1. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.

    EBioMedicine 2(11):1751 (2015) PMID 26870800 PMCID PMC4740320

    Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selec...
  2. Immunological analysis of a patient with hepatitis B virus (HBV) reactivation after bone marrow transplantation.

    Internal Medicine (Tokyo, 1992) 54(10):1213 (2015) PMID 25986258

    Patients with resolved hepatitis B virus (HBV) infection undergoing chemo- or immunosuppressive therapy are at potential risk for HBV reactivation. To determine whether the host immune response contributes to liver injury, we performed an immunological analysis of a patient with HBV reactivation...
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  3. Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells.

    Infection and Immunity 82(11):4487 (2014) PMID 25114116 PMCID PMC4249307

    Indoleamine 2,3-dioxygenase-1 (Ido), which catalyzes the first and limiting step of tryptophan catabolism, has been implicated in immune tolerance. However, the roles of Ido in systemic bacterial infection are complicated and remain controversial. To explore this issue, we examined the roles of ...
  4. Synthesis of hydroxycinnamoyl β-d-xylopyranosides and evaluation of their antioxidant properties

    Carbohydrate Research 388:138 (2014) PMID 24642363

    Synthesis of hydroxycinnamoyl β-d-xylopyranosides and evaluation of their antioxidant properties.
  5. A case of malignant melanoma simultaneously found in the lung and small intestine.

    Clinical Journal of Gastroenterology 6(1):25 (2013) PMID 26181400

    Metastatic melanoma in the small bowel is a common cause of secondary intestinal tumors. We present a case of a 77-year-old man with melena resulting from melanoma in the small bowel that was simultaneously found with malignant melanoma in the lung. Abdominal contrast-enhanced computed tomograph...
  6. Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.

    Journal of Clinical Investigation 123(2):834 (2013) PMID 23298833 PMCID PMC3561803

    Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). These sphingolipids regulate carcinogenesis and proliferation, survival, and apoptosis of cancer cells. However, the role of ASM in host defense against liver metastasis...
  7. Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.

    PLoS ONE 8(6):e65251 (2013) PMID 23755201 PMCID PMC3670853

    Tumor necrosis factor (TNF)-α, which is a mediator of hepatotoxicity, has been implicated in liver fibrosis. However, the roles of TNF-α on hepatic stellate cell (HSC) activation and liver fibrosis are complicated and remain controversial. To explore this issue, the role of TNF-α in cholestasis-...
  8. Synthesis of glycosyl ferulate derivatives by amine-promoted glycosylation with regioselective hydrolysis using Novozym 435 and evaluation of their antioxidant properties.

    Carbohydrate Research 359:11 (2012) PMID 22925758

    Various glycosyl ferulates were efficiently synthesized from 2,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (TAGB) with amine by amine-promoted glycosylation without using heavy metal. The resulted acetylated glycosyl ferulates with acetoxyl groups at C-2, C-3 and C-4 were regioselectively deac...
  9. Involvement of KRAS G12A mutation in the IL-2-independent growth of a human T-LGL leukemia cell line, PLT-2.

    Nagoya journal of medical science 74(3-4):261 (2012) PMID 23092099 PMCID PMC4831235

    Cytokine-dependent cell lines have been used to analyze the cytokine-induced cellular signaling and the mechanism of oncogenesis. In the current study, we analyzed MOTN-1 and PLT-2 cell lines established from different stages of a T-cell large granular lymphocyte leukemia patient (Daibata et al....
  10. L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice.

    Journal of Immunology 188(8):3980 (2012) PMID 22422885

    The activity of IDO that catalyzes the degradation of tryptophan (Trp) into kynurenine (Kyn) increases after diseases caused by different infectious agents. Previously, we demonstrated that IDO has an important immunomodulatory function in immune-related diseases. However, the pathophysiological...
  11. Adult intussusception of the descending colon due to inflammatory myofibroblastic proliferation.

    Clinical Journal of Gastroenterology 5(1):74 (2012) PMID 26181880

    We present a case of an asymptomatic 70-year-old man with intussusception of the descending colon due to inflammatory myofibroblastic proliferation. Abdominal ultrasound examination showed a hypoechoic mass, 32 × 19 mm in size, accompanied by intussusception in the descending colon, and power Do...
  12. High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice.

    Scientific reports 2:367 (2012) PMID 22509465 PMCID PMC3326635

    Secondary bacterial infection in humans is one of the pathological conditions requiring clinical attention. In this study, we examined the effect of lipopolysaccharide (LPS) on encephalomyocarditis virus (EMCV) infected mice. All mice inoculated with EMCV at 5 days before LPS challenge died with...
  13. The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments.

    Anticancer Research 32(1):31 (2012) PMID 22213285

    The tumor microenvironment (TME) has an important influence on tumor progression. For example, we have discovered that passenger stromal cells are necessary for metastasis. In this report, we describe six different cyan fluorescent protein (CFP) multicolor TME nude mouse models. The six differen...
  14. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin.

    Journal of Biological Chemistry 286(40):34800 (2011) PMID 21841000 PMCID PMC3186417

    Nonalcoholic fatty liver disease is one of the most common liver diseases. L-tryptophan and its metabolite serotonin are involved in hepatic lipid metabolism and inflammation. However, it is unclear whether L-tryptophan promotes hepatic steatosis. To explore this issue, we examined the role of L...
  15. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.

    FASEB Journal 25(4):1133 (2011) PMID 21163859 PMCID PMC3058702

    Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). Because sphingolipids regulate AKT activation, we investigated the role of ASM in hepatic glucose and lipid metabolism. Initially, we overexpressed ASM in the livers of ...
  16. Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.

    Journal of Cellular Biochemistry 112(3):949 (2011) PMID 21328469

    The tumor microenvironment (TME) is critical for tumor growth and progression. However, the formation of the TME is largely unknown. This report demonstrates a color-coded imaging model in which the development of the TME can be visualized. In order to image the TME, a green fluorescent protein ...
  17. Acid Sphingomyelinase Regulates Glucose and Lipid Metabolism in Hepatocytes

    Gastroenterology 140(5):S (2011)

  18. Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.

    Journal of Cellular Biochemistry 111(4):1035 (2010) PMID 20672309

    In this study, we demonstrate that the differential behavior, including malignancy and chemosensitivity, of cancer stem-like and non-stem cells can be simultaneously distinguished in the same tumor in real time by color-coded imaging. CD133(+) Huh-7 human hepatocellular carcinoma (HCC) cells wer...
  19. Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.

    Journal of Immunology 185(8):4554 (2010) PMID 20844202

    IDO converts tryptophan to l-kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, we examined the effect of IDO in α-galactosylceramide (α-GalCer)-induced hepatitis. The increase in IDO expression in the liver of wild-type (W...
  20. The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.

    Journal of Immunology 185(6):3305 (2010) PMID 20693424

    Indoleamine 2,3-dioxygenase, the L-tryptophan-degrading enzyme, plays a key role in the powerful immunomodulatory effects on several different types of cells. Because modulation of IDO activities after viral infection may have great impact on disease progression, we investigated the role of IDO ...