1. Patients' and clinicians' experiences of holistic needs assessment using a cancer distress thermometer and problem list: A qualitative study.

    European Journal of Oncology Nursing 23:59 (2016) PMID 27456376

    Psychosocial needs assessment is recommended for patients undergoing cancer treatment, but trials of effectiveness of assessment tools provide mixed results. This qualitative study aimed to understand how such tools are experienced by patients and clinicians in order to optimise use in the futur...
  2. Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis.

    The lancet psychiatry 3(8):730 (2016) PMID 27318812 PMCID PMC4967667

    Several interventions are available for management of obsessive-compulsive disorder in adults, but few studies have compared their relative efficacy in a single analysis. We aimed to simultaneously compare all available treatments using both direct and indirect data. In this systematic review an...
  3. The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

    Health technology assessment (Winchester, England) 20(51):1 (2016) PMID 27401902 PMCID PMC4958930

    It is not clear which young children presenting acutely unwell to primary care should be investigated for urinary tract infection (UTI) and whether or not dipstick testing should be used to inform antibiotic treatment. To develop algorithms to accurately identify pre-school children in whom urin...
  4. Nappy pad urine samples for investigation and treatment of UTI in young children: the 'DUTY' prospective diagnostic cohort study.

    British Journal of General Practice 66(648):e516 (2016) PMID 27364678 PMCID PMC4917055

    The added diagnostic utility of nappy pad urine samples and the proportion that are contaminated is unknown. To develop a clinical prediction rule for the diagnosis of urinary tract infection (UTI) based on sampling using the nappy pad method. Acutely unwell children <5 years presenting to 233 U...
  5. Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study.

    Annals of Family Medicine 14(4):325 (2016) PMID 27401420 PMCID PMC4940462

    Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. Our aim was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for u...
  6. A systematic review of the clinical effectiveness and cost-effectiveness of pharmacological and psychological interventions for the management of obsessive-compulsive disorder in children/adolescents and adults.

    Health technology assessment (Winchester, England) 20(43):1 (2016) PMID 27306503 PMCID PMC4921795

    Obsessive-compulsive disorder (OCD) is a relatively common and disabling condition. To determine the clinical effectiveness, acceptability and cost-effectiveness of pharmacological and psychological interventions for the treatment of OCD in children, adolescents and adults. We searched the Cochr...
  7. The feasibility of a randomised controlled trial of physiotherapy for adults with joint hypermobility syndrome.

    Health technology assessment (Winchester, England) 20(47):1 (2016) PMID 27365226 PMCID PMC4947876

    Joint hypermobility syndrome (JHS) is a heritable disorder associated with laxity and pain in multiple joints. Physiotherapy is the mainstay of treatment, but there is little research investigating its clinical effectiveness. To develop a comprehensive physiotherapy intervention for adults with ...
  8. Mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (MIR trial): study protocol for a randomised controlled trial.

    Trials 17(1):66 (2016) PMID 26842107

    People with depression are usually managed in primary care and antidepressants are often the first-line treatment, but only one third of patients respond fully to a single antidepressant. This paper describes the protocol for a randomised controlled trial (MIR) to investigate the extent to which...
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  9. A time-series study of percutaneous closure of patent foramen ovale: premature adoption?

    Open Heart 3(1):e000313 (2016) PMID 26835140 PMCID PMC4716454

    To evaluate the impact of National Institute for Health and Care Excellence (NICE) guidance in January 2005 and subsequent trial evidence on the adoption of percutaneous closure of patent foramen ovale (PCPFO). A retrospective time series study was conducted using the Inpatient Hospital Episode ...
  10. The Reporting of Treatment Nonadherence and Its Associated Impact on Economic Evaluations Conducted Alongside Randomized Trials: A Systematic Review.

    Value in Health 19(1):99 (2016) PMID 26797242

    To review trial-based economic evaluations, identifying 1) the proportion reporting adherence, 2) methods for assigning intervention costs according to adherence, 3) which participants were included in the economic analysis, and 4) statistical methods to estimate cost-effectiveness in those who ...
  11. The choice between hip prosthetic bearing surfaces in total hip replacement: a protocol for a systematic review and network meta-analysis.

    Systematic Reviews 5(1):19 (2016) PMID 26831503 PMCID PMC4736145

    Prosthetic hip implants have many combinations of bearing surface materials, sizes, and fixation techniques, which can determine the quality of life of patients after primary total hip replacement (THR) and the likelihood of needing revision surgery. When an implant fails, patients require revis...
  12. Hepatitis C - Assessment to Treatment Trial (HepCATT) in primary care: study protocol for a cluster randomised controlled trial.

    Trials 17:366 (2016) PMID 27473371 PMCID PMC4966763

    Public Health England (PHE) estimates that there are upwards of 160,000 individuals in England and Wales with chronic hepatitis C virus (HCV) infection, but until now only around 100,000 laboratory diagnoses have been reported to PHE and of these 28,000 have been treated. Targeted case-finding i...
  13. Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol.

    BMJ Open 6(7):e011255 (2016) PMID 27377634 PMCID PMC4947787

    Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evi...
  14. Characteristics of people dying by suicide after job loss, financial difficulties and other economic stressors during a period of recession (2010-2011): A review of coroners׳ records.

    Journal of Affective Disorders 183:98 (2015) PMID 26001669

    Suicide rates increase during periods of economic recession, but little is known about the characteristics of people whose deaths are related to recession, the timing of risk in relation to job loss, the nature of financial stresses and the sources of help individuals used. We extracted informat...
  15. Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery.

    British Journal of General Practice 65(633):e217 (2015) PMID 25824181 PMCID PMC4377600

    The prevalence of targeted and serendipitous treatment for, and associated recovery from, urinary tract infection (UTI) in pre-school children is unknown. To determine the frequency and suspicion of UTI in children who are acutely ill, along with details of antibiotic prescribing, its appropriat...
  16. "I won't call it rationing...": an ethnographic study of healthcare disinvestment in theory and practice.

    Social Science & Medicine 128:273 (2015) PMID 25635374

    Healthcare decision-makers have always faced the challenge of allocating finite resources, but the global economic downturn places extra pressure on health systems to meet rising demands. The National Institute for Health and Care Excellence (NICE) and UK government have therefore called on comm...
  17. Study protocol: the effectiveness and cost effectiveness of an employer-led intervention to increase walking during the daily commute: the Travel to Work randomised controlled trial.

    BMC Public Health 15(1):154 (2015) PMID 25884986 PMCID PMC4339476

    Physical inactivity increases the risk of many chronic diseases including coronary heart disease, type 2 diabetes and some cancers. It is recommended that adults should undertake at least 150 minutes of moderate intensity physical activity throughout the week but many adults do not achieve this....
  18. A systematic review of the magnitude and cause of geographic variation in unplanned hospital admission rates and length of stay for ambulatory care sensitive conditions.

    BMC Health Services Research 15:324 (2015) PMID 26268576 PMCID PMC4535775

    Unplanned hospital admissions place a large and increasing strain on healthcare budgets worldwide. Many admissions for ambulatory care sensitive conditions (ACSCs) are thought to be preventable, a belief supported by significant geographic variations in admission rates. We conducted a systematic...
  19. A systematic review of geographical variation in access to chemotherapy.

    BMC Cancer 16(1):1 (2015) PMID 26721515 PMCID PMC4697930

    Rising cancer incidence, the cost of cancer pharmaceuticals and the introduction of the Cancer Drugs Fund in England, but not other United Kingdom(UK) countries means evidence of 'postcode prescribing' in cancer is important. There have been no systematic reviews considering access to cancer dru...
  20. Methodological developments in randomized controlled trial-based economic evaluations.

    Expert Review of Pharmacoeconomics & Outcomes R... 14(6):843 (2014) PMID 25179207

    Economic evaluation is a key contributor to decision making in health care, and it is important that it is carried out as effectively and reliably as possible. Studies carried out alongside randomised controlled trials are required to contribute real-world evidence to the decision-making process...