1. Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G.

    Chemistry & Biology 22(12):1608 (2015) PMID 26670079 PMCID PMC4767166

    ERβ is regarded as a "tumor suppressor" in breast cancer due to its anti-proliferative effects. However, unlike ERα, ERβ has not been developed as a therapeutic target in breast cancer due to loss of ERβ in aggressive cancers. In a small-molecule library screen for ERβ stabilizers, we identified...
  2. Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer.

    Medicine (Baltimore) 94(47):e2081 (2015) PMID 26632716

    Somatic mutations, which are associated with a certain rate of response to targeted therapies, are ubiquitously found in human non-small cell lung cancer (NSCLC). However, it is largely unknown which group of patients may benefit from the respective treatments targeting different somatic mutatio...
  3. MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.

    Science advances 1(9):e1500463 (2015) PMID 26601288 PMCID PMC4646802

    The RNA polymerase II mediator complex subunit 12 (MED12) is frequently mutated in human cancers, and loss of MED12 has been shown to induce drug resistance through activation of transforming growth factor-β receptor (TGF-βR) signaling. We identified MED12 as a substrate for coactivator-associat...
  4. Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors.

    PLoS ONE 10(6):e0131955 (2015) PMID 26110850 PMCID PMC4482405

  5. Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.

    PLoS ONE 10(6):e0128143 (2015) PMID 26030442 PMCID PMC4451767

    Coactivator-associated arginine methyltransferase 1 (CARM1) is a coactivator for ERα and cancer-relevant transcription factors, and can methylate diverse cellular targets including histones. CARM1 is expressed in one of two alternative splice isoforms, full-length CARM1 (CARM1FL) and truncated C...
  6. CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.

    Cancer Cell 25(1):21 (2014) PMID 24434208 PMCID PMC4004525

    Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the functions of CARM1 in tumorigenesis, we knocked out CARM1 from several breast cancer cell lines using Zinc-Finger Nucl...
  7. Research resource: global identification of estrogen receptor β target genes in triple negative breast cancer cells.

    Molecular Endocrinology 27(10):1762 (2013) PMID 23979844 PMCID PMC3787129

    Breast cancers that are negative for estrogen receptor α (ERα), progesterone receptor, and human epidermal growth factor receptor 2 are known as triple-negative breast cancers (TNBC). TNBCs are associated with an overall poor prognosis because they lack expression of therapeutic targets like ERα...
  8. CARM1 automethylation is controlled at the level of alternative splicing.

    Nucleic Acids Research 41(14):6870 (2013) PMID 23723242 PMCID PMC3737532

    Co-activator-associated arginine methyltransferase 1 (CARM1) is subjected to multiple post-translational modifications. Our previous finding that automethylation of CARM1 is essential for regulation of transcription and pre-mRNA splicing prompted us to investigate how automethylation is regulate...
  9. Systematic analyses of the cytotoxic effects of compound 11a, a putative synthetic agonist of photoreceptor-specific nuclear receptor (PNR), in cancer cell lines.

    PLoS ONE 8(9):e75198 (2013) PMID 24066170 PMCID PMC3774666

    Photoreceptor cell-specific receptor (PNR/NR2E3) is an orphan nuclear receptor that plays a critical role in retinal development and photoreceptor maintenance. The disease-causing mutations in PNR have a pleiotropic effect resulting in varying retinal diseases. Recently, PNR has been implicated ...