1. Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability.

    Thrombosis and Haemostasis 113(6):1300 (2015) PMID 25790442

    Haemophilia A and B are characterised by a life-long bleeding predisposition, and several lines of evidence suggest that risks of atherothrombotic events may also be reduced. Establishing a direct correlation between coagulation factor levels, thrombotic risks and bleeding propensity has long be...
  2. The Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families in Populus trichocarpa: gene structure, gene expression,phylogenetic analysis and evolution.

    Journal of Genetics 94(2):317 (2015) PMID 26174682

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  3. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.

    Nucleic Acids Research 43(10):5081 (2015) PMID 25897119 PMCID PMC4446437

    Hypoxia-inducible factor (HIF)-1α and HIF-2α are the main regulators of cellular responses to hypoxia. Post-translational modifications of HIF-1α and 2α are necessary to modulate their functions. The methylation of non-histone proteins by Set7, an SET domain-containing lysine methyltransferase, ...
  4. Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis.

    Journal of Immunology 194(9):4489 (2015) PMID 25810397

    Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disord...
  5. CEACAM6 promotes tumor angiogenesis and vasculogenic mimicry in gastric cancer via FAK signaling

    Biochimica et Biophysica Acta (BBA) - Molecular... 1852(5):1020 (2015)

    CEACAM6 is a member of glycosylphosphatidylinositol-linked immunoglobulin superfamily that is implicated in a variety of human cancers. In our previous study, we reported that CEACAM6 was overexpressed in gastric cancer tissues and promoted cancer metastasis. The purpose of this study ...
  6. Folate-polyethyleneimine functionalized mesoporous carbon nanoparticles for enhancing oral bioavailability of paclitaxel

    International Journal of Pharmaceutics 484(1-2):207 (2015)

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  7. Folate-polyethyleneimine functionalized mesoporous carbon nanoparticles for enhancing oral bioavailability of paclitaxel

    International Journal of Pharmaceutics 484(1-2):207 (2015)

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  8. Comparison of two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma.

    World Journal of Gastroenterology 21(16):4875 (2015) PMID 25945000 PMCID PMC4408459

    To compare two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma. Thirty New Zealand rabbits were randomly divided into two groups: A and B. Group A was assigned a traditional laparotomy method (embedding tumor fragments directly into the liver with tweezers). Group B was subj...
  9. Significantly improved electrochemical hydrogen storage properties of magnesium nickel hydride modified with nano-nickel

    Journal of Power Sources 280:132 (2015)

    Magnesium nickel hydride (Mg2NiH4) used as negative electrode material in nickel-metal hydride (Ni-MH) secondary battery is modified by nano-nickel via mechanical milling. In this paper, we systematically investigate the microstructure and electrochemical properties of the modified sys...
  10. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells.

    Cell Cycle 14(5):761 (2015) PMID 25590866

    Cordycepin, an adenosine analog derived from Cordyceps militaris has been shown to exert anti-tumor activity in many ways. However, the mechanisms by which cordycepin contributes to the anti-tumor still obscure. Here our present work showed that cordycepin inhibits cell growth in NB-4 and U937 c...
  11. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells.

    Cell Cycle 14(5):761 (2015) PMID 25590866

    Cordycepin, an adenosine analog derived from Cordyceps militaris has been shown to exert anti-tumor activity in many ways. However, the mechanisms by which cordycepin contributes to the anti-tumor still obscure. Here our present work showed that cordycepin inhibits cell growth in NB-4 and U937 c...
  12. UPLC/Q-TOF-MS analysis of iridoid glycosides and metabolites in rat plasma after oral administration of Paederia scandens extracts.

    Chinese Journal of Natural Medicines 13(3):215 (2015) PMID 25835366

    A rapid and validated UPLC-MS method was developed for investigating the absorbed components of Paederia scandens (Lour.) Merrill (P. scandensy) in rat plasma. The bioactive constituents in plasma samples from rats administrated orally with P. scandens extract were analyzed by Ultra-performance ...
  13. Inhaled budesonide prevents acute mountain sickness in young chinese men.

    The Journal of Emergency Medicine 48(2):197 (2015) PMID 25294611

    Oral glucocorticoids can prevent acute mountain sickness (AMS). Whether inhaled budesonide (BUD) can prevent AMS remains unknown. Our aim was to investigate the effectiveness of BUD in AMS prevention. Eighty subjects were randomly assigned to receive budesonide (BUD, inhaled), procaterol tablet ...
  14. In situ amplification of intracellular microRNA with MNAzyme nanodevices for multiplexed imaging, logic operation, and controlled drug release.

    ACS Nano 9(1):789 (2015) PMID 25525669

    MicroRNAs (miRNAs), as key regulators in gene expression networks, have participated in many biological processes, including cancer initiation, progression, and metastasis, indicative of potential diagnostic biomarkers and therapeutic targets. To tackle the low abundance of miRNAs in a single ce...
  15. Partitioning of PAHs in pore water from mangrove wetlands in Shantou, China

    Ecotoxicology and Environmental Safety 111:42 (2015)

    To investigate the trend of selected polycyclic aromatic hydrocarbons (PAHs) partitioning, fifteen pore water samples collected from the sediments of three mangrove wetlands were analyzed, and the partition coefficients and the partition model for the PAHs were determined by the correl...
  16. Partitioning of PAHs in pore water from mangrove wetlands in Shantou, China

    Ecotoxicology and Environmental Safety 111:42 (2015)

    To investigate the trend of selected polycyclic aromatic hydrocarbons (PAHs) partitioning, fifteen pore water samples collected from the sediments of three mangrove wetlands were analyzed, and the partition coefficients and the partition model for the PAHs were determined by the correl...
  17. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish.

    Journal of Hematology & Oncology 8(1):15 (2015) PMID 25886310 PMCID PMC4372312

    DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development and diverse biological processes, including maintenance of hematopoietic stem and pr...
  18. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.

    Nature Communications 6:6304 (2015) PMID 25710614 PMCID PMC4340086

    Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the...
  19. Partitioning of PAHs in pore water from mangrove wetlands in Shantou, China.

    Ecotoxicology and Environmental Safety 111:42 (2015) PMID 25450913

    To investigate the trend of selected polycyclic aromatic hydrocarbons (PAHs) partitioning, fifteen pore water samples collected from the sediments of three mangrove wetlands were analyzed, and the partition coefficients and the partition model for the PAHs were determined by the correlation betw...
  20. Synthesis of HDI/IPDI hybrid isocyanurate and its application in polyurethane coating

    Progress in Organic Coatings 78:225 (2015)

    A hybrid isocyanurate was prepared by trimerization of HDI and IPDI, and the results identified the favorable linear relationship between the feed ratio of the starting monomers and the amount of each individual isocyanate incorporated into isocyanurate. The polyurethane coatings prepared with HD...