Substrate stiffness orchestrates epithelial cellular heterogeneity with controlled proliferative pattern via E-cadherin/β-catenin mechanotransduction.
Acta Biomaterialia 41:169 (2016)
Epithelial cellular heterogeneity has been observed in pathological tissues with abnormal matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how matrix stiffness influences cellular heterogeneity formation in multi-cellular population. Here, we demonstrated that...
Microcatheter-assisted trabeculotomy versus rigid probe trabeculotomy in childhood glaucoma.
British Journal of Ophthalmology 100(9):1257 (2016)
To compare microcatheter-assisted trabeculotomy with standard rigid probe trabeculotomy for the treatment of childhood glaucoma.
The early postoperative (12 months) results of microcatheter-assisted trabeculotomy (group 1) performed by single surgeon were retrospectively compared with those of r...
Thiazole orange as a fluorescent probe: Label-free and selective detection of silver ions based on the structural change of i-motif DNA at neutral pH.
Talanta 156-157:141 (2016)
Silver ions have been widely applied to many fields and have harmful effects on environments and human health. Herein, a label-free optical sensor for Ag(+) detection is constructed based on thiazole orange (TO) as a fluorescent probe for the recognition of i-motif DNA structure change at neutra...
Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Journal of Hepatology 65(2):325 (2016)
Pediatric liver cancer is a rare but serious disease whose incidence is rising, and for which the therapeutic options are limited. Development of more targeted, less toxic therapies is hindered by the lack of an experimental animal model that captures the heterogeneity and metastatic capability ...
Swelling, mechanical and friction properties of PVA/PVP hydrogels after swelling in osmotic pressure solution.
Materials Science and Engineering: C 65:172 (2016)
The potential of polyvinyl alcohol/polyvinylpyrrolidone (PVA/PVP) hydrogels as articular cartilage replacements was in vitro evaluated by using a macromolecule-based solution to mimic the osmotic environment of cartilage tissue. The effects of osmotic pressure solution on the morphology, crystal...
Kinetic and product composition study on the cellulose liquefaction in polyhydric alcohols.
Bioresource Technology 214:419 (2016)
The liquefaction process of cellulose in polyhydric alcohols (PEG 400 and glycerol) was studied by TG-FTIR. Three stages were observed during the solvolysis process and the main liquefaction stage could be further divided into two zones. The differences of liquefaction behavior of cellulose in t...
MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival.
Clinical Cancer Research 22(15):3841 (2016)
Prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase-2; a target of aspirin) produces inflammatory mediator prostaglandin E2 (PGE2), and contributes to colorectal neoplasia development. PTGS2-driven inflammatory responses can induce tumor expression of microRNA MIR21 (miR-21) that can in...
A potential fluorescent probe: Maillard reaction product from glutathione and ascorbic acid for rapid and label-free dual detection of Hg(2+) and biothiols.
Biosensors and Bioelectronics 81:473 (2016)
Maillard reactions and their fluorescent products have drawn much attention in the fields of food and life science, however, the application of fluorescent products separated from the reaction as an indicator for detection of certain substances in sensor field has not been mentioned. In this art...
Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway.
Cell Stress & Chaperones 21(4):697 (2016)
Neuroinflammation is closely associated with the pathophysiology of neurodegenerative diseases including Parkinson's disease (PD). Recent evidence indicates that astrocytes also play pro-inflammatory roles in the central nervous system (CNS) by activation with toll-like receptor (TLR) ligands. T...
Disruption of key GTPase regulators of endocytic recycling compartment does not interfere with soluble antigen crosspresentation in dendritic cells.
Cellular & Molecular Immunology 13(4):554 (2016)
CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish.
International Journal of Cardiology 214:246 (2016)
CXXC-type zinc-finger protein CXXC5 has been reported to be associated with the development of cardiovascular disease. Recently, through signaling pathway screening we found that CXXC5 activated Tgfβ and myocardial differentiation signaling pathways simultaneously. Although the physiological and...
da Vinci robotic versus laparoscopic surgery in rectal cancer: a meta-analysis of postsurgery complications.
International Journal of Colorectal Disease 31(7):1405 (2016)
Fluorescent Carbon Quantum Dots Incorporated into Dye-Sensitized TiO2 Photoanodes with Dual Contributions.
Chemsuschem Chemistry And Sustainability, Energ... 9(12):1498 (2016)
Fluorescent carbon quantum dots (CQDs) were prepared through bottom-up synthesis, which possess excitation wavelength-dependent photoluminescence properties upon excitation by near visible light. For the first time, CQDs were incorporated into N719-sensitized TiO2 photoelectrodes as the electron...
First principles investigation of helium physisorption on an α-Al2O3(0001) surface.
Physical Chemistry Chemical Physics 18(23):15711 (2016)
The interaction of helium with an α-Al2O3(0001) surface was studied by density functional theory (DFT), with consideration of the effects of He-coverage, surface defects, He-coadsorption and van der Waals interaction, respectively. Adsorption energies of helium atoms are very small as expected f...
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
ACS Medicinal Chemistry Letters 7(6):590 (2016)
BMS-711939 (3) is a potent and selective peroxisome proliferator-activated receptor (PPAR) α agonist, with an EC50 of 4 nM for human PPARα and >1000-fold selectivity vs human PPARγ (EC50 = 4.5 μM) and PPARδ (EC50 > 100 μM) in PPAR-GAL4 transactivation assays. Compound 3 also demonstrated excelle...
Infectious clones of the crinivirus cucurbit chlorotic yellows virus are competent for plant systemic infection and vector transmission.
Journal of General Virology 97(6):1458 (2016)
Cucurbit chlorotic yellows virus (CCYV), a recently identified bipartite crinivirus, causes economic losses in cucurbit plants. CCYV is naturally transmitted only by whitefly Bemisia tabaci. Here we constructed full-length cDNA clones of CCYV (RNA1 and RNA2) fused to the T7 RNA polymerase promot...
Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai, China.
Biomedical and Environmental Sciences 29(6):408 (2016)
This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013.
We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire ...
Comparison of laparoscopy-assisted and open radical gastrectomy for advanced gastric cancer: A retrospective study in a single minimally invasive surgery center.
Medicine (Baltimore) 95(25):e3936 (2016)
Laparoscopy-assisted gastrectomy (LAG) has gained international acceptance for the treatment of early gastric cancer (EGC). However, the use of laparoscopic surgery in the management of advanced gastric cancer (AGC) has not attained widespread acceptance. This retrospective large-scale patient s...
Quality evaluation of peony seed oil spray-dried in different combinations of wall materials during encapsulation and storage.
Journal of Food Science and Technology (Mysore) 53(6):2597 (2016)
This study aimed at evaluating the performance of peony seed oil microencapsulated by spray drying during encapsulation and storage. Four different combinations of gum arabic (GA), corn syrup (CS), whey protein concentrate (WPC) and sodium caseinate (CAS) were used to encapsulate peony seed oil....
Effects Of Physical Fitness Training On Psychological Well-being Among College Students With Varied Exercise Experiences: 3778 Board #217 June 4, 8: 00 AM - 9: 30 AM.
Medicine & Science in Sports & Exercise 48(5 Suppl 1):1057 (2016)