1. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.

    Nature Communications 6:7339 (2015) PMID 26081744

    Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia caused by loss-of-function mutations in the low...
  2. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.

    Lipids 49(6):505 (2014) PMID 24777581

    Hepatic lipase (HL) and endothelial lipase (EL) share overlapping and complementary roles in lipoprotein metabolism. The deletion of HL and EL alleles in mice raises plasma total cholesterol and phospholipid concentrations. However, the influence of HL and EL in vivo on individual molecular spec...
  3. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.

    Lipids 49(6):505 (2014) PMID 24777581

    Hepatic lipase (HL) and endothelial lipase (EL) share overlapping and complementary roles in lipoprotein metabolism. The deletion of HL and EL alleles in mice raises plasma total cholesterol and phospholipid concentrations. However, the influence of HL and EL in vivo on individual molecular spec...
  4. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.

    Lipids 49(6):505 (2014) PMID 24777581

    Hepatic lipase (HL) and endothelial lipase (EL) share overlapping and complementary roles in lipoprotein metabolism. The deletion of HL and EL alleles in mice raises plasma total cholesterol and phospholipid concentrations. However, the influence of HL and EL in vivo on individual molecular spec...
  5. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.

    Atherosclerosis 233(1):234 (2014) PMID 24529150 PMCID PMC3936605

    Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL fractions of human serum. We sought to test the hypothesis that ApoF plays an important role in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed in male low density lipop...
  6. Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism.

    Methods in Molecular Biology 1027:273 (2013) PMID 23912992

    Adeno-associated viral vectors have proven to be excellent gene delivery vehicles for somatic overexpression. These viral vectors can efficiently and selectively target the liver, which plays a central role in lipoprotein metabolism. Both liver-expressed as well as non-hepatic secreted proteins ...
  7. Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism.

    Methods in Molecular Biology 1027:273 (2013) PMID 23912992

    Adeno-associated viral vectors have proven to be excellent gene delivery vehicles for somatic overexpression. These viral vectors can efficiently and selectively target the liver, which plays a central role in lipoprotein metabolism. Both liver-expressed as well as non-hepatic secreted proteins ...
  8. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.

    PLoS ONE 7(2):e31616 (2012) PMID 22363685 PMCID PMC3282742

    Apolipoprotein F (apoF) is 29 kilodalton secreted sialoglycoprotein that resides on the HDL and LDL fractions of human plasma. Human ApoF is also known as Lipid Transfer Inhibitor protein (LTIP) based on its ability to inhibit cholesteryl ester transfer protein (CETP)-mediated transfer events be...
  9. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.

    PLoS ONE 7(2):e31616 (2012) PMID 22363685 PMCID PMC3282742

    Apolipoprotein F (apoF) is 29 kilodalton secreted sialoglycoprotein that resides on the HDL and LDL fractions of human plasma. Human ApoF is also known as Lipid Transfer Inhibitor protein (LTIP) based on its ability to inhibit cholesteryl ester transfer protein (CETP)-mediated transfer events be...
  10. Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter

    Atherosclerosis 218(1):77 (2011)

    Objective The goal of this study was to examine the effects of thyroid hormone status on the ability of serum to accept cellular cholesterol.
  11. Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter.

    Atherosclerosis 218(1):77 (2011) PMID 21605865 PMCID PMC3324859

    The goal of this study was to examine the effects of thyroid hormone status on the ability of serum to accept cellular cholesterol. Sera from hypophysectomized rats treated ± T(3) was used to evaluate the role of thyroid hormone on serum efflux capacity. 2D-DIGE analysis of serum proteins showed...
  12. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.

    Biochimica et Biophysica Acta 1811(4):294 (2011) PMID 21296681

    Apolipoprotein (apo) O is a newly discovered apolipoprotein preferentially contained within HDL; however, currently, no data are available on the (patho)physiological effects of apoO. Therefore, the present study assessed the impact of apoO overexpression on (i) plasma lipids and lipoproteins as...
  13. Phospholipidation of HDL--how much is too much?

    Clinical Chemistry 57(1):4 (2011) PMID 21078838

  14. Phospholipidation of HDL--how much is too much?

    Clinical Chemistry 57(1):4 (2011) PMID 21078838

  15. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice

    Biochimica et Biophysica Acta (BBA) - Molecular... 1811(4):294 (2011)

    Apolipoprotein (apo) O is a newly discovered apolipoprotein preferentially contained within HDL; however, currently, no data are available on the (patho)physiological effects of apoO. Therefore, the present study assessed the impact of apoO overexpression on (i) plasma lipids and lipoprotei...
  16. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.

    Journal of Clinical Investigation 120(12):4410 (2010) PMID 21084752 PMCID PMC2993600

    Recent genome-wide association studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated with lower levels of plasma triglyceride (TG) and LDL cholesterol (LDL-C), higher levels of HDL-C, as well as decreased risk for myocardial infarction. This locus co...
  17. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.

    Journal of Clinical Investigation 120(12):4410 (2010) PMID 21084752 PMCID PMC2993600

    Recent genome-wide association studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated with lower levels of plasma triglyceride (TG) and LDL cholesterol (LDL-C), higher levels of HDL-C, as well as decreased risk for myocardial infarction. This locus co...
  18. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.

    Circulation Research 107(3):357 (2010) PMID 20558822 PMCID PMC2948973

    Hepatic lipase (HL) and endothelial lipase (EL) are extracellular lipases that both hydrolyze triglycerides and phospholipids and display potentially overlapping or complementary roles in lipoprotein metabolism. We sought to dissect the overlapping roles of HL and EL by generating mice deficient...
  19. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.

    Circulation Research 107(3):357 (2010) PMID 20558822 PMCID PMC2948973

    Hepatic lipase (HL) and endothelial lipase (EL) are extracellular lipases that both hydrolyze triglycerides and phospholipids and display potentially overlapping or complementary roles in lipoprotein metabolism. We sought to dissect the overlapping roles of HL and EL by generating mice deficient...
  20. Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.

    Arteriosclerosis, Thrombosis, and Vascular Biology 29(6):870 (2009) PMID 19325143 PMCID PMC2845307

    Recent proteomic studies have identified multiple proteins that coisolate with human HDL. We hypothesized that distinct clusters of protein components may distinguish between physicochemically-defined subpopulations of HDL particles, and that such clusters may exert specific biological function(...