1. Sensory detection of food rapidly modulates arcuate feeding circuits.

    Cell 160(5):829 (2015) PMID 25703096

    Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recor...
  2. Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

    Cell 160(5):829 (2015)

    Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report opt...
  3. Sensory detection of food rapidly modulates arcuate feeding circuits.

    Cell 160(5):829 (2015) PMID 25703096

    Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recor...
  4. Piloting the membranolytic activities of peptides with a self-organizing map.

    ChemBioChem 15(15):2225 (2014) PMID 25204788

    Antimicrobial peptides (AMPs) show remarkable selectivity toward lipid membranes and possess promising antibiotic potential. Their modes of action are diverse and not fully understood, and innovative peptide design strategies are needed to generate AMPs with improved properties. We present a de ...
  5. Ba2+- and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells.

    Journal of Physiology 591(Pt 19):4843 (2013) PMID 23940377 PMCID PMC3800458

    Glutamatergic transmission onto oligodendrocyte precursor cells (OPCs) may regulate OPC proliferation, migration and differentiation. Dendritic integration of excitatory postsynaptic potentials (EPSPs) is critical for neuronal functions, and mechanisms regulating dendritic propagation and summat...
  6. Steering target selectivity and potency by fragment-based de novo drug design.

    Angewandte Chemie. International edition in Eng... 52(38):10006 (2013) PMID 24030898

    Kinase inhibitors: Ligand-based de novo design is validated as a viable technology for rapidly generating innovative compounds possessing the desired biochemical profile. The study discloses the discovery of the most selective vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibi...
  7. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory.

    Journal of Neuroscience 33(5):1828 (2013) PMID 23365222

    Acid-sensing ion channel-1a (ASIC1a) is localized in brain regions with high synaptic density and is thought to contribute to synaptic plasticity, learning, and memory. A prominent hypothesis is that activation of postsynaptic ASICs promotes depolarization, thereby augmenting N-methyl-d-aspartat...
  8. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.

    PLoS ONE 8(7):e69019 (2013) PMID 23904909 PMCID PMC3719842

    The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-α (HIF1α) through inhibition of prolyl hydrolase 2 (PHD2) and acti...
  9. Adaptive peptide design.

    CHIMIA International Journal for Chemistry 67(12-13):859 (2013) PMID 24594327

    Computer algorithms help in the identification and optimization of peptides with desired structure and function. We provide an overview of the current focus of our research group in this field, highlighting innovative methods for peptide representation and de novo peptide generation. Our evoluti...
  10. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin.

    Evidence-based Complementary and Alternative Me... 2012:984780 (2012) PMID 22778782 PMCID PMC3388606

    Caffeic acid phenyl ester is distributed wildly in nature and has antidiabetic and cardiovascular protective effects. However, rapid decomposition by esterase leads to its low bioavailability in vivo. In this study, chronic metabolic and cardiovascular effects of oral caffeic acid phenylethyl am...
  11. Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice.

    Journal of Agricultural and Food Chemistry 58(18):10033 (2010) PMID 20804127

    The antihyperglycemic actions of caffeamide derivatives, especially KS370G, in normal ICR, streptozotocin-induced diabetic (T1DM) and diet-induced diabetic (T2DM) mice were investigated in this study. Oral administration of the compound decreased the plasma glucose levels in both normal and diab...
  12. Cell type-specific expression of acid-sensing ion channels in hippocampal interneurons.

    Journal of Neuroscience 30(19):6548 (2010) PMID 20463218

    Acid-sensing ion channels (ASICs), a member of the degenerin/epithelial Na+ channel superfamily, are widely expressed in the mammalian CNS. Accumulating evidence suggests that ASIC current density is higher in GABAergic interneurons than that in glutamatergic pyramidal neurons (PNs) in the hippo...
  13. High-density expression of Ca2+-permeable ASIC1a channels in NG2 glia of rat hippocampus.

    PLoS ONE 5(9) (2010) PMID 20844750 PMCID PMC2937019

    NG2 cells, a fourth type of glial cell in the mammalian CNS, undergo reactive changes in response to a wide variety of brain insults. Recent studies have demonstrated that neuronally expressed acid-sensing ion channels (ASICs) are implicated in various neurological disorders including brain isch...