Lithium-free processing of silk fibroin.
Journal of Biomaterials Applications 31(3):450 (2016)
Silk fibroin protein was purified from Bombyx mori silkworm cocoons using a novel dialysis strategy to avoid fibroin aggregation and pre-mature formation of β-sheets. The degummed silk fibers were dissolved in Ajisawa's reagent, a mixture of CaCl2-EtOH-H2O, that is less expensive than lithium br...
Distinct Subthreshold Mechanisms Underlying Rate-Coding Principles in Primate Auditory Cortex.
Neuron 91(4):905 (2016)
A key computational principle for encoding time-varying signals in auditory and somatosensory cortices of monkeys is the opponent model of rate coding by two distinct populations of neurons. However, the subthreshold mechanisms that give rise to this computation have not been revealed. Because t...
Control of silk microsphere formation using polyethylene glycol (PEG).
Acta Biomaterialia 39:156 (2016)
A one step, rapid method to prepare silk microspheres was developed, with particle size controlled by the addition of polyethylene glycol (PEG). PEG molecular weight (4.0K-20.0KDa) and concentration (20-50wt%), as well as silk concentration (5-20wt%), were key factors that determined particle si...
(99) Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral γδ T cells and CD4(+) CD25(+) Foxp3(+) Tregs.
International Journal of Rheumatic Diseases 19(6):586 (2016)
γδ T cells exhibit important functions in the pathogenesis of rheumatoid arthritis (RA). In recent years, numerous studies harnessed the γδ T cell-activating capacity of aminobiphosphonates for the treatment of malignant tumors. As (99) Tc-methylene diphosphonate ((99) Tc-MDP) has long been wide...
Stabilization of Natural Antioxidants by Silk Biomaterials.
ACS Applied Materials & Interfaces 8(21):13573 (2016)
The stabilities of three natural antioxidants, vitamin C (VC), (-)-epigallocatechin gallate (EGCG), and curcumin, in silk films were examined and mechanisms of stabilization were elucidated. The antioxidants were physically incorporated into three types of silk films: as-cast, dried from hydroge...
The quality of evidence in Chinese meta-analyses needs to be improved.
Journal of Clinical Epidemiology 74:73 (2016)
We conducted a systematic review using GRADE (Grading of Recommendations Assessment, Development and Evaluation) system to assess the quality of evidence of Chinese meta-analyses (MAs).
A systematic review of MAs listed in Chinese Biomedicine Literature Database from January 2010 to December 201...
A Rare Case of Pulmonary Artery Dissection Associated With Infective Endocarditis.
Medicine (Baltimore) 95(19):e3358 (2016)
Pulmonary artery dissection (PAD) is a rare condition with high mortality and has not been reported in patient with infective endocarditis (IE). Here, we report the first case of such patient who experienced PDA and survived after surgical intervention.A 10-year-old female child was diagnosed as...
Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel.
International Journal of Pharmaceutics 503(1-2):229 (2016)
Minimally invasive delivery and sustained release of therapeutics to the inner ear are of importance to the medical treatment of inner ear disease. In this study, the injectable silk fibroin-polyethylene glycol (Silk-PEG) hydrogel was investigated as a drug delivery carrier to deliver poorly sol...
Marmosets: A Neuroscientific Model of Human Social Behavior.
Neuron 90(2):219 (2016)
The common marmoset (Callithrix jacchus) has garnered interest recently as a powerful model for the future of neuroscience research. Much of this excitement has centered on the species' reproductive biology and compatibility with gene editing techniques, which together have provided a path for t...
Relationship between structure and immunological activity of an arabinogalactan from Lycium ruthenicum.
Food Chemistry 194:595 (2016)
An immunologically active arabinogalactan (LRGP3) was selectively degraded by acetolysis, mild acid hydrolysis and enzymatic digestion. After exo-α-l-arabinofuranosidase digestion, 56% of the arabinosyl chains were released. The resistant product (LRGP3-AF) had markedly increased complement fixa...
The Ying and Yang of Auditory Nerve Damage.
Neuron 89(4):680 (2016)
Chambers et al. investigate consequences in the central auditory system after profound cochlear denervation. They observed gains in firing rate in auditory cortex despite nearly absent auditory nerve and brainstem responses, suggesting an important role of central plasticity and its clinical imp...
Complex pitch perception mechanisms are shared by humans and a New World monkey.
PNAS 113(3):781 (2016)
The perception of the pitch of harmonic complex sounds is a crucial function of human audition, especially in music and speech processing. Whether the underlying mechanisms of pitch perception are unique to humans, however, is unknown. Based on estimates of frequency resolution at the level of t...
Rice cropping density and intensity lessened in southeast China during the twenty-first century.
Environmental Monitoring and Assessment 188(1):5 (2016)
Accurate and updated time series maps of paddy rice distribution and planting intensity will greatly improve our knowledge. Unfortunately, spatiotemporal explicit information on rice fields is relatively limited, and considerable uncertainties still exist as regards to its inter-annual variation...
Research gap of guidelines might be an important approach to prioritization (Letter commenting on: J Clin Epidemiol. 2015;68:341-6).
Journal of Clinical Epidemiology 69:251 (2016)
Plasmid-Based Stat3 siRNA Delivered by Functional Graphene Oxide Suppresses Mouse Malignant Melanoma Cell Growth.
Oncology Research 23(5):229 (2016)
RNA interference (RNAi) has been used for cancer gene therapy in recent years. However, the application of RNAi is hindered in the absence of safe and efficient gene delivery. In this article, a novel vehicle of graphene oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-...
Endogenous Small-Noncoding RNAs and Potential Functions in Desiccation Tolerance in Physcomitrella Patens.
Scientific reports 6:30118 (2016)
Early land plants like moss Physcomitrella patens have developed remarkable drought tolerance. Phytohormone abscisic acid (ABA) protects seeds during water stress by activating genes through transcription factors such as ABSCISIC ACID INSENSITIVE (ABI3). Small noncoding RNA (sncRNA), including m...
Green tea extract catechin improves internal cardiac muscle relaxation in RCM mice.
Journal of Biomedical Science 23(1):51 (2016)
Diastolic dysfunction refers to an impaired relaxation and an abnormality in a heart's filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed in patients with primary hypertension, diabetes and cardiomyopathies such as hypertroph...
[Transcatheter occlusion of patent ductus arteriosus in a preterm infant and review of literatures].
Zhonghua er ke za zhi. Chinese journal of pedia... 54(1):43 (2016)
To investigate the characteristics of haemodynamically significant patent ductus arteriosus (hsPDA), and the indications of percutaneous transcatheter PDA occlusion.
The data of a preterm infant admitted to West China Second Hospital in December. 2013, who finally underwent percutaneous transcat...
A high density genetic map and QTL for agronomic and yield traits in Foxtail millet [Setaria italica (L.) P. Beauv].
BMC Genomics 17(1):336 (2016)
Foxtail millet [Setaria italica (L.) P. Beauv.], a crop of historical importance in China, has been adopted as a model crop for studying C-4 photosynthesis, stress biology and biofuel traits. Construction of a high density genetic map and identification of stable quantitative trait loci (QTL) la...
Optimization and in vitro antiproliferation of Curcuma wenyujin's active extracts by ultrasonication and response surface methodology.
Chemistry Central Journal 10:32 (2016)
Curcuma wenyujin, a member of the genus Curcuma, has been widely prescribed for anti-cancer therapy. Multiple response surface optimization has attracted a great attention, while, the research about optimizing three or more responses employing response surface methodology (RSM) was very few.