1. Peroxygenase-Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol.

    Angewandte Chemie. International edition in Eng... 55(2):798 (2016) PMID 26607550

    Peroxygenases catalyze a broad range of (stereo)selective oxyfunctionalization reactions. However, to access their full catalytic potential, peroxygenases need a balanced provision of hydrogen peroxide to achieve high catalytic activity while minimizing oxidative inactivation. Herein, we report ...
  2. Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations.

    Scientific reports 6:20594 (2016) PMID 26846565 PMCID PMC4742847

    Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs and AAAs) are closely associated with the risk of developing type 2 diabetes in several Western countries. The aim of this study was to evaluate the potential role of BCAAs and AAAs in predicting the diab...
  3. A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.

    Scientific reports 6:28418 (2016) PMID 27344992 PMCID PMC4921829

    Increasing evidences support that metabolically healthy obese (MHO) is a transient state. However, little is known about the early markers associated with the development of metabolic abnormalities in MHO individuals. Serum free fatty acids (FFAs) profile is highlighted in its association with o...
  4. LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer.

    Breast Cancer Research and Treatment 154(3):473 (2015) PMID 26564482 PMCID PMC4854534

    Long non-coding RNAs (lncRNAs) are a class of newly recognized DNA transcripts that have diverse biological activities. Dysregulation of lncRNAs may be involved in many pathogenic processes including cancer. Recently, we found an intergenic lncRNA, LINC00472, whose expression was correlated with...
  5. Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients.

    Journal of Clinical Endocrinology & Metabolism 100(11):4222 (2015) PMID 26425885

    Bile acids (BAs) have been suggested as key mediators of the improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB). The objective of the study was to test whether the individual or a group of BAs have potential value to predict diabetes remission after RYGB. A retrospective co...
  6. Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals.

    EBioMedicine 2(10):1513 (2015) PMID 26629547 PMCID PMC4634820

    Obesity is not a homogeneous condition across individuals since about 25-40% of obese individuals can maintain healthy status with no apparent signs of metabolic complications. The simple anthropometric measure of body mass index does not always reflect the biological effects of excessive body f...
  7. [Chemical constituents from Crepis crocea].

    China Journal of Chinese Materia Medica 40(19):3800 (2015) PMID 26975105

    Thirteen compounds were isolated from the ethyl acetate fraction of Crepis crocea by column chromatographies on silica gel, Sephadex LH-20 and semi-preparative HPLC. The structures were elucidated on the basis of spectral analysis as tectorone I (1), 8β- (2-methyl- 2-hydroxy-3-oxobutanoyloxy) -g...
  8. Metabonomics reveals metabolite changes in biliary atresia infants.

    Journal of Proteome Research 14(6):2569 (2015) PMID 25899098

    Biliary atresia (BA) is a rare neonatal cholestatic disorder caused by obstruction of extra- and intra-hepatic bile ducts. If untreated, progressive liver cirrhosis will lead to death within 2 years. Early diagnosis and operation improve the outcome significantly. Infants with neonatal hepatitis...
  9. Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MS.

    Journal of Proteome Research 14(2):850 (2015) PMID 25581415

    Bile acids (BAs) are a group of important physiological agents for cholesterol metabolism, intestinal nutrient absorption, and biliary secretion of lipids, toxic metabolites, and xenobiotics. Extensive research in the last two decades has unveiled new functions of BAs as signaling molecules and ...
  10. Serum metabolite signatures of type 2 diabetes mellitus complications.

    Journal of Proteome Research 14(1):447 (2015) PMID 25245142

    A number of metabolic conditions, including hypoglycemia, high blood pressure (HBP), dyslipidemia, nerve damage and amputation, and vision problems, occur as a result of uncontrolled blood glucose levels over a prolonged period of time. The different components of diabetic complications are not ...
  11. Efficient synthesis of an ε-hydroxy ester in a space–time yield of 1580 g L−1 d−1 by a newly identified reductase RhCR

    Tetrahedron: Asymmetry 25(23):1501 (2014)

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  12. Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery.

    Journal of Proteome Research 13(9):3857 (2014) PMID 25105552

    Colorectal cancer (CRC) is one of the most common cancers in the world, having both high prevalence and mortality. It is usually diagnosed at advanced stages due to the limitations of current screening methods used in the clinic. There is an urgent need to develop new biomarkers and modalities t...
  13. Improvedo-chlorobenzoylformate bioreduction by stabilizing aldo-keto reductase YtbE with additives

    Journal of Molecular Catalysis B: Enzymatic 104:108 (2014)

  14. Pyrococcus furiosus-mediated reduction of conjugated carboxylic acids: Towards using syngas as reductant

    Journal of Molecular Catalysis B: Enzymatic 103:52 (2014)

  15. An ene reductase from Clavispora lusitaniae for asymmetric reduction of activated alkenes.

    Enzyme and Microbial Technology 56:40 (2014) PMID 24564901

    A putative ene reductase gene from Clavispora lusitaniae was heterologously overexpressed in Escherichia coli, and the encoded protein (ClER) was purified and characterized for its biocatalytic properties. This NADPH-dependent flavoprotein was identified with reduction activities toward a divers...
  16. Performance of a new thermostable mannanase in breaking guar-based fracturing fluids at high temperatures with little premature degradation.

    Applied Biochemistry and Biotechnology 172(3):1215 (2014) PMID 24150905

    A new thermostable β-1,4-mannanase (DtManB) cloned from Dictyoglomus thermophilum CGMCC 7283 showed the maximum activity towards hydroxypropyl guar gum at 80 °C, with a half-life of 46 h. DtManB exhibited good compatibility with various additives of fracturing fluid, retaining more than 50 % act...
  17. Analysis of epileptic seizures with complex network.

    Computational and Mathematical Methods in Medicine 2014:283146 (2014) PMID 25147576 PMCID PMC4134795

    Epilepsy is a disease of abnormal neural activities involving large area of brain networks. Until now the nature of functional brain network associated with epilepsy is still unclear. Recent researches indicate that the small world or scale-free attributes and the occurrence of highly clustered ...
  18. Photosynthetic responses and accumulation of mesotrione in two freshwater algae.

    Environmental Science Processes and Impacts 16(10):2288 (2014) PMID 25059419

    Mesotrione is a herbicide used for killing annual grasses and broad-leaved weeds in maize. A recent investigation has shown that mesotrione has been detected as an organic contaminant in aquatic environments and may have a negative impact on aquatic organisms. To evaluate the eco-toxicity of mes...
  19. Unique properties associated with normal martensitic transition and strain glass transition – A simulation study

    Journal of Alloys and Compounds 577:S102 (2013)

    Highlights ► We model the unique properties of strain glass which is different from that of normal martensite. ► We describe the importance of point defects in the formation of strain glass and related properties. ► The role of point defect can be attributed to global transit...
  20. The effect of point defects on ferroelastic phase transition of lanthanum-doped calcium titanate ceramics

    Journal of Alloys and Compounds 577:S468 (2013)

    Highlights ► The effect of point defects on phase transitions in Ca(1−x)La2x/3TiO3 was studied. ► When x=0.45, normal ferroelastic phase transition happens. ► When x=0.7, a “glassy-like” frozen process appears. ► Point defects weaken the thermodynamic stability of ferroelasti...