1. Successful Concomitant Therapy with Pirfenidone and Nintedanib in Idiopathic Pulmonary Fibrosis: A Case Report.

    Respiration 91(4):327 (2016) PMID 27073887

    Pirfenidone and nintedanib are both pleiotropic anti-fibrotic agents approved for the treatment of idiopathic pulmonary fibrosis (IPF) as monotherapy. To date, evidence supporting their efficacy as concomitant therapy has not been reported. Here, we present the first case of a Caucasian male pat...
  2. [Severe Asthma].

    Deutsche Medizinische Wochenschrift 140(20):1524 (2015) PMID 26445257

    The European Respiratory Society and the American Thoracic Society recently published the international ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. It is aim of the guideline to establish standardized diagnostic criteria and to develop evidence based diagnostic a...
  3. Hot Topics in Noninvasive Ventilation: Report of a Working Group at the International Symposium on Sleep-Disordered Breathing in Leuven, Belgium.

    Respiratory care 60(9):1337 (2015) PMID 26130816

    During the last few decades, attention has increasingly focused on noninvasive ventilation (NIV) in the treatment of chronic respiratory failure. The University of Leuven and the University Hospitals Leuven therefore chose this topic for a 2-day working group session during their International S...
  4. Chronic hypoventilation syndromes and sleep-related hypoventilation.

    Journal of thoracic disease 7(8):1273 (2015) PMID 26380756 PMCID PMC4561264

    Chronic hypoventilation affects patients with disorders on any level of the respiratory system. The generation of respiratory impulses can be impaired in congenital disorders, such as central congenital alveolar hypoventilation, in alterations of the brain stem or complex diseases like obesity h...
  5. Mandibular Advancement Therapy for Obstructive Sleep Apnea: Answers and (More) Questions.

    JAMA Internal Medicine 175(8):1285 (2015) PMID 26030622

  6. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

    Cell 162(1):146 (2015) PMID 26140595

    KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively treat KRAS-mutant tumors. Here, we perform a cell-line-based screen and identify strong synergistic interactions between cell...
  7. Clinical applications of adaptive servoventilation devices: part 2.

    Chest 146(3):858 (2014) PMID 25180729

    Adaptive servoventilation (ASV) is an automated treatment modality used to treat many types of sleep-disordered breathing. Although default settings are available, clinician-specified settings determined in the sleep laboratory are preferred. Depending on the device, setting choices may include ...
  8. Anticyclic modulated ventilation versus continuous positive airway pressure in patients with coexisting obstructive sleep apnea and Cheyne-Stokes respiration: a randomized crossover trial.

    Sleep Medicine 15(8):874 (2014) PMID 24841107

    Although coexisting obstructive sleep apnea (OSA) and Cheyne-Stokes respiration (CSR) occur frequently in patients with heart diseases, optimal treatment remains unclear. Positive airway pressure (PAP) effectively treats OSA and adaptive servo-ventilation (ASV) has been shown to improve CSR. We ...
  9. Positive airway pressure therapy with adaptive servoventilation: part 1: operational algorithms.

    Chest 146(2):514 (2014) PMID 25091757

    The beginning of the 21st century witnessed the advent of new positive airway pressure (PAP) technologies for the treatment of central and complex (mixtures of obstructive and central) sleep apnea syndromes. Adaptive servoventilation (ASV) devices applied noninvasively via mask that act to maint...
  10. [Sleep disorders in asthma and chronic obstructive pulmonary disease (COPD)].

    Therapeutische Umschau 71(5):301 (2014) PMID 24794341

    Sleep disturbances (SD) are a frequent finding in patients with asthma and chronic obstructive pulmonary disease (COPD) and have a negative impact on quality of life and the clinical course of the disease. The causes of SD are multiple and include for example respiratory symptoms and comorbiditi...
  11. Response.

    Chest 143(6):1834 (2013) PMID 23732602

  12. A novel extracorporeal CO(2) removal system: results of a pilot study of hypercapnic respiratory failure in patients with COPD.

    Chest 143(3):678 (2013) PMID 23460154 PMCID PMC3590884

    Hypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated in these patients. This is a pilot study of a novel ECCO2R device that utilizes a single venous catheter...
  13. Evaluation of a noninvasive algorithm for differentiation of obstructive and central hypopneas.

    Sleep 36(3):363 (2013) PMID 23450252 PMCID PMC3571737

    The clear discrimination of central and obstructive hypopneas is highly relevant to avoid misinterpretation and inappropriate treatment of complicated breathing patterns. Esophageal manometry is the accepted standard for the differentiation of the phenotypes of sleep apnea. However, it is limite...
  14. Opioid-induced sleep apnea: is it a real problem?

    Journal of clinical sleep medicine : JCSM : off... 8(5):577 (2012) PMID 23066371 PMCID PMC3459205

  15. Long-term auto-servoventilation or constant positive pressure in heart failure and coexisting central with obstructive sleep apnea.

    Chest 142(2):440 (2012) PMID 22281801

    The coexistence of obstructive sleep apnea (OSA) and central sleep apnea (CSA) and Cheyne-Stokes respiration (CSR) is common in patients with heart failure (HF). While CPAP improves CSA/CSR by about 50%, maximal suppression is crucial in improving clinical outcomes. Auto-servoventilation (ASV) e...
  16. Every cloud has a silver lining--treatment of complicated breathing patterns during sleep.

    Sleep 34(12):1625 (2011) PMID 22131596 PMCID PMC3208836

  17. Inhibition of granulocyte migration by tiotropium bromide.

    Respiratory Research 12:24 (2011) PMID 21352583 PMCID PMC3051905

    Neutrophil influx into the airways is an important mechanism in the pathophysiology of the inflammatory process in the airways of patients with chronic obstructive pulmonary disease (COPD). Previously it was shown that anticholinergic drugs reduce the release of non-neuronal paracrine mediators,...
  18. Long-term therapy with continuous positive airway pressure in obstructive sleep apnea: adherence, side effects and predictors of withdrawal - a 'real-life' study.

    Respiration 82(2):155 (2011) PMID 21372549

    Long-term adherence to positive airway pressure (PAP) treatment is essential in patients with obstructive sleep apnea syndrome (OSAS). The aim of the present study was to analyze treatment adherence under real-life conditions and factors associated with discontinuation of PAP therapy. Patients n...
  19. Treatment options in Cheyne-Stokes respiration.

    Therapeutic Advances in Respiratory Disease 4(6):341 (2010) PMID 20713506

    About half of the patients suffering from heart failure present with sleep-disordered breathing. In most cases obstructive and central breathing disturbances (including Cheyne-Stokes respiration [CSR]) coexist. CSR is defined by a waxing and waning pattern of the tidal volume. While its pathophy...
  20. An invasive and a noninvasive approach for the automatic differentiation of obstructive and central hypopneas.

    Biomedical Engineering, IEEE Transactions on 57(8):1927 (2010) PMID 20403779

    The automatic differentiation of obstructive and central respiratory events is a major challenge in the diagnosis of sleep-disordered breathing. Esophageal pressure (Pes) measurement is the gold-standard method to identify these events. This study presents a new classifier that automatically dif...