1. Effects of biological age on the associations of blood pressure with cardiovascular and non-cardiovascular mortality in old age: A population-based study.

    International Journal of Cardiology 220:508 (2016) PMID 27390978

    Whether chronological or biological age may play a role in the association between blood pressure and cause-specific mortality in old age is unclear. We seek to investigate the associations of blood pressure with all-cause, cardiovascular, and non-cardiovascular mortality among older people and ...
  2. Tracking Body Mass Index From Childhood to Adulthood for Subclinical Cardiovascular Diseases at Adulthood.

    Journal of the American College of Cardiology 67(8):1006 (2016) PMID 26916492

  3. Interactive effects of diabetes and impaired kidney function on cognitive performance in old age: a population-based study.

    BMC Geriatrics 16(1):7 (2016) PMID 26753625 PMCID PMC4710025

    The interactive effect between diabetes and impaired kidney function on cognitive impairment in older adults has not yet been reported. The aim of this study was to investigate the association of diabetes and impaired kidney function with cognitive impairment among Chinese older people living in...
  4. Use of medications and functional dependence among Chinese older adults in a rural community: A population-based study.

    Geriatrics and Gerontology International 15(12):1242 (2015) PMID 25598446

    To investigate the associations between medication use and functional dependence in Chinese older people living in a rural community. The cross-sectional study included 1538 participants (age ≥60 years, 59.1% women) in the Confucius Hometown Aging Project in Shandong, China. In June 2010 to July...
  5. GW26-e4593 Childhood adiposity is associated with carotid atherosclerosis and left ventricular hypertrophy but not with arterial stiffness at adulthood: Beijing Blood Pressure Cohort Study

    Journal of the American College of Cardiology 66(16):C107 (2015)

  6. The Confucius Hometown Aging Project: a community-based study of ageing and health in a rural area

    The Lancet 386:S57 (2015)

    Background Vascular risk factors (eg, smoking, hypertension, and diabetes) are associated with cognitive and physical dysfunction in old age. We hypothesised that atherosclerotic process plays a central part in linking vascular risk factors and disorders to cognitive and phys...
  7. Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.

    Cancer Research 75(17):3672 (2015) PMID 26141861

    Cancer stem-like cells (CSC) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, and give rise to metastases. Metadherin (MTDH) contributes widely to tumor growth, drug resistance, relapse, and metastasis, but its molecular mechanisms of action are not well understood. Here...
  8. Childhood obesity affects adult metabolic syndrome and diabetes.

    Endocrine 50(1):87 (2015) PMID 25754912

    We seek to observe the association between childhood obesity by different measures and adult obesity, metabolic syndrome (MetS), and diabetes. Thousand two hundred and nine subjects from "Beijing Blood Pressure Cohort Study" were followed 22.9 ± 0.5 years in average from childhood to adulthood. ...
  9. Trends in disability in activities of daily living among Chinese older adults, 1997-2006: the China Health and Nutrition Survey.

    Journals of Gerontology Series A: Biological Sc... 70(6):739 (2015) PMID 25414515 PMCID PMC4506321

    A decline in prevalence of late-life disability in activities of daily living (ADLs) has been reported in Western countries. We investigate the time trend of disability in basic ADLs among Chinese older people in 1997-2006, and explore the potential contribution of cardiometabolic diseases to th...
  10. Prevalence and Patterns of Chronic Disease Pairs and Multimorbidity among Older Chinese Adults Living in a Rural Area.

    PLoS ONE 10(9):e0138521 (2015) PMID 26394368 PMCID PMC4578976

    The burden of chronic diseases in China is substantial now. Data on patterns of chronic diseases and multimorbidity among older adults, especially among those living in rural areas, are sparse. We aim to investigate the prevalence and patterns of chronic disease pairs and multimorbidity in elder...
  11. Prevalence, pharmacological treatment, and control of cardiometabolic risk factors among older people in central Stockholm: a population-based study.

    PLoS ONE 10(3):e0119582 (2015) PMID 25799502 PMCID PMC4370718

    Cardiometabolic risk factors and related cardiovascular diseases represent major threats to healthy aging. We aimed to estimate distribution, pharmacological treatment, and control of main cardiometabolic risk factors among older people. This population-based study included 3363 participants (ag...
  12. Cardiovascular target organ damage could have been detected in sustained pediatric hypertension.

    Blood Pressure 24(5):284 (2015) PMID 26024395

    The aim of this study was to assess sustained hypertension in children and its impact on cardiovascular target organ damage (TOD). Blood pressure (BP) was measured in children in Beijing in 2009. Primary hypertension was diagnosed based on three separate visits. Hypertensive children and normote...
  13. Cardiovascular remodeling relates to elevated childhood blood pressure: Beijing Blood Pressure Cohort Study.

    International Journal of Cardiology 177(3):836 (2014) PMID 25465829

    There are few studies investigating the long-term association between childhood blood pressure (BP) and adult cardiovascular remodeling. We seek to examine the effect of elevated childhood BP on cardiovascular remodeling in early or middle adulthood. We used the "Beijing BP Cohort Study", where ...
  14. Highly prevalent and poorly controlled cardiovascular risk factors among Chinese elderly people living in the rural community.

    European Journal of Preventive Cardiology 21(10):1267 (2014) PMID 23598595

    The epidemiological scenario of cardiovascular risk factors (CRFs) among elderly people in rural China is unclear. We seek to describe the distribution, burden and management of major CRFs among older Chinese people living in the rural community. This cross-sectional study included 1538 particip...
  15. Expression and localization of Smad2 and Smad4 proteins in the porcine ovary.

    Acta Histochemica 116(8):1301 (2014) PMID 25190106

    The objective of the present study was to investigate the temporal and spatial expression of Smad2 and Smad4 proteins, the downstream signaling molecules of the transforming growth factor beta (TGF-β) superfamily, in the porcine ovary. Cellular localization of Smad2 and Smad4 proteins was examin...
  16. Vascular risk factor burden, atherosclerosis, and functional dependence in old age: a population-based study.

    International Journal of Behavioral Medicine 21(4):597 (2014) PMID 24057410

    Vascular risk factors such as hypertension and obesity have been associated with physical limitations among older adults. The purpose of this study is to examine whether individual and aggregated vascular risk factors (VRFs) are associated with functional dependence and to what extent carotid at...
  17. Association between lipid profile and depressive symptoms among Chinese older people: mediation by cardiovascular diseases?

    International Journal of Behavioral Medicine 21(4):590 (2014) PMID 24136399

    The potential mediating effect of cardiovascular diseases (CVDs) (e.g., ischemic heart disease and stroke) on the association between abnormal serum lipids and late-life depressive symptoms has not been investigated. We aimed to examine the associations between serum lipids and elevated depressi...
  18. Trends in incidence of hypertension in Chinese adults, 1991-2009: the China Health and Nutrition Survey.

    International Journal of Cardiology 175(1):96 (2014) PMID 24833472 PMCID PMC4105139

    Previous studies have shown an upward trend in the prevalence of hypertension, but data on trend of incidence of hypertension are lacking. We seek to investigate the trends in incidence of hypertension and control of incident hypertension among Chinese adults during 1991-1997 and 2004-2009. With...
  19. Hypertension screening using blood pressure to height ratio.

    Pediatrics 134(1):e106 (2014) PMID 24913794 PMCID PMC4067644

    The definition of hypertension in children is too complex to be used by medical professionals and children and their parents because of the age-, gender-, and height-specific blood pressure (BP) algorithm. The aim of this study was to simplify the pediatric BP percentile references using BP to h...
  20. Metabolic syndrome and subclinical carotid atherosclerosis among Chinese elderly people living in a rural community.

    Metabolic Syndrome and Related Disorders 12(5):269 (2014) PMID 24588080

    The relationship between the metabolic syndrome and subclinical atherosclerosis among elderly people remains controversial. We seek to investigate the associations of metabolic syndrome and its components with subclinical carotid atherosclerosis in older people living in rural China. This cross-...