(3):171 (2015) PMID 25536486 PMCID PMC4382308

    The development of high-throughput DNA sequencing technologies has enabled large-scale characterization of functional antibody repertoires, a new method of understanding protective and pathogenic immune responses. Important parameters to consider when sequencing antibody repertoires include the ...
  4. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.

    Annals of the Rheumatic Diseases 74(3):579 (2015) PMID 24297382 PMCID PMC4345988

    A hallmark of rheumatoid arthritis (RA) is the development of autoantibodies targeting proteins that contain citrulline. Anticitrullinated protein antibodies (ACPAs) are currently detected by the commercial cyclic citrullinated peptide (CCP) assay, which uses a mix of cyclised citrullinated pept...
  5. Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis.

    Arthritis & rheumatology (Hoboken, N.J.) 67(3):645 (2015) PMID 25417811

    Malondialdehyde-acetaldehyde (MAA) adducts are a product of oxidative stress associated with tolerance loss in several disease states. This study was undertaken to investigate the presence of MAA adducts and circulating anti-MAA antibodies in patients with rheumatoid arthritis (RA). Synovial tis...
  6. Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis.

    Arthritis & rheumatology (Hoboken, N.J.) 67(3):645 (2015) PMID 25417811

    Malondialdehyde-acetaldehyde (MAA) adducts are a product of oxidative stress associated with tolerance loss in several disease states. This study was undertaken to investigate the presence of MAA adducts and circulating anti-MAA antibodies in patients with rheumatoid arthritis (RA). Synovial tis...
  7. Alveolar Bone Loss Is Associated With Circulating Anti-Citrullinated Protein Antibody (ACPA) in Patients With Rheumatoid Arthritis.

    Journal of Periodontology 86(2):222 (2015) PMID 25299390

    This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentration...
  8. Alveolar Bone Loss Is Associated With Circulating Anti-Citrullinated Protein Antibody (ACPA) in Patients With Rheumatoid Arthritis.

    Journal of Periodontology 86(2):222 (2015) PMID 25299390

    This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentration...
  9. Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis.

    Arthritis & rheumatology (Hoboken, N.J.) 66(10):2706 (2014) PMID 24965753

    A hallmark of rheumatoid arthritis (RA) is the production of autoantibodies, including anti-citrullinated protein antibodies (ACPAs). Nevertheless, the specific targets of these autoantibodies remain incompletely defined. During an immune response, B cells specific for the inciting antigen(s) ar...
  10. Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis.

    Arthritis & rheumatology (Hoboken, N.J.) 66(10):2793 (2014) PMID 24980965 PMCID PMC4198528

    Although ankylosing spondylitis (AS) is driven by immune-mediated processes, little is known about the presence and role of autoantibodies in this disease. This study was undertaken to investigate whether autoantibodies occur in and are involved in AS. We performed human protein microarray analy...
  11. Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.

    Arthritis & rheumatology (Hoboken, N.J.) 66(10):2881 (2014) PMID 24943488 PMCID PMC4443497

    Gouty arthritis is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints. While it has been reported that mast cells (MCs) infiltrate gouty tophi, little is known about the actual roles of MCs during acute attacks of gout. This study was undertaken to assess th...
  12. Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.

    Arthritis & rheumatology (Hoboken, N.J.) 66(10):2881 (2014) PMID 24943488

    Gouty arthritis is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints. While it has been reported that mast cells (MCs) infiltrate gouty tophi, little is known about the actual roles of MCs during acute attacks of gout. This study was undertaken to assess th...
  13. Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis.

    Arthritis & rheumatology (Hoboken, N.J.) 66(10):2706 (2014) PMID 24965753

    A hallmark of rheumatoid arthritis (RA) is the production of autoantibodies, including anti-citrullinated protein antibodies (ACPAs). Nevertheless, the specific targets of these autoantibodies remain incompletely defined. During an immune response, B cells specific for the inciting antigen(s) ar...
  14. Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis.

    Arthritis & rheumatology (Hoboken, N.J.) 66(10):2793 (2014) PMID 24980965 PMCID PMC4198528

    Although ankylosing spondylitis (AS) is driven by immune-mediated processes, little is known about the presence and role of autoantibodies in this disease. This study was undertaken to investigate whether autoantibodies occur in and are involved in AS. We performed human protein microarray analy...
  15. Reply: To PMID 24497204.

    Arthritis & rheumatology (Hoboken, N.J.) 66(9):2644 (2014) PMID 24891318

  16. Reply: To PMID 24497204.

    Arthritis & rheumatology (Hoboken, N.J.) 66(9):2644 (2014) PMID 24891318

  17. Reply: To PMID 24497204.

    Arthritis & rheumatology (Hoboken, N.J.) 66(9):2644 (2014) PMID 24891318

  18. Street-experienced peripheral B cells traffic to the brain.

    Science Translational Medicine 6(248):248fs31 (2014) PMID 25100737

    Deep sequencing of immunoglobulin repertoires in multiple sclerosis patients reveals dysregulation of peripheral B cell immunity (Palanichamy et al. and Stern et al., this issue). Copyright © 2014, American Association for the Advancement of Science.
  19. Street-experienced peripheral B cells traffic to the brain.

    Science Translational Medicine 6(248):248fs31 (2014) PMID 25100737 PMCID PMC4382305

    Deep sequencing of immunoglobulin repertoires in multiple sclerosis patients reveals dysregulation of peripheral B cell immunity (Palanichamy et al. and Stern et al., this issue). Copyright © 2014, American Association for the Advancement of Science.
  20. Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease.

    Annals of the Rheumatic Diseases 73(8):1487 (2014) PMID 23716070 PMCID PMC3883892

    Interstitial lung disease (ILD) is associated with high morbidity and mortality in rheumatoid arthritis (RA). Citrullinated proteins are observed in RA lung tissues; however, the association of specific anticitrullinated peptide antibodies (ACPA) with ILD in RA is unknown. RA patients underwent ...