1. Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.

    American Journal of Epidemiology 184(4):295 (2016) PMID 27466075

    Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 d...
  2. Optimal cut-off levels of obesity indices by different definitions of metabolic syndrome in a southeast rural Chinese population.

    Journal Of Diabetes Investigation 7(4):594 (2016) PMID 27181602 PMCID PMC4931211

    The aim of the present study was to compare the cut-off values and prediction effect of different obesity indices by different definitions of metabolic syndrome (MetS) in Zhejiang Province of China. We carried out a cross-sectional survey of 10,100 individuals (age 40 years and older) in Jiashan...
  3. Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis.

    Diabetes 65(6):1731 (2016) PMID 26953161

    We aimed to explore the causal association between type 2 diabetes (T2D) and increased arterial stiffness. We performed a Mendelian randomization (MR) analysis in 11,385 participants from a well-defined community study in Shanghai during 2011-2013. We genotyped 34 T2D-associated common variants ...
  4. Curbing the obesity epidemic in China.

    The lancet. Diabetes & endocrinology 4(6):470 (2016) PMID 27133171

  5. Bisphenol A Promotes Adiposity and Inflammation in a Nonmonotonic Dose-response Way in 5-week-old Male and Female C57BL/6J Mice Fed a Low-calorie Diet.

    Endocrinology 157(6):2333 (2016) PMID 27145005

    A growing body of epidemiological research show that Bisphenol A (BPA) is positively correlated with obesity and metabolic disorders. However, the mechanisms of BPA on adiposity remain largely unknown. In this study, we found that 5-week-old male and female C57BL/6J mice exposed to four dosages ...
  6. Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.

    Journal Of Diabetes 8(3):378 (2016) PMID 25940519

    The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China. A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
  7. Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men.

    Journal Of Diabetes 8(3):434 (2016) PMID 25991060

    The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. A population-based cross-sectional study was per...
  8. Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.

    EBioMedicine 6:162 (2016) PMID 27211558 PMCID PMC4856750

    Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished. We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined commu...
  9. Obesity and peripheral arterial disease: A Mendelian Randomization analysis.

    Atherosclerosis 247:218 (2016) PMID 26945778

    Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomiz...
  10. Insulin Resistance is Associated With Total Bile Acid Level in Type 2 Diabetic and Nondiabetic Population: A Cross-Sectional Study.

    Medicine (Baltimore) 95(10):e2778 (2016) PMID 26962776

    Bile acid metabolism was reported to be involved in glucose metabolism homeostasis. However, the exact relationship between bile acid and glucose metabolism as well as insulin sensitivity is not clarified. Therefore, we sought to investigate the association between insulin sensitivity and hyperb...
  11. Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.

    Obesity 24(3):703 (2016) PMID 26833544

    To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and mea...
  12. Association of Serum Fetuin-A Levels With the Risk of Albuminuria in Middle-Aged and Elderly Chinese.

    Journal of Clinical Endocrinology & Metabolism 101(3):1235 (2016) PMID 26756112

    Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities. The association between fetuin-A and albuminuria has not been investigated in a prospective cohort. The objective of the study was to prospectively investigate whether serum fetuin-A levels were associated with...
  13. Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis.

    Diabetologia 59(2):307 (2016) PMID 26515422

    Glucokinase regulatory protein gene (GCKR) variant rs780092 is a novel genetic variant associated with serum triacylglycerol (TG) identified in a genome-wide association study in East Asians. We aimed to investigate associations of rs780092 with incident type 2 diabetes and dyslipidaemia, and th...
  14. Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study.

    The lancet. Diabetes & endocrinology 4(2):125 (2016) PMID 26776861

    Little is known about the cardiometabolic health of internal migrant workers in China. We aimed to examine the prevalence of diabetes-related cardiometabolic risk factors in this large, but little-studied population. We did this national surveillance study within the Chinese Center for Disease C...
  15. Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism.

    Journal of Clinical Endocrinology & Metabolism 101(1):143 (2016) PMID 26523527

    Epidemiology studies showed inconsistent results regarding the relationship between bisphenol A (BPA) exposure and risk of type 2 diabetes (T2D). This study sought to prospectively investigate associations of BPA with incident T2D risk and the longitudinal changes in glycemic traits, particularl...
  16. Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study.

    Journal of the American Heart Association Cardi... 5(7) (2016) PMID 27451464

    Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear. This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10-year Framingham risk for c...
  17. Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population.

    Journal of Atherosclerosis and Thrombosis 23(2):216 (2016) PMID 26423715

    Increased carotid artery intima media thickness (C-IMT) is an early feature of atherosclerosis. It has been reported to be altered in patients with thyroid dysfunction, and the evidence is still controversial. The present study aimed to explore the relationship between C-IMT and possible variati...
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  18. Risk of all-cause mortality and cardiovascular disease associated with secondhand smoke exposure: a systematic review and meta-analysis.

    International Journal of Cardiology 199:106 (2015) PMID 26188829

    Emerging studies have assessed the association between secondhand smoke (SHS) exposure and cardiovascular disease (CVD) as well as all-cause mortality. However, findings were not consistent due to the heterogeneity of study characteristics. PubMed and Embase were searched through May 2014 for pr...
  19. Prevalence and trends in overweight and obesity among Chinese adults in 2004–10: data from three nationwide surveys in China

    The Lancet 386:S77 (2015)

    Background Obesity has become a global epidemic and is a common risk factor for many chronic diseases. Few data for the prevalence and trends in overweight and obesity in Chinese adults have been obtained over the past decade. We aimed to estimate changes in the prevalence of...
  20. Prevalence, awareness, treatment, and control of diabetes in relation to hypertension status in Chinese adults: a nationwide cross-sectional survey

    The Lancet 386:S55 (2015)

    Background Previous studies have shown that hypertension is an important risk factor for diabetes, and the coexistence of hypertension and diabetes can substantially increase morbidity and mortality of cardiovascular disease. The aim of this study was to estimate the prevalen...