Large-scale qualitative and quantitative characterization of components in Shenfu injection by integrating hydrophilic interaction chromatography, reversed phase liquid chromatography, and tandem mass spectrometry.
Journal of chromatography. A 1407:106 (2015)
It is of great importance to clarify in depth the chemical composition, including qualitative and quantitative aspects, of traditional Chinese medicine (TCM) injection that contains a great number of hydrophilic and hydrophobic ingredients to guarantee its safe medication in clinic. Column-switc...
Homolog-focused profiling of ginsenosides based on the integration of step-wise formate anion-to-deprotonated ion transition screening and scheduled multiple reaction monitoring.
Journal of chromatography. A 1406:136 (2015)
Homolog-focused profiling is a favored option to bridge targeted metabolomics toward non-targeted metabolomics. In current study, an attempt was made for the large-scale ginsenoside-specific analysis in ginseng (G) and American ginseng (AG). When formic acid (0.1%, v/v) was introduced as the mob...
Enhancing the response of microbial fuel cell based toxicity sensors to Cu(II) with the applying of flow-through electrodes and controlled anode potentials.
Bioresource Technology 190:367 (2015)
The application of microbial fuel cell (MFC)-based toxicity sensors to real-world water monitoring is partly impeded by the limited sensitivity. To address this limitation, this study optimized the flow configurations and the control modes. Results revealed that the sensitivity increased by ∼15-...
DNA-caged gold nanoparticles for controlled release of doxorubicin triggered by a DNA enzyme and pH.
Chemical Communications 51(65):12996 (2015)
DNA polyhedron-caged gold nanoparticles (AuNP) were self-assembled using four-point-star DNAs, with three strands hybridizing to each other and the fourth strand attaching to the AuNPs. The DNA-caged AuNPs can work as nanocarriers for doxorubicin, and controlled release behaviour can be triggere...
The Relationship between the Hydrophilicity and Surface Chemical Composition Microphase Separation Structure of Multicomponent Silicone Hydrogels.
Journal of Physical Chemistry B 119(30):9780 (2015)
Three series of multicomponent silicone hydrogels were prepared by the copolymerization of two hydrophobic silicon monomers bis(trimethylsilyloxy) methylsilylpropyl glycerol methacrylate (SiMA) and tris(trimethylsiloxy) 3-methacryloxypropylsilane (TRIS) with three hydrophilic monomers. The surfa...
Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice.
World Journal of Gastroenterology 21(27):8340 (2015)
To investigate the effects of Clostridium butyricum (C. butyricum) on experimental gastric ulcers (GUs) induced by alcohol, restraint cold stress, or pyloric ligation in mice, respectively.
One hundred and twenty mice were randomly allocated into three types of gastric ulcer models (n = 40 each)...
CoOOH Nanosheets with High Mass Activity for Water Oxidation.
Angewandte Chemie. International edition in Eng... 54(30):8722 (2015)
Endowing transition-metal oxide electrocatalysts with high water oxidation activity is greatly desired for production of clean and sustainable chemical fuels. Here, we present an atomically thin cobalt oxyhydroxide (γ-CoOOH) nanosheet as an efficient electrocatalyst for water oxidation. The 1.4 ...
Self-assembling amphiphilic poly(propargyl methacrylate) grafted DNA copolymers into multi-strand helices.
Soft Matter 11(28):5610 (2015)
DNA was covalently grafted onto poly(propargyl methacrylate) (PPMA) via "click" chemistry to synthesize the amphiphilic polymer brush. The PPMA-g-DNA brush could assemble into a primary structure of a nanofiber, which can be compactly spun into a multiple-strand helix in micron-length. The brush...
Association between ABO gene polymorphism (rs505922) and cancer risk: a meta-analysis.
Tumor Biology 36(7):5081 (2015)
Previous studies have showed that ABO blood type is associated with multiple gastrointestinal cancers, including pancreatic cancer. Recently, one single nucleotide polymorphism (SNP) rs505922 in ABO gene has been implicated in susceptibility to pancreatic cancer across different populations, but...
Anti-Neuroinflammatory Effect of MC13, a Novel Coumarin Compound From Condiment Murraya, Through Inhibiting Lipopolysaccharide-Induced TRAF6-TAK1-NF-κB, P38/ERK MAPKS and Jak2-Stat1/Stat3 Pathways.
Journal of Cellular Biochemistry 116(7):1286 (2015)
MC13 is a novel coumarin compound found in Murraya, an economic crop whose leaves are widely used as condiment (curry) in cuisine. The aims of the present study were to investigate the neuroprotective effects of MC13 on microglia-mediated inflammatory injury model as well as potential molecular ...
APOEε4 increases trauma induced early apoptosis via reducing delayed rectifier K(+) currents in neuronal/glial co-cultures model.
Experimental Cell Research 334(2):294 (2015)
Traumatic brain injury (TBI) is a commonly encountered emergency and severe neurosurgical injury. Previous studies have shown that the presence of the apolipoprotein E (APOE) ε4 allele has adverse outcomes across the spectrum of TBI severity. Our objective was to evaluate the effects of APOE all...
Prevalence, knowledge, and treatment of transient ischemic attacks in China.
Neurology 84(23):2354 (2015)
To investigate the prevalence, knowledge, and treatment of TIA in a Chinese adult population.
We conducted a complex, multistage, probability sampling-designed, cross-sectional, nationwide survey of 98,658 Chinese adults in 2010. Possible TIA cases were first identified by symptoms recall or sel...
A rare case with pulmonary and cardiac inflammatory myofibroblastic tumor.
Circulation 131(22):e511 (2015)
Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients.
AIDS 29(9):1113 (2015)
Intracellular nucleoside reverse transcriptase inhibitor (NRTI) concentrations are associated with plasma HIV-1 response. Coadministration of protease inhibitors with NRTIs can affect intracellular concentrations due to protease inhibitor inhibition of efflux transporters. Tenofovir-diphosphate ...
Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction.
Fitoterapia 103:252 (2015)
Three new flavonoid glycosides, (3R)-(+)-isomucronulatol-2'-O-β-D-glucopyranoside (1), (3R)-(-)-isomucronulatol-7-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (2), and (2S)-(-)-7,8-dihydroxylflavanone-4'-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (3), along with eight flavanones (4, 8, 10, 12,...
Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder.
Neuromolecular Medicine 17(2):137 (2015)
Up to date, there has been no molecular signature available in the clinical practice for attention-deficit/hyperactivity disorder (ADHD). To investigate circulating miRNA let-7d significance in ADHD, we investigated serum miRNA let-7d in 35 newly diagnosed ADHD subjects who were randomly selecte...
No Superiority of High-Flexion vs Standard Total Knee Arthroplasty: An Update Meta-Analysis of Randomized Controlled Trials.
The Journal of Arthroplasty 30(6):980 (2015)
This meta-analysis was performed using a Cochrane systematic review approach to examine published data with an aim to clarify whether standard or high flexion prostheses increase the range of knee motion and clinical outcomes. 1778 patients from 17 randomized controlled trials were identified. N...
Five new benzylphenanthrenes from Cremastra appendiculata.
Fitoterapia 103:27 (2015)
Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects ...
Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.
Oncotarget 6(13):11047 (2015)
Chronic liver inflammation precedes the majority of hepatocellular carcinomas (HCC). Here, we explore the connection between chronic inflammation and DNA methylation in the liver at the late precancerous stages of HCC development in Mdr2(-/-) (Mdr2/Abcb4-knockout) mice, a model of inflammation-m...
Risk factors for deep vein thrombosis after orthopedic surgery and the diagnostic value of D-dimer.
Annals of Vascular Surgery 29(4):675 (2015)
This study was prospectively designed to determine the risk factors of deep vein thrombosis (DVT) in patients who underwent different surgeries, and to evaluate the efficacy and accuracy of plasma D-dimer level as a screening test.
From June 2013 to June 2014, 360 consecutive patients undergoing...