1. ATM may be a protective factor in endometrial carcinogenesis with the progesterone pathway.

    Tumor Biology 36(3):1529 (2015) PMID 25608836

    The purpose of the study was to explore the role and mechanism of ataxia-telangiectasia mutated (ATM) protein in endometrial carcinogenesis. A reverse-phase protein array (RPPA) was used to analyze the expression of ATM signal pathway proteins in Ishikawa and progesterone-insensitive Ishikawa. A...
  2. Expression and epigenetic regulation of angiogenesis-related factors during dormancy and recurrent growth of ovarian carcinoma.

    Epigenetics 8(12):1330 (2013) PMID 24135786 PMCID PMC3933493

    The initiation of angiogenesis can mark the transition from tumor dormancy to active growth and recurrence. Mechanisms that regulate recurrence in human cancers are poorly understood, in part because of the absence of relevant models. The induction of ARHI (DIRAS3) induces dormancy and autophagy...
  3. Expression and epigenetic regulation of angiogenesis-related factors during dormancy and recurrent growth of ovarian carcinoma.

    Epigenetics 8(12):1330 (2013) PMID 24135786 PMCID PMC3933493

    The initiation of angiogenesis can mark the transition from tumor dormancy to active growth and recurrence. Mechanisms that regulate recurrence in human cancers are poorly understood, in part because of the absence of relevant models. The induction of ARHI (DIRAS3) induces dormancy and autophagy...
  4. Expression and epigenetic regulation of angiogenesis-related factors during dormancy and recurrent growth of ovarian carcinoma.

    Epigenetics 8(12):1330 (2013) PMID 24135786 PMCID PMC3933493

    The initiation of angiogenesis can mark the transition from tumor dormancy to active growth and recurrence. Mechanisms that regulate recurrence in human cancers are poorly understood, in part because of the absence of relevant models. The induction of ARHI (DIRAS3) induces dormancy and autophagy...
  5. Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway.

    Cancer Letters 339(2):279 (2013) PMID 23142288

    Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial ...
  6. Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway

    Cancer Letters 339(2):279 (2013)

    Highlights ► Gankyrin was overexpressed in endometrial carcinoma tissues. ► The depletion of Gankyrin induced endometrial cancer cell proliferation inhibition. ► Gankyrin plays an essential role in estrogen-driven endometrial carcinoma cell proliferation.
  7. Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway.

    Cancer Letters 339(2):279 (2013) PMID 23142288

    Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial ...
  8. Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.

    International Journal of Oncology 43(4):1194 (2013) PMID 23921511 PMCID PMC3981007

    OCT4, a stem cell marker, is overexpressed in several types of human cancer and can induce resistance to chemotherapy and inhibition of apoptosis. We previously demonstrated that human follicle stimulating hormone (FSH) can inhibit ovarian cancer cell apoptosis. However, the role of OCT4 in FSH-...
  9. Corilagin inhibits hepatocellular carcinoma cell proliferation by inducing G2/M phase arrest.

    Cell Biology International 37(10):1046 (2013) PMID 23686743

    Hepatocellular carcinoma (HCC) is one of most common types of malignant tumours. Therefore, it is very important to identify powerful drugs and their antitumour mechanisms. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro. The IC50 values of corilagin ...
  10. Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.

    International Journal of Oncology 43(4):1194 (2013) PMID 23921511 PMCID PMC3981007

    OCT4, a stem cell marker, is overexpressed in several types of human cancer and can induce resistance to chemotherapy and inhibition of apoptosis. We previously demonstrated that human follicle stimulating hormone (FSH) can inhibit ovarian cancer cell apoptosis. However, the role of OCT4 in FSH-...
  11. Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.

    International Journal of Oncology 43(4):1194 (2013) PMID 23921511 PMCID PMC3981007

    OCT4, a stem cell marker, is overexpressed in several types of human cancer and can induce resistance to chemotherapy and inhibition of apoptosis. We previously demonstrated that human follicle stimulating hormone (FSH) can inhibit ovarian cancer cell apoptosis. However, the role of OCT4 in FSH-...
  12. Corilagin inhibits hepatocellular carcinoma cell proliferation by inducing G2/M phase arrest.

    Cell Biology International 37(10):1046 (2013) PMID 23686743

    Hepatocellular carcinoma (HCC) is one of most common types of malignant tumours. Therefore, it is very important to identify powerful drugs and their antitumour mechanisms. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro. The IC50 values of corilagin ...
  13. FSH enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3.

    Endocrine-Related Cancer 20(3):415 (2013) PMID 23580589 PMCID PMC3669658

    Recent studies have suggested that FSH plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis and facilitates neovascularisation. Our previous work has shown that transient recep...
  14. FSH enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3.

    Endocrine-Related Cancer 20(3):415 (2013) PMID 23580589 PMCID PMC3669658

    Recent studies have suggested that FSH plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis and facilitates neovascularisation. Our previous work has shown that transient recep...
  15. Prognostic indicators in WHO 2003 low-grade endometrial stromal sarcoma.

    Histopathology 62(5):675 (2013) PMID 23425310

    Endometrial stromal sarcoma (ESS) has traditionally been divided into low and high grade, but the World Health Organization (WHO, 2003) has changed the definition. Since 2003, many studies have used the old criteria, and few have focused on WHO 2003-defined ESS low grade (ESS-LG). The aim of thi...
  16. Prognostic indicators in WHO 2003 low-grade endometrial stromal sarcoma.

    Histopathology 62(5):675 (2013) PMID 23425310

    Endometrial stromal sarcoma (ESS) has traditionally been divided into low and high grade, but the World Health Organization (WHO, 2003) has changed the definition. Since 2003, many studies have used the old criteria, and few have focused on WHO 2003-defined ESS low grade (ESS-LG). The aim of thi...
  17. A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways.

    BMC Complementary and Alternative Medicine 13:33 (2013) PMID 23410205 PMCID PMC3598193

    Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as a major active component with anti-tumor activity in this herbal medicine. Corilagin is a member of the tannin family that has been discovered in many medicinal plants and ha...
  18. A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways.

    BMC Complementary and Alternative Medicine 13:33 (2013) PMID 23410205 PMCID PMC3598193

    Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as a major active component with anti-tumor activity in this herbal medicine. Corilagin is a member of the tannin family that has been discovered in many medicinal plants and ha...
  19. Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway.

    PLoS ONE 8(5):e63731 (2013) PMID 23667667 PMCID PMC3648479

    Traditional Chinese medicine has gained popularity due to its ability to kill tumor cells. Recently, the apoptotic and anti-angiogenic effects of Trametes robiniophila murr (Huaier) have been investigated. The aim of this study was to investigate its effect on cell mobility and tumor growth in o...
  20. A novel role of proteasomal β1 subunit in tumorigenesis.

    Bioscience Reports 33(4) (2013) PMID 23725357 PMCID PMC3712487

    p27Kip1 is a key cell-cycle regulator whose level is primarily regulated by the ubiquitin-proteasome degradation pathway. Its β1 subunit is one of seven β subunits that form the β-ring of the 20S proteasome, which is responsible for degradation of ubiquitinated proteins. We report here that the ...