1. Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program.

    PMID 27436464

    This study investigated the antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolates causing adult community-acquired respiratory tract infections (CARTIs) in China. A multicentre resistance surveillance study (CARTIPS) investigating 1...
  2. LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer.

    Breast Cancer Research and Treatment 154(3):473 (2015) PMID 26564482 PMCID PMC4854534

    Long non-coding RNAs (lncRNAs) are a class of newly recognized DNA transcripts that have diverse biological activities. Dysregulation of lncRNAs may be involved in many pathogenic processes including cancer. Recently, we found an intergenic lncRNA, LINC00472, whose expression was correlated with...
  3. [Analysis of pathogen spectrum and resistance of clinical common organisms causing bloodstream infections, hospital-acquired pneumonia and intra-abdominal infections from thirteen teaching hospitals in 2013].

    Zhonghua Yixue Zazhi 95(22):1739 (2015) PMID 26704158

    To investigate the spectrum and antimicrobial resistance of major pathogensthat causing nosocomial infections in China, 2013. Nosocomial cases as well as pathogens causing bloodstream infections (BSI), hospital-acquired pneumonia (HAP) and intra-abdominal infections (IAI) from 13 teaching hospit...
  4. Genetic characterisation of clinical Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline: Role of the global regulator RamA and its local repressor RamR.

    International Journal of Antimicrobial Agents 45(6):635 (2015) PMID 25681067

    Laboratory-derived Klebsiella pneumoniae mutants demonstrated that the ramA locus mediated low-level tigecycline resistance. The aim of this study was to elucidate the underlying mechanisms of tigecycline resistance in clinical K. pneumoniae isolates. In total, 106 isolates with tigecycline MICs...
  5. In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China.

    Japanese Journal of Infectious Diseases 68(4):263 (2015) PMID 25672407

    To evaluate the in vitro antimicrobial activities of biapenem, arbekacin, and cefminox against different gram-negative bacterial isolates in China, a total of 100 non-duplicated Escherichia coli, 100 Acinetobacter baumannii, 100 Pseudomonas aeruginosa, and 99 Klebsiella pneumoniae isolates were ...
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  6. Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk.

    Scientific reports 5:15582 (2015) PMID 26498156 PMCID PMC4620445

    Prolonged estrogen exposure is believed to be the major cause of endometrial cancer. As possible markers of estrogen exposure, various menstrual and reproductive features, e.g., ages at menarche and menopause, are found to be associated with endometrial cancer risk. In order to assess their comb...
  7. Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.

    PLoS ONE 10(8):e0136246 (2015) PMID 26287798 PMCID PMC4546117

    To investigate the biologic relevance and clinical implication of genes involved in multiple gene expression signatures for breast cancer prognosis, we identified 16 published gene expression signatures, and selected two genes, MAD2L1 and BUB1. These genes appeared in 5 signatures and were invol...
  8. [Resistance surveillance of major pathogens for adult community-acquired respiratory tract infections in China: a multicenter study 2012].

    Zhonghua jie he he hu xi za zhi = Zhonghua jieh... 38(1):18 (2015) PMID 25791651

    To investigate antimicrobial resistance among pathogens responsible for adult community-acquired respiratory tract infections from 11 hospitals of China. From January to December 2012, a total of 599 strains causing adult community-acquired respiratory tract infection were collected from 11 hosp...
  9. In vitro antimicrobial activity of the novel oxazolidinone tedizolid and comparator agents against Staphylococcus aureus and linezolid-resistant Gram-positive pathogens: a multicentre study in China.

    International Journal of Antimicrobial Agents 44(3):276 (2014) PMID 25108879

  10. Novel NDM-9 metallo-β-lactamase identified from a ST107 Klebsiella pneumoniae strain isolated in China.

    International Journal of Antimicrobial Agents 44(1):90 (2014) PMID 24913967

  11. Non-linear time series analysis on flow instability of natural circulation under rolling motion condition

    Annals of Nuclear Energy 65:1 (2014)

    • Natural circulation flow instabilities in rolling motion are studied. • The method of non-linear time series analysis is used. ...
  12. Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors.

    Journal of Molecular Histology 45(1):11 (2014) PMID 23974864 PMCID PMC4544579

    Endogenous estrogen deficiency usually causes the systemic osteoporosis including the jaw bones. However, it remains unclear whether estrogen deficiency can affect the tooth mineralization. In this study, the classical osteoporotic rat model was established via the ovariectomy, which was subsequ...
  13. In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 Gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China.

    Antimicrobial Agents and Chemotherapy 58(3):1774 (2014) PMID 24342639 PMCID PMC3957831

    Ceftazidime-avibactam, aztreonam-avibactam, and comparators were tested by reference broth microdilution against 372 nonrepetitive Gram-negative bacilli (346 unselected plus 26 selected meropenem-nonsusceptible Enterobacteriaceae isolates) collected from 11 teaching hospitals in China in 2011 an...
  14. In vitro antibacterial activities of two novel oral antibiotics, tebipenem and cefditoren, and other comparators against community-acquired respiratory tract infection-associated bacterial pathogens: a multicentre study in China.

    International Journal of Antimicrobial Agents 43(1):92 (2014) PMID 24183753

  15. Molecular characteristics of carbapenemase-producing Enterobacteriaceae in China from 2008 to 2011: predominance of KPC-2 enzyme.

    Diagnostic Microbiology and Infectious Disease 78(1):63 (2014) PMID 24211218

    Among 228 carbapenem-nonsusceptible Enterobacteriaceae isolated in China, 65 were carbapenemase-producing Enterobacteriaceae (CPE). Among them, 41, 22, 1, and 1 produced KPC-2, IMP-4, IMP-8, and IMP-1, respectively. KPC-2-producing CPE showed higher resistance than IMP-4-producing ones. Furtherm...
  16. G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells.

    Cell Communication and Signaling 12:10 (2014) PMID 24521094 PMCID PMC3937014

    In a classic model, G(i)α proteins including G(i1)α, G(i2)α and G(i3)α are important for transducing signals from G(i)α protein-coupled receptors (G(i)αPCRs) to their downstream cascades in response to hormones and neurotransmitters. Our previous study has suggested that G(i1)α, G(i2)α and G(i3)...
  17. Suppression of C6 gliomas via application of rat hyperplasia gene.

    International Journal of Biological Markers 29(4):e411 (2014) PMID 25362936

    Among all neurological tumors, tumor incidence of the neuroepithelial tissue is the highest, where 50% are gliomas. Treatment for gliomas has traditionally included surgery and adjuvant therapy. With advancements in medicine, gene therapy has entered the clinical setting, in which control of tum...
  18. Prospective multicenter study of pathogen distributions in early-onset and late-onset hospital-acquired pneumonia in china.

    Antimicrobial Agents and Chemotherapy 57(12):6404 (2013) PMID 24041893 PMCID PMC3837894

  19. Dental pulp stem cells from traumatically exposed pulps exhibited an enhanced osteogenic potential and weakened odontogenic capacity.

    Archives of Oral Biology 58(11):1709 (2013) PMID 24112738

    Traumatic pulp exposure can bring about some permanent damages to tooth tissues including dental pulps. This study was designed to evaluate the effects of traumatic pulp exposure on the osteo/odontogenic capacity of dental pulp stem cells (DPSCs). Rat incisors were artificially fractured and den...
  20. Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms.

    International Journal of Antimicrobial Agents 42(4):317 (2013) PMID 23880167

    Genetic characterisation of linezolid-resistant Gram-positive cocci in a multicentre study in China has not been reported previously. To study the mechanism underlying the resistance of linezolid-resistant isolates, nine Enterococcus faecalis, one Enterococcus faecium and three Staphylococcus co...