1. Sensitive characterization of polyphenolic antioxidants in Polygonatum odoratum by selective solid phase extraction and high performance liquid chromatography-diode array detector-quadrupole time-of-flight tandem mass spectrometry.

    Journal of Pharmaceutical and Biomedical Analysis 112:15 (2015) PMID 25942343

    The complexity of natural products always leads to the co-elution of interfering compounds with bioactive compounds, which then has a detrimental effect on structural elucidation. Here, a new method, based on selective solid phase extraction combined with 1,1-diphenyl-2-picrylhydrazyl radical (D...
  2. Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation.

    Brain, Behavior, and Immunity 48:287 (2015) PMID 25900440

    Glial cell response to injury has been well documented in the pathogenesis after traumatic brain injury (TBI) and spinal cord injury (SCI). Although microglia, the resident macrophages in the central nervous system (CNS), are responsible for clearing debris and toxic substances, excessive activa...
  3. Accurate Vessel Segmentation With Constrained B-Snake.

    Image Processing, IEEE Transactions on 24(8):2440 (2015) PMID 25861085

    We describe an active contour framework with accurate shape and size constraints on the vessel cross-sectional planes to produce the vessel segmentation. It starts with a multiscale vessel axis tracing in a 3D computed tomography (CT) data, followed by vessel boundary delineation on the cross-se...
  4. High-capacity magnetic hollow porous molecularly imprinted polymers for specific extraction of protocatechuic acid.

    Journal of chromatography. A 1404:21 (2015) PMID 26044378

    Magnetic hollow porous molecularly imprinted polymers (HPMIPs) with high binding capacity, fast mass transfer, and easy magnetic separation have been fabricated for the first time. In this method, HPMIPs was firstly synthesized using protocatechuic acid (PCA) as template, 4-vinylpyridine (4-VP) ...
  5. Hydrophilic gallic acid–imprinted polymers over magnetic mesoporous silica microspheres with excellent molecular recognition ability in aqueous fruit juices

    Food Chemistry 179:206 (2015)

    • Hydrophilic Fe3O4@SiO2@mSiO2@MIPs with excellent recognition ability. • The composites combined the advantages of Fe3O4, mSiO2, PDA and MIPs. ...
  6. Hydrophilic gallic acid-imprinted polymers over magnetic mesoporous silica microspheres with excellent molecular recognition ability in aqueous fruit juices.

    Food Chemistry 179:206 (2015) PMID 25722156

    Hydrophilic molecularly imprinted polymers (MIPs) for gallic acid (GA) were prepared with excellent recognition ability in an aqueous solution. The proposed MIPs were designed by self-polymerization of dopamine (DA) on magnetic mesoporous silica (Fe3O4@SiO2@mSiO2, MMS) using GA as template. Resu...
  7. Hydrophilic gallic acid–imprinted polymers over magnetic mesoporous silica microspheres with excellent molecular recognition ability in aqueous fruit juices

    Food Chemistry 179:206 (2015)

    • Hydrophilic Fe3O4@SiO2@mSiO2@MIPs with excellent recognition ability. • The composites combined the advantages of Fe3O4, mSiO2, PDA and MIPs. ...
  8. Hydrophilic gallic acid–imprinted polymers over magnetic mesoporous silica microspheres with excellent molecular recognition ability in aqueous fruit juices

    Food Chemistry 179:206 (2015)

    • Hydrophilic Fe3O4@SiO2@mSiO2@MIPs with excellent recognition ability. • The composites combined the advantages of Fe3O4, mSiO2, PDA and MIPs. ...
  9. Hydrophilic gallic acid-imprinted polymers over magnetic mesoporous silica microspheres with excellent molecular recognition ability in aqueous fruit juices.

    Food Chemistry 179:206 (2015) PMID 25722156

    Hydrophilic molecularly imprinted polymers (MIPs) for gallic acid (GA) were prepared with excellent recognition ability in an aqueous solution. The proposed MIPs were designed by self-polymerization of dopamine (DA) on magnetic mesoporous silica (Fe3O4@SiO2@mSiO2, MMS) using GA as template. Resu...
  10. Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

    Cell Reports 12(2):258 (2015) PMID 26146073

    As the list of putative driver mutations in glioma grows, we are just beginning to elucidate the effects of dysregulated developmental signaling pathways on the transformation of neural cells. We have employed a postnatal, mosaic, autochthonous glioma model that captures the first hours and days...
  11. Photon harvesting, coloring and polarizing in photovoltaic cell integrated color filters: efficient energy routing strategies for power-saving displays.

    Nanotechnology 26(26):265203 (2015) PMID 26062682

    We describe the integral electro-optical strategies that combine the functionalities of photovoltaic (PV) electricity generation and color filtering as well as polarizing to realize more efficient energy routing in display technology. Unlike the conventional pigment-based filters and polarizers,...
  12. Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling.

    Oncotarget 6(18):16352 (2015) PMID 25970785

    Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype associated with a poor prognosis. The mechanism involved in TNBC progression remains largely unknown. To date, there are no effective therapeutic targets for this tumor subtype. In this study, by performing quantitative pr...
  13. FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.

    Cancer Letters 362(1):70 (2015) PMID 25827072 PMCID PMC4406488

    The Snail family of transcription factors are core inducers of epithelial-to-mesenchymal transition (EMT). Here we show that the F-box protein FBXO11 recognizes and promotes ubiquitin-mediated degradation of multiple Snail family members including Scratch. The association between FBXO11 and Snai...
  14. Pharmacokinetics, safety, and tolerability of single and multiple-doses of pinocembrin injection administered intravenously in healthy subjects.

    Journal of Ethnopharmacology 168:31 (2015) PMID 25814318

    Pinocembrin is the most abundant flavonoid in propolis. Preclinical studies have suggested that pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. To investigate the safety, tolerability and pharmacokinetics of a new neuropro...
  15. Ultrathin Spinel-Structured Nanosheets Rich in Oxygen Deficiencies for Enhanced Electrocatalytic Water Oxidation.

    Angewandte Chemie. International edition in Eng... 54(25):7399 (2015) PMID 25951435

    Electrochemical water splitting is a clean technology for H2 fuels, but greatly hindered by the slow kinetics of the oxygen evolution reaction (OER). Herein, a series of spinel-structured nanosheets with oxygen deficiencies and ultrathin thicknesses were designed to increase the reactivity and t...
  16. Analysis and improved characterization of minor antioxidants from leaves of Malus doumeri using a combination of major constituents' knockout with high-performance liquid chromatography-diode array detector-quadrupole time-of-flight tandem mass spectrometry.

    Journal of chromatography. A 1398:57 (2015) PMID 25912788

    Due to the complexity of natural products, efficient identification of bioactive compounds, especially for minor compounds, would require a huge effort. Here, we developed an effective strategy based on combining major constituents' knockout with high-performance liquid chromatography-diode arra...
  17. Highly Cost-Effective Nitrogen-Doped Porous Coconut Shell-Based CO2 Sorbent Synthesized by Combining Ammoxidation with KOH Activation.

    Environmental Science & Technology 49(11):7063 (2015) PMID 25961379

    The objective of this research is to develop a cost-effective carbonaceous CO2 sorbent. Highly nanoporous N-doped carbons were synthesized with coconut shell by combining ammoxidation with KOH activation. The resultant carbons have characteristics of highly developed porosities and large nitroge...
  18. Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression.

    Journal of Biomolecular Screening 20(5):663 (2015) PMID 25477201 PMCID PMC4486263

    Carboxyl-terminal binding protein (CtBP) is a transcriptional corepressor that suppresses multiple proapoptotic and epithelial genes. CtBP is overexpressed in many human cancers, and its overexpression increases stem cell-like features, epithelial-mesenchymal transition, and cancer cell survival...
  19. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

    Science Translational Medicine 7(282):282ra49 (2015) PMID 25855495

    Hepatitis C virus (HCV) infection affects an estimated 185 million people worldwide, with chronic infection often leading to liver cirrhosis and hepatocellular carcinoma. Although HCV is curable, there is an unmet need for the development of effective and affordable treatment options. Through a ...
  20. In Vitro and In Vivo Characterization of 13 CYP2C9 Allelic Variants Found in Chinese Han Population.

    Drug Metabolism and Disposition 43(4):561 (2015) PMID 25614704

    Our previous study detected totally 35 CYP2C9 allelic variants in 2127 Chinese subjects, of whom 21 novel alleles were reported for the first time in Chinese populations. The aim of the present study was to characterize the 13 CYP2C9 allelic variants both in vitro and in vivo. Different types of...