1. Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome.

    Journal of Autoimmunity 60:59 (2015) PMID 25975491 PMCID PMC4459730

    Rheumatoid arthritis (RA) remains a debilitating autoimmune condition as many patients are refractory to existing conventional and biologic therapies, and hence successful development of novel treatments remains a critical requirement. Towards this, we now describe a synthetic drug-like small mo...
  2. The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice.

    Arthritis & rheumatology (Hoboken, N.J.) 67(4):1023 (2015) PMID 25546822 PMCID PMC4409857

    The hygiene hypothesis suggests that parasitic helminths (worms) protect against the development of autoimmune disease via a serendipitous side effect of worm-derived immunomodulators that concomitantly promote parasite survival and limit host pathology. The aim of this study was to investigate ...
  3. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model

    International Journal for Parasitology 45(4):203 (2015)

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  4. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model

    International Journal for Parasitology 45(4):203 (2015) PMID 25666929 PMCID PMC4355381

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  5. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.

    International Journal for Parasitology 45(4):203 (2015) PMID 25666929

    ES-62 is an anti-inflammatory phosphorylcholine-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae. Accelerated atherosclerosis frequently occurs in systemic lupus erythematosus, resulting in substantial cardiovascular morbidity and mortality. We examined the effe...
  6. Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties.

    International Journal for Parasitology 44(9):669 (2014) PMID 24929132 PMCID PMC4119935

    ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds...
  7. Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties.

    International Journal for Parasitology 44(9):669 (2014) PMID 24929132 PMCID PMC4119935

    ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds...
  8. Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties.

    International Journal for Parasitology 44(9):669 (2014) PMID 24929132 PMCID PMC4119935

    ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds...
  9. Secretory products of helminth parasites as immunomodulators.

    Molecular and Biochemical Parasitology 195(2):130 (2014) PMID 24704440

    Parasitic helminths release molecules into their environment, which are generally referred to as excretory-secretory products or ES. ES derived from a wide range of nematodes, trematodes and cestodes have been studied during the past 30-40 years, their characterization evolving from simple bioch...
  10. Secretory products of helminth parasites as immunomodulators

    Molecular and Biochemical Parasitology 195(2):130 (2014)

    Secretory products of helminth parasites modulate the activities of a number of cells of the immune system, blocking pro-inflammatory/Th1/Th17 responses and inducing anti-inflammatory/Th2 responses.
  11. ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints.

    Arthritis & rheumatology (Hoboken, N.J.) 66(6):1492 (2014) PMID 24497523

    The parasitic worm-derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17-associated cytokine IL-22 also appears to have a pathogenic role in auto...
  12. ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints.

    Arthritis & rheumatology (Hoboken, N.J.) 66(6):1492 (2014) PMID 24497523

    The parasitic worm-derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17-associated cytokine IL-22 also appears to have a pathogenic role in auto...
  13. ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae

    Molecular and Biochemical Parasitology 194(1-2):1 (2014)

  14. Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints.

    Immunology 141(3):457 (2014) PMID 24708419 PMCID PMC3930382

    We have previously reported that ES-62, a molecule secreted by the parasitic filarial nematode Acanthocheilonema viteae, protects mice from developing collagen-induced arthritis (CIA). Together with increasing evidence that worm infection may protect against autoimmune conditions, this raises th...
  15. Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints.

    Immunology 141(3):457 (2014) PMID 24708419 PMCID PMC3930382

    We have previously reported that ES-62, a molecule secreted by the parasitic filarial nematode Acanthocheilonema viteae, protects mice from developing collagen-induced arthritis (CIA). Together with increasing evidence that worm infection may protect against autoimmune conditions, this raises th...
  16. Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

    Journal of medicinal and pharmaceutical chemistry 56(24):9982 (2013) PMID 24228757 PMCID PMC4125414

    In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We h...
  17. Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

    Journal of medicinal and pharmaceutical chemistry 56(24):9982 (2013) PMID 24228757 PMCID PMC4125414

    In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We h...
  18. Reply: To PMID 22729944.

    Arthritis & Rheumatism 65(5):1403 (2013) PMID 23401057

  19. Reply: To PMID 22729944.

    Arthritis & Rheumatism 65(5):1403 (2013) PMID 23401057

  20. The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.

    International Journal for Parasitology 43(3-4):211 (2013) PMID 23291461 PMCID PMC3584281

    We previously demonstrated inhibition of ovalbumin-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae. This inhibition correlated with ES-62-induced mast cell desensitisati...