Modification of association between prior lung disease and lung cancer by inhaled arsenic: A prospective occupational-based cohort study in Yunnan, China.
Journal of Exposure Science and Environmental E... 26(5):464 (2016)
Arsenic and prior lung diseases have been shown to increase lung cancer risk; however, little is known about their joint effects. The aim of our study was to analyze the joint effects of inhaled arsenic and prior lung diseases on lung cancer risk within a occupational cohort. The interactions of...
Altered expression of long non-coding RNA and mRNA in mouse cortex after traumatic brain injury.
Brain research 1646:589 (2016)
The present study aims to detect the altered lncRNA expression in the mouse cortex after traumatic brain injury (TBI). We also simultaneously detected the altered mRNA profile to further analyze the possible function of lncRNA.
C57BL/6 mice (n=18) were used to construct a controlled cortical imp...
Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways.
International Immunopharmacology 38:104 (2016)
The excessive or prolonged production of inflammatory mediators can result in numerous chronic diseases, such as rheumatoid arthritis, atherosclerosis, diabetes, and cancer. Therefore, for many inflammatory-related diseases, pharmaceutical intervention is required to restrain the excessive relea...
An integrated platform for directly widely-targeted quantitative analysis of feces part II: An application for steroids, eicosanoids, and porphyrins profiling.
Journal of chromatography. A 1460:74 (2016)
Steroids, especially bile acids, along with eicosanoids and porphyrins in feces play pivotal roles for the clinical diagnosis of various diseases. However, their reliable measurement is extensively obstructed by poor stability, structural diversity, broad content ranges, and tedious sample prepa...
An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.
Neuroscience Letters 627:92 (2016)
This study investigated the neuroprotective effects of COG1410, an apoliporotein E (apoE)-derived mimic peptide, against early brain injury (EBI) after subarachnoid hemorrhage (SAH). SAH was induced in C57BL/6J mice (n=68) by endovascular perforation. Mice received intravenous injection of COG14...
Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.
Nature Cell Biology 18(8):851 (2016)
Transforming growth factor-β (TGF-β) induces the expression of Disabled-2 (Dab2), an endocytic adaptor and tumour suppressor, concomitant with the induction of an epithelial-mesenchymal transition (EMT) in mammary epithelial cells. Here we show that following TGF-β-mediated EMT, sustained TGF-β ...
The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model.
Neurobiology of Disease 92(Pt B):137 (2016)
A hallmark of persistent HIV-1 infection in the central nervous system is increased activation of mononuclear phagocytes and surrounding astrogliosis, conferring persistent HIV-induced inflammation. This inflammation is believed to result in neuronal dysfunction and the clinical manifestations o...
Self-healing properties of nanocrystalline materials: a first-principles analysis of the role of grain boundaries.
Physical Chemistry Chemical Physics 18(27):17930 (2016)
Understanding the self-healing mechanisms of defects in nanocrystalline materials is of particular importance for developing structural materials that can support the extended lifetime of components under extremely hostile conditions in nuclear reactors. Since grain boundaries are prevalent in n...
Binder-free graphene and manganese oxide coated carbon felt anode for high-performance microbial fuel cell.
Biosensors and Bioelectronics 81:32 (2016)
A novel anode was developed by coating reduced graphene oxide (rGO) and manganese oxide (MnO2) composite on the carbon felt (CF) surface. With a large surface area and excellent electrical conductivity, this binder-free anode was found to effectively enhance the enrichment and growth of electroc...
An integrated platform for directly widely-targeted quantitative analysis of feces part I: Platform configuration and method validation.
Journal of chromatography. A 1454:58 (2016)
Direct analysis is of great importance to understand the real chemical profile of a given sample, notably biological materials, because either chemical degradation or diverse errors and uncertainties might be resulted from sophisticated protocols. In comparison with biofluids, it is still challe...
A novel pilot-scale stacked microbial fuel cell for efficient electricity generation and wastewater treatment.
Water Research 98:396 (2016)
A novel stacked microbial fuel cell (MFC) which had a total volume of 72 L with granular activated carbon (GAC) packed bed electrodes was constructed and verified to present remarkable power generation and COD removal performance due to its advantageous design of stack and electrode configuratio...
Nitric oxide inhibitory constituents from the barks of Cinnamomum cassia.
Fitoterapia 112:153 (2016)
Six new compounds including one γ-butyrolactone, cinncassin A (1), two tetrahydrofuran derivatives, cinncassins B and C (2, 3), two lignans, cinncassins D and E (4, 5), and one phenylpropanol glucoside, cinnacassoside D (6), together with 14 known lignans (7-20) were isolated from the barks of C...
Solvent-induced desorption of alkanethiol ligands from Au nanoparticles.
Physical Chemistry Chemical Physics 18(23):15927 (2016)
Removing surfactants from a colloidal metal nanoparticle surface is necessary for their realistic applications, and how they could be stripped is a subject of active investigation. Here, we report a solvent-induced desorption of dodecanethiol ligands from the gold nanoparticle surface, and trace...
Insights into bioassessment of marine pollution using body-size distinctness of planktonic ciliates based on a modified trait hierarchy.
Marine Pollution Bulletin 107(1):88 (2016)
Based on a modified trait hierarchy of body-size units, the feasibility for bioassessment of water pollution using body-size distinctness of planktonic ciliates was studied in a semi-enclosed bay, northern China. An annual dataset was collected at five sampling stations within a gradient of heav...
Precipitation hardening and microstructure evolution of the Ti-7Nb-10Mo alloy during aging.
Materials Science and Engineering: C 63:577 (2016)
A biomedical β titanium alloy (Ti-7Nb-10Mo) was designed and prepared by vacuum arc self-consumable melting. The ingot was forged and rolled to plates, followed by quenching and aging. Age-hardening behavior, microstructure evolution and its influence on mechanical properties of the alloy during...
Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia.
Journal of Biological Chemistry 291(22):11689 (2016)
Folliculin (FLCN) is the tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome that predisposes patients to incident of hamartomas and cysts in multiple organs. Its inactivation causes deregulation in the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. However, the u...
Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice.
Journal of Neuroimmunology 294:6 (2016)
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Mol...
Complete Genomic Sequence of Bacteriophage H188: A Novel Vibrio kanaloae Phage Isolated from Yellow Sea.
Current Microbiology 72(5):628 (2016)
Phage H188, a novel Vibrio kanaloae phage, was isolated from the surface water of Yellow Sea. Morphological analysis by transmission electron microscopy reveals that it belongs to the family Myoviridae. Present result suggests that the phage is stable at pH between 4.0 and 12.0. No significant d...
Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.
Journal Of Diabetes 8(3):378 (2016)
The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China.
A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
Responses of Soil Bacterial Communities to Nitrogen Deposition and Precipitation Increment Are Closely Linked with Aboveground Community Variation.
Microbial Ecology 71(4):974 (2016)
It has been predicted that precipitation and atmospheric nitrogen (N) deposition will increase in northern China; yet, ecosystem responses to the interactive effects of water and N remain largely unknown. In particular, responses of belowground microbial community to projected global change and ...