Practice guideline update summary: Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache: Report of the Guideline Development Subcommittee of the American Academy of Neurology.
Neurology 86(19):1818 (2016)
To update the 2008 American Academy of Neurology (AAN) guidelines regarding botulinum neurotoxin for blepharospasm, cervical dystonia (CD), headache, and adult spasticity.
We searched the literature for relevant articles and classified them using 2004 AAN criteria.
Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.
Muscle & Nerve 53(2):165 (2016)
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Journal of Neurovirology 19(3):209 (2013)
Emerging evidence suggests that CNS injury and neurocognitive impairment persist in the setting of chronic HIV infection and combination antiretroviral therapy (CART). Yet, whether neurological injury can progress in this setting remains uncertain. Magnetic resonance spectroscopy and neurocognit...
Effects of noninvasive ventilation on sleep outcomes in amyotrophic lateral sclerosis.
Journal of clinical sleep medicine : JCSM : off... 9(4):345 (2013)
The objective was to study the effects on noninvasive ventilation on sleep outcomes in patient with ALS, specifically oxygenation and overall sleep quality.
Patients with ALS who met criteria for initiation of NIV were studied with a series of 2 home PSG studies, one without NIV and a follow-up ...
Evidence-based guideline: IV immunoglobulin in the treatment of neuromuscular disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Neurology 79(13):1411; author reply 1411 (2012)
Continuum: Lifelong Learning in Neurology 18(1):85 (2012)
The immune-mediated neuropathies are an important group of treatable neuropathies that often lead to severe neurologic disability. This review guides clinicians in the recognition and treatment of these disorders.
Advances include new insights in classification and new treatment paradigms in man...
Cost comparison between the atraumatic and cutting lumbar puncture needles.
Neurology 78(2):109 (2012)
The aim of this study was to determine which type of spinal needle is preferred from a cost perspective, taking into account costs of the spinal needle and treatment of postlumbar puncture headache.
A decision-analytic model was created to determine the cost of diagnostic lumbar punctures using ...
Analysis of continuous diaphragm electromyographic signal: results from a patient with amyotrophic lateral sclerosis.
Muscle & Nerve 43(6):801 (2011)
Analysis of continuous diaphragm electromyography (dEMG) has not been well studied. We describe a system of analyzing continuous dEMG using implanted electrodes.
dEMG signal was acquired via two pairs of electrodes near the diaphragm motor points. Raw bursts of dEMG signal were compared to exter...
End-stage cardiac disease as an initial presentation of systemic myopathies: case series and literature review.
Journal of child neurology 25(11):1382 (2010)
Life-threatening cardiomyopathy is associated with certain systemic myopathies and usually presents as an end-stage progression of the disease. However, cardiac symptoms can sometimes precede muscle weakness. The authors reviewed medical records from 2003 to 2008 on patients attending their neur...
Chemotherapy-related polyneuropathy may deteriorate quality of life in patients with B-cell lymphoma.
Quality of Life Research 19(8):1097 (2010)
This prospective study was performed to evaluate the effect of chemotherapy-related neurotoxicity on quality of life (QOL) of patients with lymphoma.
Thirty-two patients with diffuse large B-cell or follicular lymphoma without prior evidence of neuropathy were enrolled. Patients underwent the ev...
Utility of electrodiagnostic testing in evaluating patients with lumbosacral radiculopathy: An evidence-based review.
Muscle & Nerve 42(2):276 (2010)
This is an evidence-based review of electrodiagnostic (EDX) testing of patients with suspected lumbosacral radiculopathy to determine its utility in diagnosis and prognosis. Literature searches were performed to identify articles applying EDX techniques to patients with suspected lumbosacral rad...
Driving with polyneuropathy.
Muscle & Nerve 41(3):324 (2010)
Polyneuropathy may result in pain, numbness, and weakness, which may in turn affect driving ability. Medications used to treat neuropathic pain may alter cognition, which may further affect driving. Although such impairments have engendered questions about the driving safety in this group of pat...
Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology.
Neurology 74(8):691 (2010)
A Food and Drug Administration advisory in 2006 warned against the off-label use of quinine sulfate and its derivatives in the treatment of muscle cramps. Physicians are faced with a difficult scenario in choosing a treatment regimen for patients with muscle cramps. This American Academy of Neur...
The value of electromyography: toward an evidence-based use of electrodiagnostic testing.
Muscle & Nerve 40(2):171 (2009)
Disorders of the trigeminal system.
Seminars in Neurology 29(1):36 (2009)
The management of patients with trigeminal system dysfunction requires an understanding of the system's complex anatomy, which extends from peripheral nerve endings, through the skull base, cavernous sinus (V1, V2 only), and trigeminal ganglion, to the intraaxial nuclei, tracts, and cerebral cor...
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.
Nature Medicine 13(11):1359 (2007)
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impa...
Action at a distance: a lumbar spine tumor presenting as trigeminal neuralgia.
Clinical Neurology and Neurosurgery 108(8):806 (2006)
Trigeminal neuralgia (TN) is often secondary to an underlying structural cause, frequently compression of the fifth nerve root by an ectatic artery. Here we describe a case of a 36-year-old woman with symptoms of TN who was found to have severe communicating hydrocephalus. Further investigation ...
Practice Advisory: utility of surgical decompression for treatment of diabetic neuropathy: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Neurology 66(12):1805 (2006)
Surgical decompression at the site of anatomic narrowing has been promoted as an alternative treatment for patients with symptomatic diabetic neuropathy. Systematic review of the literature revealed only Class IV studies concerning the utility of this therapeutic approach. Given the current evid...
High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies.
Muscle & Nerve 33(3):433 (2006)
We describe a 48-year-old woman with seronegative myasthenia gravis (MG) and high-titer of anti-MuSK antibody. She had severe bulbar and respiratory weakness with minimal limb weakness for 2 years. Her disease responded poorly to all the conventional immunosuppressive regimens. Treatment with im...
Use of serum prolactin in diagnosing epileptic seizures: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Neurology 65(5):668 (2005)
The purpose of this article is to review the use of serum prolactin assay in epileptic seizure diagnosis.
The authors identified relevant studies in multiple databases and reference lists. Studies that met inclusion criteria were summarized and rated for quality of evidence, and the results were...