Sector mapping method for 3D detached retina visualization.
Computer Methods and Programs in Biomedicine 134:149 (2016)
A new sphere-mapping algorithm called sector mapping is introduced to map sector images to the sphere of an eyeball. The proposed sector-mapping algorithm is evaluated and compared with the plane-mapping algorithm adopted in previous work. A simulation that maps an image of concentric circles to...
The effect of immunosuppressive drug cyclosporine A on myeloid-derived suppressor cells in transplanted mice.
Agents and Actions 65(9):679 (2016)
Myeloid-derived suppressor cells (MDSCs) play important roles in preventing graft rejection. Immunosuppressive drug cyclosporine A (CsA) is widely used in clinics to treat patients with allografts and autoimmune diseases. However, the effect of CsA on CD11b(+)Gr1(+) MDSCs has not been studied.
Protective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage.
Brain research 1646:34 (2016)
Peroxisome-proliferator-activated receptor co-activator-1α (PGC-1α) is a transcriptional co-activator that coordinately regulates genes required for mitochondrial biogenesis, which stimulates mitochondrial activity. It is also a major factor in the up-regulation of antioxidant activities that ar...
Foxo1-mediated inflammatory response after cerebral hemorrhage in rats.
Neuroscience Letters 629:131 (2016)
The forkhead box O (Foxo) family of transcription factors plays a crucial role in cell apoptosis, immune regulation, and tissue development. Foxo1, as the foremost member of the Foxo family, regulates a wide range of molecular signals in many tissues, including tumor, liver, and brain. This stud...
Regulation of neuroendocrine cells and neuron factors in the ovary by zinc oxide nanoparticles.
Toxicology Letters 256:19 (2016)
The pubertal period is an important window during the development of the female reproductive system. Development of the pubertal ovary, which supplies the oocytes intended for fertilization, requires growth factors, hormones, and neuronal factors. It has been reported that zinc oxide nanoparticl...
[Knockdown of PRDX6 in microglia reduces neuron viability after OGD/R injury].
Xi bao yu fen zi mian yi xue za zhi = Chinese j... 32(8):1014 (2016)
Objective To observe the effects of peroxiredoxin 6 (PRDX6) knockdown in the microglia on neuron viability after oxygen-glucose deprivation and reoxygenation (OGD/R). Methods Microglia was treated with lentivirus PRDX6-siRNA and Ca(2+)-independent phospholipase A2 (iPLA2) inhibitor, 1-hexadecyl-...
Alteration of gene expression by zinc oxide nanoparticles or zinc sulfate in vivo and comparison with in vitro data: A harmonious case.
Theriogenology 86(3):850 (2016)
Granulosa cells (GCs) are those somatic cells closest to the female germ cell. GCs play a vital role in oocyte growth and development, and the oocyte is necessary for multiplication of a species. Zinc oxide (ZnO) nanoparticles (NPs) readily cross biologic barriers to be absorbed into biologic sy...
TNFα-induced M-MDSCs promote transplant immune tolerance via nitric oxide.
Klinische Wochenschrift 94(8):911 (2016)
Efficient induction of functional competent myeloid-derived suppressor cells (MDSCs) will be critical for the clinical application of MDSCs to treat autoimmune diseases and to induce transplantation immune tolerance. In the present study, we tried to establish the MDSC induction system with M-CS...
Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015.
The lancet. HIV 3(8):e361 (2016)
Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (...
Update on the mechanisms of homing of adipose tissue-derived stem cells.
Cytotherapy 18(7):816 (2016)
Adipose tissue-derived stem cells (ADSCs), which resemble bone marrow mesenchymal stromal cells (BMSCs), have shown great advantages and promise in the field of regenerative medicine. They can be readily harvested in large numbers with low donor-site morbidity. To date, a great number of preclin...
Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba.
Food & Function 7(6):2870 (2016)
The fruit of Ziziphus jujuba Mill., also called hongzao in Chinese, has a long history of cultivation in China. From the fruit of Z. jujuba, twenty-seven known compounds were isolated and identified as the main constituents of these fruits. They were 3-O-(trans-p-coumaroyl)-alphitolic acid (1), ...
Phosphatase Wip1 Masters IL-17-producing Neutrophil-mediated Colitis in Mice.
Inflammatory Bowel Diseases 22(6):1316 (2016)
Wild-type p53-induced phosphatase 1 (Wip1) is currently believed to be a promising drug target for cancer therapy. Our recent studies showed that deletion of Wip1 remarkably promoted neutrophil inflammatory response. Whether Wip1 is involved in the regulation of inflammatory bowel disease is unk...
Discovery of ERBB3 inhibitors for non-small cell lung cancer (NSCLC) via virtual screening.
Journal of Molecular Modeling 22(6):135 (2016)
As a member of the epidermal growth factor receptor family (EGFR) of receptor tyrosine kinases, ERBB3 plays an important role in mediating cellular growth and differentiation. Recent research works identified that CD74-NRG1 fusions lead to overexpression of the EGF-like domain of NRG1, and thus ...
Impact of Tetrahydropalmatine on the Pharmacokinetics of Probe Drugs for CYP1A2, 2D6 and 3A Isoenzymes in Beagle Dogs.
Phytotherapy Research 30(6):906 (2016)
Tetrahydropalmatine (Tet) exhibit multiple pharmacological activities and is used frequently by clinical practitioners. In this study, we evaluate the in vivo effects of single and repeated oral Tet administrations on CYP1A2, 2D6 and 3A activities in six beagle dogs in a randomized, controlled, ...
Efficacy and Safety of Belimumab Plus Standard Therapy in Patients With Systemic Lupus Erythematosus: A Meta-analysis.
Clinical Therapeutics 38(5):1134 (2016)
The treatment of belimumab plus standard therapy in patients with systemic lupus erythematosus (SLE) has been studied extensively in recent years. Our aim was to estimate the efficacy and safety of this therapy compared with placebo plus standard therapy in patients with SLE.
PubMed, Web of Scie...
Bacillus nitroreducens sp. nov., a humus-reducing bacterium isolated from a compost.
Archives of Microbiology 198(4):347 (2016)
A Gram-staining-positive, facultative anaerobic, motile and rod-shaped bacterium, designated GSS08(T), was isolated from a windrow compost pile and characterized by means of a polyphasic approach. Growth occurred with 0-4 % (w/v) NaCl (optimum 1 %), at pH 6.5-9.5 (optimum pH 7.5) and at 20-45 °C...
Improvement of tolerance to lead by filamentous fungus Pleurotus ostreatus HAU-2 and its oxidative responses.
Chemosphere 150:33 (2016)
Wastewater contaminated with heavy metals is a world-wide concern. One biological treatment strategy includes filamentous fungi capable of extracellular adsorption and intracellular bioaccumulation. Here we report that an acclimated strain of filamentous fungus Pleurotus ostreatus HAU-2 can with...
Robust half-metallic ferromagnetism and curvature dependent magnetic coupling in fluorinated boron nitride nanotubes.
Physical Chemistry Chemical Physics 18(17):12307 (2016)
The fluorinated boron nitride (F-BN) nanostructures are found to be fully spin polarized and half-metallic by means of first-principles calculations based on the Heyd-Scuseria-Ernzerhof hybrid functional. It is found that the full spin polarization and 1 μB local moment in F-BN nanotubes are ind...
Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.
Cell Stem Cell 18(4):456 (2016)
Mammals have partially lost the extensive regenerative capabilities of some vertebrates, possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. Here, we show that deleting the SWI/SNF component Arid1a substantially improves mammalian regeneration. Arid1a e...
Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase and tensin homologue (PTEN)/AKT pathways.
Reproduction, Fertility and Development 28(6):700 (2016)
The growth of oocytes and the development of follicles require certain pathways involved in cell proliferation and survival, such as the phosphatidylinositol 3-kinase (PI3K) pathway and the Notch signalling pathway. The aim of the present study was to investigate the interaction between Notch an...