Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence.
Aging Cell 15(3):542 (2016)
Eukaryotic genomes contain transposable elements (TE) that can move into new locations upon activation. Since uncontrolled transposition of TEs, including the retrotransposons and DNA transposons, can lead to DNA breaks and genomic instability, multiple mechanisms, including heterochromatin-medi...
Lamin in inflammation and aging.
Current Opinion in Cell Biology 40:124 (2016)
Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. Howev...
GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1.
Diabetologia 59(5):1059 (2016)
Accumulating evidence has revealed the significant role of glucagon-like peptide-1 (GLP-1) in weight loss. Sirtuin 1 (SIRT1) plays a vital role in the regulation of lipid metabolism. Here, we investigated the contribution of lipolytic and oxidative changes in white adipose tissue (WAT) to the we...
Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice.
Obesity 24(3):634 (2016)
Recent studies have revealed that SIRT1 gain-of-function could promote adipose tissue browning for the adaptive thermogenesis under normal diet. This study investigated the role of SIRT1 loss-of-function in diet-induced obesity and insulin resistance and the mechanism involved in adipose tissue ...
Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
Tumor Biology 37(3):3887 (2016)
It has been suggested that hexokinase 1 (HK1) is involved in tumorigenesis. However, the expression dynamics of HK1 and its prognostic significance in human colorectal cancer (CRC) still remain unclear. The aim of the present study was to investigate the expression of HK1 and its prognostic sign...
Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation.
Molecular and Cellular Endocrinology 422:31 (2016)
The onco-protein epidermal growth factor (EGF) initiates a cascade that includes activation of the ERK and AKT signaling pathways and alters gene expression. We describe a new action of EGF-EGF receptor (EGFR), rapid anticipatory activation of the endoplasmic reticulum stress sensor, the unfolde...
Relationship of Oct-4 to malignant stage: a meta-analysis based on 502 positive/high Oct-4 cases and 522 negative/low case-free controls.
Oncotarget 7(2):2143 (2016)
Octamer 4 (Oct-4), an important member of the POU domain transcription factor family, has been suggested to function as a master switch during differentiation of human somatic cells and more recently has come to be linked with neoplastic properties. The aim of this study was to evaluate the rela...
Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis.
Cell Reports 13(7):1505 (2015)
Understanding how chromatin modification regulates development and disease can be limited by available material. Despite recent progress, balancing high-quality and reliable mapping using chromatin-immunoprecipitation-based deep sequencing (ChIP-seq) remains a challenge. We report two techniques...
Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia
Cell 163(1):256 (2015)
Association of the intermediate filament nestin with cancer stage: a meta-analysis based on 223 positive/high nestin cases and 460 negative/low case-free controls.
Oncotarget 6(26):22970 (2015)
Nestin, a member of the intermediate filament protein family, has been reported to be associated with several types of neoplastic transformation. However, questions remain, with studies reporting sometimes inconclusive or conflicting data. Thus, the aim of this study was to evaluate literature r...
[Expression and clinical significance of G protein-coupled receptor 31 in colorectal cancer tissue].
Zhonghua wei chang wai ke za zhi = Chinese jour... 18(9):935 (2015)
To investigate the expression and clinical significance of G protein-coupled receptor 31 (GPR31) in colorectal cancer tissue.
Cancer tissues and adjacent normal tissues of 321 cases with colorectal cancer confirmed by pathology and undergoing resection in the First Affiliated Hospital of Sun Yat...
Identification of lamin B-regulated chromatin regions based on chromatin landscapes.
Molecular Biology of the Cell 26(14):2685 (2015)
Lamins, the major structural components of the nuclear lamina (NL) found beneath the nuclear envelope, are known to interact with most of the nuclear peripheral chromatin in metazoan cells. Although NL-chromatin associations correlate with a repressive chromatin state, the role of lamins in teth...
Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing.
Journal of Cell Biology 209(2):235 (2015)
Although studies suggest that perturbing mitotic progression leads to DNA damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. We show that BuGZ and Bub3, which are two mitotic regulators localized in...
Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression.
PNAS 112(15):4737 (2015)
Recurrent estrogen receptor α (ERα)-positive breast and ovarian cancers are often therapy resistant. Using screening and functional validation, we identified BHPI, a potent noncompetitive small molecule ERα biomodulator that selectively blocks proliferation of drug-resistant ERα-positive breast ...
Gas1 is a receptor for sonic hedgehog to repel enteric axons.
PNAS 112(1):E73 (2015)
The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
Lamin-B in systemic inflammation, tissue homeostasis, and aging.
Nucleus (Austin, Tex. : Print) 6(3):183 (2015)
Gradual loss of tissue function (or homeostasis) is a natural process of aging and is believed to cause many age-associated diseases. In human epidemiology studies, the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies. A...
miR-106a Is Downregulated in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B and Associated with Enhanced Levels of Interleukin-8.
Mediators of Inflammation 2015:629862 (2015)
This study aimed to investigate miR-106a expression in peripheral blood mononuclear cells (PBMCs) of chronic hepatitis B (CHB) patients and to analyze the function of miR-106a.
miR-106a expression levels in PBMCs from 40 healthy controls and 56 CHB patients were analyzed by quantitative real-tim...
Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia.
Cell 159(4):829 (2014)
Aging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unclear. We report that the Drosophila fat body, a major immune organ, undergoes immunose...
SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis.
Diabetes 63(11):3637 (2014)
GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by acc...
A movable microelectrode array for chronic basal ganglia single-unit electrocorticogram co-recording in freely behaving rats.
Neurological Sciences 35(9):1429 (2014)
The basal ganglia-cortical circuits are important for information process to brain function. However, chronic recording of single-unit activities in the basal ganglia nucleus has not yet been well established. We present a movable bundled microwire array for chronic subthalamic nucleus (STN) sin...